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Items: 1 to 20 of 101

1.

Genetic toxicology in silico protocol.

Hasselgren C, Ahlberg E, Akahori Y, Amberg A, Anger LT, Atienzar F, Auerbach S, Beilke L, Bellion P, Benigni R, Bercu J, Booth ED, Bower D, Brigo A, Cammerer Z, Cronin MTD, Crooks I, Cross KP, Custer L, Dobo K, Doktorova T, Faulkner D, Ford KA, Fortin MC, Frericks M, Gad-McDonald SE, Gellatly N, Gerets H, Gervais V, Glowienke S, Van Gompel J, Harvey JS, Hillegass J, Honma M, Hsieh JH, Hsu CW, Barton-Maclaren TS, Johnson C, Jolly R, Jones D, Kemper R, Kenyon MO, Kruhlak NL, Kulkarni SA, Kümmerer K, Leavitt P, Masten S, Miller S, Moudgal C, Muster W, Paulino A, Lo Piparo E, Powley M, Quigley DP, Reddy MV, Richarz AN, Schilter B, Snyder RD, Stavitskaya L, Stidl R, Szabo DT, Teasdale A, Tice RR, Trejo-Martin A, Vuorinen A, Wall BA, Watts P, White AT, Wichard J, Witt KL, Woolley A, Woolley D, Zwickl C, Myatt GJ.

Regul Toxicol Pharmacol. 2019 Jun 11;107:104403. doi: 10.1016/j.yrtph.2019.104403. [Epub ahead of print]

2.

In silico toxicology protocols.

Myatt GJ, Ahlberg E, Akahori Y, Allen D, Amberg A, Anger LT, Aptula A, Auerbach S, Beilke L, Bellion P, Benigni R, Bercu J, Booth ED, Bower D, Brigo A, Burden N, Cammerer Z, Cronin MTD, Cross KP, Custer L, Dettwiler M, Dobo K, Ford KA, Fortin MC, Gad-McDonald SE, Gellatly N, Gervais V, Glover KP, Glowienke S, Van Gompel J, Gutsell S, Hardy B, Harvey JS, Hillegass J, Honma M, Hsieh JH, Hsu CW, Hughes K, Johnson C, Jolly R, Jones D, Kemper R, Kenyon MO, Kim MT, Kruhlak NL, Kulkarni SA, Kümmerer K, Leavitt P, Majer B, Masten S, Miller S, Moser J, Mumtaz M, Muster W, Neilson L, Oprea TI, Patlewicz G, Paulino A, Lo Piparo E, Powley M, Quigley DP, Reddy MV, Richarz AN, Ruiz P, Schilter B, Serafimova R, Simpson W, Stavitskaya L, Stidl R, Suarez-Rodriguez D, Szabo DT, Teasdale A, Trejo-Martin A, Valentin JP, Vuorinen A, Wall BA, Watts P, White AT, Wichard J, Witt KL, Woolley A, Woolley D, Zwickl C, Hasselgren C.

Regul Toxicol Pharmacol. 2018 Jul;96:1-17. doi: 10.1016/j.yrtph.2018.04.014. Epub 2018 Apr 17.

3.

The Consultancy Activity on In Silico Models for Genotoxic Prediction of Pharmaceutical Impurities.

Pavan M, Kovarich S, Bassan A, Broccardo L, Yang C, Fioravanzo E.

Methods Mol Biol. 2016;1425:511-29. doi: 10.1007/978-1-4939-3609-0_21.

PMID:
27311479
4.

Principles and procedures for implementation of ICH M7 recommended (Q)SAR analyses.

Amberg A, Beilke L, Bercu J, Bower D, Brigo A, Cross KP, Custer L, Dobo K, Dowdy E, Ford KA, Glowienke S, Van Gompel J, Harvey J, Hasselgren C, Honma M, Jolly R, Kemper R, Kenyon M, Kruhlak N, Leavitt P, Miller S, Muster W, Nicolette J, Plaper A, Powley M, Quigley DP, Reddy MV, Spirkl HP, Stavitskaya L, Teasdale A, Weiner S, Welch DS, White A, Wichard J, Myatt GJ.

Regul Toxicol Pharmacol. 2016 Jun;77:13-24. doi: 10.1016/j.yrtph.2016.02.004. Epub 2016 Feb 11.

5.

Use of in silico systems and expert knowledge for structure-based assessment of potentially mutagenic impurities.

Sutter A, Amberg A, Boyer S, Brigo A, Contrera JF, Custer LL, Dobo KL, Gervais V, Glowienke S, van Gompel J, Greene N, Muster W, Nicolette J, Reddy MV, Thybaud V, Vock E, White AT, Müller L.

Regul Toxicol Pharmacol. 2013 Oct;67(1):39-52. doi: 10.1016/j.yrtph.2013.05.001. Epub 2013 May 10.

PMID:
23669331
6.

In silico toxicology for the pharmaceutical sciences.

Valerio LG Jr.

Toxicol Appl Pharmacol. 2009 Dec 15;241(3):356-70. doi: 10.1016/j.taap.2009.08.022. Epub 2009 Aug 28. Review.

PMID:
19716836
7.

A practical application of two in silico systems for identification of potentially mutagenic impurities.

Greene N, Dobo KL, Kenyon MO, Cheung J, Munzner J, Sobol Z, Sluggett G, Zelesky T, Sutter A, Wichard J.

