Format
Sort by
Items per page

Send to

Choose Destination

Links from PubMed

Items: 1 to 20 of 99

1.

Binding modes and conformational changes of FK506-binding protein 51 induced by inhibitor bindings: insight into molecular mechanisms based on multiple simulation technologies.

Chen J, Yin B, Pang L, Wang W, Zhang JZH, Zhu T.

J Biomol Struct Dyn. 2019 Jun 14:1-15. doi: 10.1080/07391102.2019.1624616. [Epub ahead of print]

PMID:
31198099
2.

Decoding molecular mechanism of inhibitor bindings to CDK2 using molecular dynamics simulations and binding free energy calculations.

Chen J, Pang L, Wang W, Wang L, Zhang JZH, Zhu T.

J Biomol Struct Dyn. 2019 Mar 7:1-12. doi: 10.1080/07391102.2019.1591304. [Epub ahead of print]

PMID:
30843759
3.
4.

Differential conformational dynamics in the closely homologous FK506-binding domains of FKBP51 and FKBP52.

Mustafi SM, LeMaster DM, Hernández G.

Biochem J. 2014 Jul 1;461(1):115-23. doi: 10.1042/BJ20140232.

5.

Coupling of Conformational Transitions in the N-terminal Domain of the 51-kDa FK506-binding Protein (FKBP51) Near Its Site of Interaction with the Steroid Receptor Proteins.

LeMaster DM, Mustafi SM, Brecher M, Zhang J, Héroux A, Li H, Hernández G.

J Biol Chem. 2015 Jun 19;290(25):15746-57. doi: 10.1074/jbc.M115.650655. Epub 2015 May 7.

6.

Structural characterization of the PPIase domain of FKBP51, a cochaperone of human Hsp90.

Bracher A, Kozany C, Thost AK, Hausch F.

Acta Crystallogr D Biol Crystallogr. 2011 Jun;67(Pt 6):549-59. doi: 10.1107/S0907444911013862. Epub 2011 May 17.

PMID:
21636895
7.

Computational revelation of binding mechanisms of inhibitors to endocellular protein tyrosine phosphatase 1B using molecular dynamics simulations.

Yan F, Liu X, Zhang S, Su J, Zhang Q, Chen J.

J Biomol Struct Dyn. 2018 Nov;36(14):3636-3650. doi: 10.1080/07391102.2017.1394221. Epub 2017 Nov 6.

PMID:
29048995
8.

The helix 1-3 loop in the glucocorticoid receptor LBD is a regulatory element for FKBP cochaperones.

Cluning C, Ward BK, Rea SL, Arulpragasam A, Fuller PJ, Ratajczak T.

Mol Endocrinol. 2013 Jul;27(7):1020-35. doi: 10.1210/me.2012-1023. Epub 2013 May 17.

9.

Steroid up-regulation of FKBP51 and its role in hormone signaling.

Jääskeläinen T, Makkonen H, Palvimo JJ.

Curr Opin Pharmacol. 2011 Aug;11(4):326-31. doi: 10.1016/j.coph.2011.04.006. Epub 2011 Apr 29. Review.

PMID:
21531172
10.

A computational insight into binding modes of inhibitors XD29, XD35, and XD28 to bromodomain-containing protein 4 based on molecular dynamics simulations.

Su J, Liu X, Zhang S, Yan F, Zhang Q, Chen J.

J Biomol Struct Dyn. 2018 Apr;36(5):1212-1224. doi: 10.1080/07391102.2017.1317666. Epub 2017 May 3.

PMID:
28466681
11.

The prospect of FKBP51 as a drug target.

Schmidt MV, Paez-Pereda M, Holsboer F, Hausch F.

ChemMedChem. 2012 Aug;7(8):1351-9. doi: 10.1002/cmdc.201200137. Epub 2012 May 13.

PMID:
22581765
12.

Electrostatic interaction-mediated conformational changes of adipocyte fatty acid binding protein probed by molecular dynamics simulation.

Yan F, Liu X, Zhang S, Su J, Zhang Q, Chen J.

J Biomol Struct Dyn. 2019 Sep;37(14):3583-3595. doi: 10.1080/07391102.2018.1520648. Epub 2018 Nov 13.

PMID:
30193557
13.

InterAKTions with FKBPs--mutational and pharmacological exploration.

Fabian AK, März A, Neimanis S, Biondi RM, Kozany C, Hausch F.

PLoS One. 2013;8(2):e57508. doi: 10.1371/journal.pone.0057508. Epub 2013 Feb 28.

14.

Discovery and optimization of triazine derivatives as ROCK1 inhibitors: molecular docking, molecular dynamics simulations and free energy calculations.

Shen M, Zhou S, Li Y, Pan P, Zhang L, Hou T.

Mol Biosyst. 2013 Mar;9(3):361-74. doi: 10.1039/c2mb25408e. Epub 2013 Jan 23.

PMID:
23340525
15.

FK506-binding protein 51 regulates nuclear transport of the glucocorticoid receptor beta and glucocorticoid responsiveness.

Zhang X, Clark AF, Yorio T.

Invest Ophthalmol Vis Sci. 2008 Mar;49(3):1037-47. doi: 10.1167/iovs.07-1279.

16.

Combined x-ray crystallography and computational modeling approach to investigate the Hsp90 C-terminal peptide binding to FKBP51.

Kumar R, Moche M, Winblad B, Pavlov PF.

Sci Rep. 2017 Oct 27;7(1):14288. doi: 10.1038/s41598-017-14731-z.

17.

FKBP51 protects 661w cell culture from staurosporine-induced apoptosis.

Daudt DR, Yorio T.

Mol Vis. 2011;17:1172-81. Epub 2011 May 4.

18.

FKBP51 promotes assembly of the Hsp90 chaperone complex and regulates androgen receptor signaling in prostate cancer cells.

Ni L, Yang CS, Gioeli D, Frierson H, Toft DO, Paschal BM.

Mol Cell Biol. 2010 Mar;30(5):1243-53. doi: 10.1128/MCB.01891-08. Epub 2010 Jan 4.

19.

Calcium- and FK506-independent interaction between the immunophilin FKBP51 and calcineurin.

Li TK, Baksh S, Cristillo AD, Bierer BE.

J Cell Biochem. 2002;84(3):460-71.

PMID:
11813252
20.

The activity of the glucocorticoid receptor is regulated by SUMO conjugation to FKBP51.

Antunica-Noguerol M, Budziñski ML, Druker J, Gassen NC, Sokn MC, Senin S, Aprile-Garcia F, Holsboer F, Rein T, Liberman AC, Arzt E.

Cell Death Differ. 2016 Oct;23(10):1579-91. doi: 10.1038/cdd.2016.44. Epub 2016 May 13.

Supplemental Content

Support Center