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Items: 1 to 20 of 98

1.

Both GSK-3β/CRMP2 and CDK5/CRMP2 pathways participate in the protection of dexmedetomidine against propofol-induced learning and memory impairment in neonatal rats.

Li J, Guo M, Liu Y, Wu G, Miao L, Zhang J, Zuo Z, Li Y.

Toxicol Sci. 2019 Jun 10. pii: kfz135. doi: 10.1093/toxsci/kfz135. [Epub ahead of print]

PMID:
31187143
2.

Dexmedetomidine attenuates repeated propofol exposure-induced hippocampal apoptosis, PI3K/Akt/Gsk-3β signaling disruption, and juvenile cognitive deficits in neonatal rats.

Wang Y, Wu C, Han B, Xu F, Mao M, Guo X, Wang J.

Mol Med Rep. 2016 Jul;14(1):769-75. doi: 10.3892/mmr.2016.5321. Epub 2016 May 23.

3.

(S)-Lacosamide Binding to Collapsin Response Mediator Protein 2 (CRMP2) Regulates CaV2.2 Activity by Subverting Its Phosphorylation by Cdk5.

Moutal A, François-Moutal L, Perez-Miller S, Cottier K, Chew LA, Yeon SK, Dai J, Park KD, Khanna M, Khanna R.

Mol Neurobiol. 2016 Apr;53(3):1959-1976. doi: 10.1007/s12035-015-9141-2. Epub 2015 Apr 7.

PMID:
25846820
4.

Perinatal exposure to lead (Pb) promotes Tau phosphorylation in the rat brain in a GSK-3β and CDK5 dependent manner: Relevance to neurological disorders.

Gąssowska M, Baranowska-Bosiacka I, Moczydłowska J, Tarnowski M, Pilutin A, Gutowska I, Strużyńska L, Chlubek D, Adamczyk A.

Toxicology. 2016 Mar 10;347-349:17-28. doi: 10.1016/j.tox.2016.03.002. Epub 2016 Mar 21.

PMID:
27012722
5.

Both JNK and P38 MAPK pathways participate in the protection by dexmedetomidine against isoflurane-induced neuroapoptosis in the hippocampus of neonatal rats.

Liao Z, Cao D, Han X, Liu C, Peng J, Zuo Z, Wang F, Li Y.

Brain Res Bull. 2014 Aug;107:69-78. doi: 10.1016/j.brainresbull.2014.07.001. Epub 2014 Jul 12.

PMID:
25026397
6.

Cyclin-dependent kinase 5/Collapsin response mediator protein 2 pathway may mediate sevoflurane-induced dendritic development abnormalities in rat cortical neurons.

Liu Y, Lin D, Liu C, Zhao Y, Shen Z, Zhang K, Cao M, Li Y.

Neurosci Lett. 2017 Jun 9;651:21-29. doi: 10.1016/j.neulet.2017.04.040. Epub 2017 Apr 24.

PMID:
28445771
7.

Dexmedetomidine attenuates propofol-induce neuroapoptosis partly via the activation of the PI3k/Akt/GSK3β pathway in the hippocampus of neonatal rats.

Lv J, Wei Y, Chen Y, Zhang X, Gong Z, Jiang Y, Gong Q, Zhou L, Wang H, Xie Y.

Environ Toxicol Pharmacol. 2017 Jun;52:121-128. doi: 10.1016/j.etap.2017.03.017. Epub 2017 Mar 28.

PMID:
28411582
8.

Influence of sevoflurane exposure on mitogen-activated protein kinases and Akt/GSK-3β/CRMP-2 signaling pathways in the developing rat brain.

Liu Y, Liu C, Zeng M, Han X, Zhang K, Fu Y, Li J, Li Y.

Exp Ther Med. 2018 Feb;15(2):2066-2073. doi: 10.3892/etm.2017.5651. Epub 2017 Dec 18.

9.

Roscovitine, a CDK5 Inhibitor, Alleviates Sevoflurane-Induced Cognitive Dysfunction via Regulation Tau/GSK3β and ERK/PPARγ/CREB Signaling.

Liu J, Yang J, Xu Y, Guo G, Cai L, Wu H, Zhao Y, Zhang X.

Cell Physiol Biochem. 2017;44(2):423-435. doi: 10.1159/000485008. Epub 2017 Nov 15.

10.

Amyloid-β₂₅₋₃₅ induces impairment of cognitive function and long-term potentiation through phosphorylation of collapsin response mediator protein 2.

Isono T, Yamashita N, Obara M, Araki T, Nakamura F, Kamiya Y, Alkam T, Nitta A, Nabeshima T, Mikoshiba K, Ohshima T, Goshima Y.