Regul Toxicol Pharmacol. 2015 Jul;72(2):335-49. doi: 10.1016/j.yrtph.2015.05.008. Epub 2015 May 15.

PMID:
25980641
8.

Establishing best practise in the application of expert review of mutagenicity under ICH M7.

Barber C, Amberg A, Custer L, Dobo KL, Glowienke S, Van Gompel J, Gutsell S, Harvey J, Honma M, Kenyon MO, Kruhlak N, Muster W, Stavitskaya L, Teasdale A, Vessey J, Wichard J.

Regul Toxicol Pharmacol. 2015 Oct;73(1):367-77. doi: 10.1016/j.yrtph.2015.07.018. Epub 2015 Aug 4.

PMID:
26248005
9.

(Q)SAR assessments of potentially mutagenic impurities: a regulatory perspective on the utility of expert knowledge and data submission.

Powley MW.

Regul Toxicol Pharmacol. 2015 Mar;71(2):295-300. doi: 10.1016/j.yrtph.2014.12.012. Epub 2014 Dec 26.

PMID:
25545315
10.

Unlocking the potential of in silico chemical safety assessment - A report on a cross-sector symposium on current opportunities and future challenges.

Cronin MTD, Madden JC, Yang C, Worth AP.

Comput Toxicol. 2019 May;10:38-43. doi: 10.1016/j.comtox.2018.12.006.

11.

Evidence-based toxicology: a comprehensive framework for causation.

Guzelian PS, Victoroff MS, Halmes NC, James RC, Guzelian CP.

Hum Exp Toxicol. 2005 Apr;24(4):161-201. Review.

PMID:
15957536
12.

In silico toxicology: computational methods for the prediction of chemical toxicity.

Raies AB, Bajic VB.

Wiley Interdiscip Rev Comput Mol Sci. 2016 Mar;6(2):147-172. Epub 2016 Jan 6. Review.

13.

The role of the European Chemicals Bureau in promoting the regulatory use of (Q)SAR methods.

Worth AP, Bassan A, De Bruijn J, Gallegos Saliner A, Netzeva T, Patlewicz G, Pavan M, Tsakovska I, Eisenreich S.

SAR QSAR Environ Res. 2007 Jan-Mar;18(1-2):111-25.

PMID:
17365963
14.

Current Knowledge on the Use of Computational Toxicology in Hazard Assessment of Metallic Engineered Nanomaterials.

Chen G, Peijnenburg W, Xiao Y, Vijver MG.

Int J Mol Sci. 2017 Jul 12;18(7). pii: E1504. doi: 10.3390/ijms18071504. Review.

15.

Computational toxicology as implemented by the U.S. EPA: providing high throughput decision support tools for screening and assessing chemical exposure, hazard and risk.

Kavlock R, Dix D.

J Toxicol Environ Health B Crit Rev. 2010 Feb;13(2-4):197-217. doi: 10.1080/10937404.2010.483935.

PMID:
20574897
16.

Principles and procedures for handling out-of-domain and indeterminate results as part of ICH M7 recommended (Q)SAR analyses.

Amberg A, Andaya RV, Anger LT, Barber C, Beilke L, Bercu J, Bower D, Brigo A, Cammerer Z, Cross KP, Custer L, Dobo K, Gerets H, Gervais V, Glowienke S, Gomez S, Van Gompel J, Harvey J, Hasselgren C, Honma M, Johnson C, Jolly R, Kemper R, Kenyon M, Kruhlak N, Leavitt P, Miller S, Muster W, Naven R, Nicolette J, Parenty A, Powley M, Quigley DP, Reddy MV, Sasaki JC, Stavitskaya L, Teasdale A, Trejo-Martin A, Weiner S, Welch DS, White A, Wichard J, Woolley D, Myatt GJ.

Regul Toxicol Pharmacol. 2019 Mar;102:53-64. doi: 10.1016/j.yrtph.2018.12.007. Epub 2018 Dec 15.

17.

Safety and nutritional assessment of GM plants and derived food and feed: the role of animal feeding trials.

EFSA GMO Panel Working Group on Animal Feeding Trials.

Food Chem Toxicol. 2008 Mar;46 Suppl 1:S2-70. doi: 10.1016/j.fct.2008.02.008. Epub 2008 Feb 13. Review.

PMID:
18328408
18.

Carbamates and ICH M7 classification: Making use of expert knowledge.

Hemingway R, Fowkes A, Williams RV.

Regul Toxicol Pharmacol. 2017 Jun;86:392-401. doi: 10.1016/j.yrtph.2017.03.025. Epub 2017 Apr 4.

PMID:
28385577
19.

The challenges involved in modeling toxicity data in silico: a review.

Gleeson MP, Modi S, Bender A, Robinson RL, Kirchmair J, Promkatkaew M, Hannongbua S, Glen RC.

Curr Pharm Des. 2012;18(9):1266-91. Review.

PMID:
22316153
20.

Mutagenicity assessment strategy for pharmaceutical intermediates to aid limit setting for occupational exposure.

Araya S, Lovsin-Barle E, Glowienke S.

Regul Toxicol Pharmacol. 2015 Nov;73(2):515-20. doi: 10.1016/j.yrtph.2015.10.001. Epub 2015 Oct 8.

PMID:
26454093

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