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CYP450s-Activity Relations of Celastrol to Interact with Triptolide Reveal the Reasons of Hepatotoxicity of Tripterygium wilfordii.

Jin C, Wu Z, Wang L, Kanai Y, He X.

Molecules. 2019 Jun 8;24(11). pii: E2162. doi: 10.3390/molecules24112162.


A Mechanistic Overview of Triptolide and Celastrol, Natural Products from Tripterygium wilfordii Hook F.

Chen SR, Dai Y, Zhao J, Lin L, Wang Y, Wang Y.

Front Pharmacol. 2018 Feb 14;9:104. doi: 10.3389/fphar.2018.00104. eCollection 2018. Review.


Overexpression and RNAi-mediated downregulation of TwIDI regulates triptolide and celastrol accumulation in Tripterygium wilfordii.

Wang J, Zhao Y, Zhang Y, Su P, Hu T, Lu Y, Zhang R, Zhou J, Ma B, Gao W, Huang L.

Gene. 2018 Dec 30;679:195-201. doi: 10.1016/j.gene.2018.08.072. Epub 2018 Sep 5.


Triptolide Induces hepatotoxicity via inhibition of CYP450s in Rat liver microsomes.

Lu Y, Xie T, Zhang Y, Zhou F, Ruan J, Zhu W, Zhu H, Feng Z, Zhou X.

BMC Complement Altern Med. 2017 Jan 5;17(1):15. doi: 10.1186/s12906-016-1504-3.


Synergistic anticancer effects of triptolide and celastrol, two main compounds from thunder god vine.

Jiang QW, Cheng KJ, Mei XL, Qiu JG, Zhang WJ, Xue YQ, Qin WM, Yang Y, Zheng DW, Chen Y, Wei MN, Zhang X, Lv M, Chen MW, Wei X, Shi Z.

Oncotarget. 2015 Oct 20;6(32):32790-804. doi: 10.18632/oncotarget.5411.


Comparative analysis of four terpenoids in root and cortex of Tripterygium wilfordii Radix by different drying methods.

Wang T, Shen F, Su S, Bai Y, Guo S, Yan H, Ji T, Wang Y, Qian D, Duan JA.

BMC Complement Altern Med. 2016 Nov 23;16(1):476.


Identification and functional characterization of diterpene synthases for triptolide biosynthesis from Tripterygium wilfordii.

Su P, Guan H, Zhao Y, Tong Y, Xu M, Zhang Y, Hu T, Yang J, Cheng Q, Gao L, Liu Y, Zhou J, Peters RJ, Huang L, Gao W.

Plant J. 2018 Jan;93(1):50-65. doi: 10.1111/tpj.13756. Epub 2017 Dec 2.


Role of CYP3A in regulating hepatic clearance and hepatotoxicity of triptolide in rat liver microsomes and sandwich-cultured hepatocytes.

Shen G, Zhuang X, Xiao W, Kong L, Tan Y, Li H.

Food Chem Toxicol. 2014 Sep;71:90-6. doi: 10.1016/j.fct.2014.05.020. Epub 2014 Jun 6.


Further Study of Influence of Panax notoginseng on Intestinal Absorption Characteristics of Triptolide and Tripterine in Rats with Tripterygium wilfordii.

Li Y, Zhang B, Liu M, Zhang X, Shi D, Guo L, Duan J, Zhou X, Zhu H, Zhang Q.

Pharmacogn Mag. 2018 Jan-Mar;14(53):95-102. doi: 10.4103/pm.pm_67_17. Epub 2018 Feb 20.


Drp1-associated mitochondrial dysfunction and mitochondrial autophagy: a novel mechanism in triptolide-induced hepatotoxicity.

Hasnat M, Yuan Z, Naveed M, Khan A, Raza F, Xu D, Ullah A, Sun L, Zhang L, Jiang Z.

Cell Biol Toxicol. 2019 Jun;35(3):267-280. doi: 10.1007/s10565-018-9447-8. Epub 2018 Dec 13.


Triptolide: progress on research in pharmacodynamics and toxicology.

Li XJ, Jiang ZZ, Zhang LY.

J Ethnopharmacol. 2014 Aug 8;155(1):67-79. doi: 10.1016/j.jep.2014.06.006. Epub 2014 Jun 13. Review.


[Preliminary study on effective components of Tripterygium wilfordii for liver toxicity based on spectrum-effect correlation analysis].

Zhao XM, Pu SB, Zhao QG, Gong M, Wang JB, Ma ZJ, Xiao XH, Zhao KJ.

Zhongguo Zhong Yao Za Zhi. 2016 Aug;41(15):2915-2921. doi: 10.4268/cjcmm20161527. Chinese.


[Several monomes from Tripterygium wilfordii inhibit proliferation of glioma cells in vitro].

Zhou YX, Huang YL, Xu QN, Ye M, Sun CF, Zhou D.

Ai Zheng. 2002 Oct;21(10):1106-8. Chinese.


Triptolide inhibits the proliferation of prostate cancer cells and down-regulates SUMO-specific protease 1 expression.

Huang W, He T, Chai C, Yang Y, Zheng Y, Zhou P, Qiao X, Zhang B, Liu Z, Wang J, Shi C, Lei L, Gao K, Li H, Zhong S, Yao L, Huang ME, Lei M.

PLoS One. 2012;7(5):e37693. doi: 10.1371/journal.pone.0037693. Epub 2012 May 30.


Knockout of hepatic P450 reductase aggravates triptolide-induced toxicity.

Xue X, Gong L, Qi X, Wu Y, Xing G, Yao J, Luan Y, Xiao Y, Li Y, Wu X, Chen M, Gu J, Ren J.

Toxicol Lett. 2011 Aug 10;205(1):47-54. doi: 10.1016/j.toxlet.2011.05.003. Epub 2011 May 10.


Activation of Nrf2 protects against triptolide-induced hepatotoxicity.

Li J, Shen F, Guan C, Wang W, Sun X, Fu X, Huang M, Jin J, Huang Z.

PLoS One. 2014 Jul 2;9(7):e100685. doi: 10.1371/journal.pone.0100685. eCollection 2014.


Metabolic alterations in triptolide-induced acute hepatotoxicity.

Zhao J, Xie C, Mu X, Krausz KW, Patel DP, Shi X, Gao X, Wang Q, Gonzalez FJ.

Biomed Chromatogr. 2018 Oct;32(10):e4299. doi: 10.1002/bmc.4299. Epub 2018 Jul 4.


Tripterygium wilfordii bioactive compounds as anticancer and anti-inflammatory agents.

Wong KF, Yuan Y, Luk JM.

Clin Exp Pharmacol Physiol. 2012 Mar;39(3):311-20. doi: 10.1111/j.1440-1681.2011.05586.x. Review.


Triptolide Induces Apoptosis Through Fas Death and Mitochondrial Pathways in HepaRG Cell Line.

You L, Dong X, Ni B, Fu J, Yang C, Yin X, Leng X, Ni J.

Front Pharmacol. 2018 Jul 26;9:813. doi: 10.3389/fphar.2018.00813. eCollection 2018.

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