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Eupatilin Inhibits Renal Cancer Growth by Downregulating MicroRNA-21 through the Activation of YAP1.

Zhong W, Wu Z, Chen N, Zhong K, Lin Y, Jiang H, Wan P, Lu S, Yang L, Liu S.

Biomed Res Int. 2019 Apr 24;2019:5016483. doi: 10.1155/2019/5016483. eCollection 2019.


MicroRNA-212 inhibits the proliferation, migration and invasion of renal cell carcinoma by targeting X-linked inhibitor of apoptosis protein (XIAP).

Gu C, Wang Z, Jin Z, Li G, Kou Y, Jia Z, Yang J, Tian F.

Oncotarget. 2017 Sep 8;8(54):92119-92133. doi: 10.18632/oncotarget.20786. eCollection 2017 Nov 3.


Eupatilin induces human renal cancer cell apoptosis via ROS-mediated MAPK and PI3K/AKT signaling pathways.

Zhong WF, Wang XH, Pan B, Li F, Kuang L, Su ZX.

Oncol Lett. 2016 Oct;12(4):2894-2899. Epub 2016 Aug 10.


Protective Effect of Artemisia asiatica Extract and Its Active Compound Eupatilin against Cisplatin-Induced Renal Damage.

Park JY, Lee D, Jang HJ, Jang DS, Kwon HC, Kim KH, Kim SN, Hwang GS, Kang KS, Eom DW.

Evid Based Complement Alternat Med. 2015;2015:483980. doi: 10.1155/2015/483980. Epub 2015 Oct 11.


Eupatilin inhibits H(2)O(2)-induced apoptotic cell death through inhibition of mitogen-activated protein kinases and nuclear factor-kappaB.

Lee S, Lee M, Kim SH.

Food Chem Toxicol. 2008 Aug;46(8):2865-70. doi: 10.1016/j.fct.2008.05.026. Epub 2008 Jun 3.


Anticancer effect of eupatilin on glioma cells through inhibition of the Notch-1 signaling pathway.

Wang Y, Hou H, Li M, Yang Y, Sun L.

Mol Med Rep. 2016 Feb;13(2):1141-6. doi: 10.3892/mmr.2015.4671. Epub 2015 Dec 10.


Eupatilin inhibits glioma proliferation, migration, and invasion by arresting cell cycle at G1/S phase and disrupting the cytoskeletal structure.

Fei X, Wang J, Chen C, Ding B, Fu X, Chen W, Wang C, Xu R.

Cancer Manag Res. 2019 May 24;11:4781-4796. doi: 10.2147/CMAR.S207257. eCollection 2019.


Inhibitory effects of eupatilin on tumor invasion of human gastric cancer MKN-1 cells.

Park BB, Yoon Js, Kim Es, Choi J, Won Yw, Choi Jh, Lee YY.

Tumour Biol. 2013 Apr;34(2):875-85. doi: 10.1007/s13277-012-0621-y. Epub 2013 Jan 8.


Tumor suppressor miR-211-5p is associated with cellular migration, proliferation and apoptosis in renal cell carcinoma.

Quan J, Pan X, He T, Lin C, Lai Y, Chen P, Zhang Z, Yang S, Wang T, Lai Y.

Exp Ther Med. 2018 Apr;15(4):4019-4028. doi: 10.3892/etm.2018.5908. Epub 2018 Feb 28.


miR-137 inhibits renal cell carcinoma growth in vitro and in vivo.

Zhang H, Li H.

Oncol Lett. 2016 Jul;12(1):715-720. Epub 2016 May 24.


MicroRNA-99a induces G1-phase cell cycle arrest and suppresses tumorigenicity in renal cell carcinoma.

Cui L, Zhou H, Zhao H, Zhou Y, Xu R, Xu X, Zheng L, Xue Z, Xia W, Zhang B, Ding T, Cao Y, Tian Z, Shi Q, He X.

BMC Cancer. 2012 Nov 23;12:546. doi: 10.1186/1471-2407-12-546.


Eupatilin, a major flavonoid of Artemisia, attenuates aortic smooth muscle cell proliferation and migration by inhibiting PI3K, MKK3/6, and MKK4 activities.

Son JE, Lee E, Seo SG, Lee J, Kim JE, Kim J, Lee KW, Lee HJ.

Planta Med. 2013 Aug;79(12):1009-16. doi: 10.1055/s-0033-1350621. Epub 2013 Jul 22.


MicroRNA-22 functions as a tumor suppressor by targeting SIRT1 in renal cell carcinoma.

Zhang S, Zhang D, Yi C, Wang Y, Wang H, Wang J.

Oncol Rep. 2016 Jan;35(1):559-67. doi: 10.3892/or.2015.4333. Epub 2015 Oct 16.


Eupatilin, a pharmacologically active flavone derived from Artemisia plants, induces apoptosis in human gastric cancer (AGS) cells.

Kim MJ, Kim DH, Na HK, Oh TY, Shin CY, Surh Ph D Professor YJ.

J Environ Pathol Toxicol Oncol. 2005;24(4):261-9.


MiR-216a exerts tumor-suppressing functions in renal cell carcinoma by targeting TLR4.

Wang W, Zhao E, Yu Y, Geng B, Zhang W, Li X.

Am J Cancer Res. 2018 Mar 1;8(3):476-488. eCollection 2018.


Downregulation of microRNA-15a suppresses the proliferation and invasion of renal cell carcinoma via direct targeting of eIF4E.

Li G, Chong T, Xiang X, Yang J, Li H.

Oncol Rep. 2017 Oct;38(4):1995-2002. doi: 10.3892/or.2017.5901. Epub 2017 Aug 11.


MicroRNA-338-3p targets SOX4 and inhibits cell proliferation and invasion of renal cell carcinoma.

Tong Z, Meng X, Wang J, Wang L.

Exp Ther Med. 2017 Nov;14(5):5200-5206. doi: 10.3892/etm.2017.5169. Epub 2017 Sep 21.


miR-488 inhibits cell growth and metastasis in renal cell carcinoma by targeting HMGN5.

Wei X, Yu L, Kong X.

Onco Targets Ther. 2018 Apr 18;11:2205-2216. doi: 10.2147/OTT.S156361. eCollection 2018.

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