Neurosci Res. 2013 Nov;77(3):180-5. doi: 10.1016/j.neures.2013.08.005. Epub 2013 Aug 29.

PMID:
23994236
11.

Orengedokuto and san'oshashinto improve memory deficits by inhibiting aging-dependent activation of glycogen synthase kinase-3β.

Fujiwara H, Yoshida J, Dibwe DF, Awale S, Hoshino H, Kohama H, Arai H, Kudo Y, Matsumoto K.

J Tradit Complement Med. 2018 Dec 27;9(4):328-335. doi: 10.1016/j.jtcme.2018.12.001. eCollection 2019 Oct.

12.

Dexmedetomidine Protects Neural Stem Cells from Ketamine-Induced Injury.

Lu P, Lei S, Li W, Lu Y, Zheng J, Wang N, Xia Y, Lu H, Chen X, Liu Y, Zhang PB.

Cell Physiol Biochem. 2018;47(4):1377-1388. doi: 10.1159/000490823. Epub 2018 Jun 19.

13.

Role of glycogen synthase kinase-3β in ketamine-induced developmental neuroapoptosis in rats.

Liu JR, Baek C, Han XH, Shoureshi P, Soriano SG.

Br J Anaesth. 2013 Jun;110 Suppl 1:i3-9. doi: 10.1093/bja/aet057. Epub 2013 Mar 26.

14.

N-methyl-D-aspartate receptors mediate epilepsy-induced axonal impairment and tau phosphorylation via activating glycogen synthase kinase-3β and cyclin-dependent kinase 5.

Liu X, Ou S, Yin M, Xu T, Wang T, Liu Y, Ding X, Yu X, Yuan J, Huang H, Zhang X, Tan X, Chen L, Chen Y.

Discov Med. 2017 Apr;23(127):221-234.

15.

Dexmedetomidine reduces isoflurane-induced neuroapoptosis partly by preserving PI3K/Akt pathway in the hippocampus of neonatal rats.

Li Y, Zeng M, Chen W, Liu C, Wang F, Han X, Zuo Z, Peng S.

PLoS One. 2014 Apr 17;9(4):e93639. doi: 10.1371/journal.pone.0093639. eCollection 2014.

16.

Both PI3K/Akt and ERK1/2 pathways participate in the protection by dexmedetomidine against transient focal cerebral ischemia/reperfusion injury in rats.

Zhu YM, Wang CC, Chen L, Qian LB, Ma LL, Yu J, Zhu MH, Wen CY, Yu LN, Yan M.

Brain Res. 2013 Feb 4;1494:1-8. doi: 10.1016/j.brainres.2012.11.047. Epub 2012 Dec 5.

PMID:
23219579
17.

Inhibition of aberrant cyclin-dependent kinase 5 activity attenuates isoflurane neurotoxicity in the developing brain.

Wang WY, Luo Y, Jia LJ, Hu SF, Lou XK, Shen SL, Lu H, Zhang HH, Yang R, Wang H, Ma ZW, Xue QS, Yu BW.

Neuropharmacology. 2014 Feb;77:90-9. doi: 10.1016/j.neuropharm.2013.09.006. Epub 2013 Sep 18.

PMID:
24055498
18.

PKA-CREB-BDNF signaling pathway mediates propofol-induced long-term learning and memory impairment in hippocampus of rats.

Zhong Y, Chen J, Li L, Qin Y, Wei Y, Pan S, Jiang Y, Chen J, Xie Y.

Brain Res. 2018 Jul 15;1691:64-74. doi: 10.1016/j.brainres.2018.04.022. Epub 2018 Apr 21.

PMID:
29684336
19.

Inhibition of glycogen synthase kinase 3 beta attenuates neurocognitive dysfunction resulting from cranial irradiation.

Thotala DK, Hallahan DE, Yazlovitskaya EM.

Cancer Res. 2008 Jul 15;68(14):5859-68. doi: 10.1158/0008-5472.CAN-07-6327. Erratum in: Cancer Res. 2008 Oct 1;68(19):8189.

20.

Mori Fructus improves cognitive and neuronal dysfunction induced by beta-amyloid toxicity through the GSK-3β pathway in vitro and in vivo.

Kim HG, Park G, Lim S, Park H, Choi JG, Jeong HU, Kang MS, Lee MK, Oh MS.

J Ethnopharmacol. 2015 Aug 2;171:196-204. doi: 10.1016/j.jep.2015.05.054. Epub 2015 Jun 9.

PMID:
26068423

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