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Frankincense essential oil suppresses melanoma cancer through down regulation of Bcl-2/Bax cascade signaling and ameliorates heptotoxicity via phase I and II drug metabolizing enzymes.

Hakkim FL, Bakshi HA, Khan S, Nasef M, Farzand R, Sam S, Rashan L, Al-Baloshi MS, Abdo Hasson SSA, Jabri AA, McCarron PA, Tambuwala MM.

Oncotarget. 2019 May 28;10(37):3472-3490. doi: 10.18632/oncotarget.26930. eCollection 2019 May 28.


Capsaicin induced apoptosis of B16-F10 melanoma cells through down-regulation of Bcl-2.

Jun HS, Park T, Lee CK, Kang MK, Park MS, Kang HI, Surh YJ, Kim OH.

Food Chem Toxicol. 2007 May;45(5):708-15. Epub 2006 Oct 27.


Frankincense essential oil prepared from hydrodistillation of Boswellia sacra gum resins induces human pancreatic cancer cell death in cultures and in a xenograft murine model.

Ni X, Suhail MM, Yang Q, Cao A, Fung KM, Postier RG, Woolley C, Young G, Zhang J, Lin HK.

BMC Complement Altern Med. 2012 Dec 13;12:253. doi: 10.1186/1472-6882-12-253.


NTP Toxicology and Carcinogenesis Studies of Coumarin (CAS No. 91-64-5) in F344/N Rats and B6C3F1 Mice (Gavage Studies).

National Toxicology Program .

Natl Toxicol Program Tech Rep Ser. 1993 Sep;422:1-340.


Ethanol extract of Ilex hainanensis Merr. exhibits anti-melanoma activity by induction of G1/S cell-cycle arrest and apoptosis.

Zhang YQ, Yang H, Sun WD, Wang J, Zhang BY, Shen YJ, Yin MQ, Liu YX, Liu C, Sun Y.

Chin J Integr Med. 2018 Jan;24(1):47-55. doi: 10.1007/s11655-017-2544-8. Epub 2017 Jul 25.


Protective Effects of Essential Oils as Natural Antioxidants against Hepatotoxicity Induced by Cyclophosphamide in Mice.

Sheweita SA, El-Hosseiny LS, Nashashibi MA.

PLoS One. 2016 Nov 1;11(11):e0165667. doi: 10.1371/journal.pone.0165667. eCollection 2016.


Phenothiazines induce apoptosis in a B16 mouse melanoma cell line and attenuate in vivo melanoma tumor growth.

Gil-Ad I, Shtaif B, Levkovitz Y, Nordenberg J, Taler M, Korov I, Weizman A.

Oncol Rep. 2006 Jan;15(1):107-12.


Taurolidine induces apoptosis of murine melanoma cells in vitro and in vivo by modulation of the Bcl-2 family proteins.

Sun BS, Wang JH, Liu LL, Gong SL, Redmond HP.

J Surg Oncol. 2007 Sep 1;96(3):241-8.


Thymoquinone Enhances the Effect of Gamma Knife in B16-F10 Melanoma Through Inhibition of Phosphorylated STAT3.

Hatiboglu MA, Kocyigit A, Guler EM, Akdur K, Khan I, Nalli A, Karatas E, Tuzgen S.

World Neurosurg. 2019 May 2. pii: S1878-8750(19)31201-X. doi: 10.1016/j.wneu.2019.04.205. [Epub ahead of print]


Flavonoids inhibit cell growth and induce apoptosis in B16 melanoma 4A5 cells.

Iwashita K, Kobori M, Yamaki K, Tsushida T.

Biosci Biotechnol Biochem. 2000 Sep;64(9):1813-20.


Matrine induces apoptosis in multiple colorectal cancer cell lines in vitro and inhibits tumour growth with minimum side effects in vivo via Bcl-2 and caspase-3.

Gu YY, Chen MH, May BH, Liao XZ, Liu JH, Tao LT, Man-Yuen Sze D, Zhang AL, Mo SL.

Phytomedicine. 2018 Dec 1;51:214-225. doi: 10.1016/j.phymed.2018.10.004. Epub 2018 Oct 6.


Thymoquinone Induces Apoptosis in B16-F10 Melanoma Cell Through Inhibition of p-STAT3 and Inhibits Tumor Growth in a Murine Intracerebral Melanoma Model.

Hatiboglu MA, Kocyigit A, Guler EM, Akdur K, Nalli A, Karatas E, Tuzgen S.

World Neurosurg. 2018 Jun;114:e182-e190. doi: 10.1016/j.wneu.2018.02.136. Epub 2018 Mar 3.


Nitric oxide mediates natural polyphenol-induced Bcl-2 down-regulation and activation of cell death in metastatic B16 melanoma.

Ferrer P, Asensi M, Priego S, Benlloch M, Mena S, Ortega A, Obrador E, Esteve JM, Estrela JM.

J Biol Chem. 2007 Feb 2;282(5):2880-90. Epub 2006 Nov 29.


Preparation of coffee oil-algae oil-based nanoemulsions and the study of their inhibition effect on UVA-induced skin damage in mice and melanoma cell growth.

Yang CC, Hung CF, Chen BH.

Int J Nanomedicine. 2017 Sep 5;12:6559-6580. doi: 10.2147/IJN.S144705. eCollection 2017.


Antitumor effect of iRGD-modified liposomes containing conjugated linoleic acid-paclitaxel (CLA-PTX) on B16-F10 melanoma.

Du R, Zhong T, Zhang WQ, Song P, Song WD, Zhao Y, Wang C, Tang YQ, Zhang X, Zhang Q.

Int J Nanomedicine. 2014 Jun 24;9:3091-105. doi: 10.2147/IJN.S65664. eCollection 2014.


Bcl-2 and glutathione depletion sensitizes B16 melanoma to combination therapy and eliminates metastatic disease.

Mena S, Benlloch M, Ortega A, Carretero J, Obrador E, Asensi M, Petschen I, Brown BD, Estrela JM.

Clin Cancer Res. 2007 May 1;13(9):2658-66.

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