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Items: 1 to 20 of 101

1.

Synthesis and in vivo evaluation of [18F]UCB-J for PET imaging of synaptic vesicle glycoprotein 2A (SV2A).

Li S, Cai Z, Zhang W, Holden D, Lin SF, Finnema SJ, Shirali A, Ropchan J, Carre S, Mercier J, Carson RE, Nabulsi N, Huang Y.

Eur J Nucl Med Mol Imaging. 2019 Aug;46(9):1952-1965. doi: 10.1007/s00259-019-04357-w. Epub 2019 Jun 7.

PMID:
31175396
2.

Synthesis and in Vivo Evaluation of a Novel PET Radiotracer for Imaging of Synaptic Vesicle Glycoprotein 2A (SV2A) in Nonhuman Primates.

Li S, Cai Z, Wu X, Holden D, Pracitto R, Kapinos M, Gao H, Labaree D, Nabulsi N, Carson RE, Huang Y.

ACS Chem Neurosci. 2019 Mar 20;10(3):1544-1554. doi: 10.1021/acschemneuro.8b00526. Epub 2018 Nov 16.

PMID:
30396272
3.

Synthesis and Preclinical Evaluation of 11C-UCB-J as a PET Tracer for Imaging the Synaptic Vesicle Glycoprotein 2A in the Brain.

Nabulsi NB, Mercier J, Holden D, Carré S, Najafzadeh S, Vandergeten MC, Lin SF, Deo A, Price N, Wood M, Lara-Jaime T, Montel F, Laruelle M, Carson RE, Hannestad J, Huang Y.

J Nucl Med. 2016 May;57(5):777-84. doi: 10.2967/jnumed.115.168179. Epub 2016 Feb 4.

4.

Development and In Vivo Preclinical Imaging of Fluorine-18-Labeled Synaptic Vesicle Protein 2A (SV2A) PET Tracers.

Constantinescu CC, Tresse C, Zheng M, Gouasmat A, Carroll VM, Mistico L, Alagille D, Sandiego CM, Papin C, Marek K, Seibyl JP, Tamagnan GD, Barret O.

Mol Imaging Biol. 2019 Jun;21(3):509-518. doi: 10.1007/s11307-018-1260-5.

PMID:
30084043
5.

Novel 18F-Labeled κ-Opioid Receptor Antagonist as PET Radiotracer: Synthesis and In Vivo Evaluation of 18F-LY2459989 in Nonhuman Primates.

Li S, Cai Z, Zheng MQ, Holden D, Naganawa M, Lin SF, Ropchan J, Labaree D, Kapinos M, Lara-Jaime T, Navarro A, Huang Y.

J Nucl Med. 2018 Jan;59(1):140-146. doi: 10.2967/jnumed.117.195586. Epub 2017 Jul 26.

6.

Evaluation of 18F-UCB-H as a novel PET tracer for synaptic vesicle protein 2A in the brain.

Warnock GI, Aerts J, Bahri MA, Bretin F, Lemaire C, Giacomelli F, Mievis F, Mestdagh N, Buchanan T, Valade A, Mercier J, Wood M, Gillard M, Seret A, Luxen A, Salmon E, Plenevaux A.

J Nucl Med. 2014 Aug;55(8):1336-41. doi: 10.2967/jnumed.113.136143. Epub 2014 Jun 16.

7.

Measuring brain synaptic vesicle protein 2A with positron emission tomography and [18F]UCB-H.

Bahri MA, Plenevaux A, Aerts J, Bastin C, Becker G, Mercier J, Valade A, Buchanan T, Mestdagh N, Ledoux D, Seret A, Luxen A, Salmon E.

Alzheimers Dement (N Y). 2017 Aug 30;3(4):481-486. doi: 10.1016/j.trci.2017.08.004. eCollection 2017 Nov.

8.
9.

Pharmacokinetic Characterization of [18F]UCB-H PET Radiopharmaceutical in the Rat Brain.

Becker G, Warnier C, Serrano ME, Bahri MA, Mercier J, Lemaire C, Salmon E, Luxen A, Plenevaux A.

Mol Pharm. 2017 Aug 7;14(8):2719-2725. doi: 10.1021/acs.molpharmaceut.7b00235. Epub 2017 Jul 13.

PMID:
28651055
10.

Assessing Synaptic Density in Alzheimer Disease With Synaptic Vesicle Glycoprotein 2A Positron Emission Tomographic Imaging.

Chen MK, Mecca AP, Naganawa M, Finnema SJ, Toyonaga T, Lin SF, Najafzadeh S, Ropchan J, Lu Y, McDonald JW, Michalak HR, Nabulsi NB, Arnsten AFT, Huang Y, Carson RE, van Dyck CH.

JAMA Neurol. 2018 Oct 1;75(10):1215-1224. doi: 10.1001/jamaneurol.2018.1836.

11.

In vivo synaptic density imaging with 11C-UCB-J detects treatment effects of saracatinib (AZD0530) in a mouse model of Alzheimer's disease.

Toyonaga T, Smith LM, Finnema SJ, Gallezot JD, Naganawa M, Bini J, Mulnix T, Cai Z, Ropchan J, Huang Y, Strittmatter SM, Carson RE.

J Nucl Med. 2019 May 17. pii: jnumed.118.223867. doi: 10.2967/jnumed.118.223867. [Epub ahead of print]

PMID:
31101744
12.

Kinetic evaluation and test-retest reproducibility of [11C]UCB-J, a novel radioligand for positron emission tomography imaging of synaptic vesicle glycoprotein 2A in humans.

Finnema SJ, Nabulsi NB, Mercier J, Lin SF, Chen MK, Matuskey D, Gallezot JD, Henry S, Hannestad J, Huang Y, Carson RE.

J Cereb Blood Flow Metab. 2018 Nov;38(11):2041-2052. doi: 10.1177/0271678X17724947. Epub 2017 Aug 9.

PMID:
28792356
13.

[(11)C]UCB-A, a novel PET tracer for synaptic vesicle protein 2A.

Estrada S, Lubberink M, Thibblin A, Sprycha M, Buchanan T, Mestdagh N, Kenda B, Mercier J, Provins L, Gillard M, Tytgat D, Antoni G.

Nucl Med Biol. 2016 Jun;43(6):325-32. doi: 10.1016/j.nucmedbio.2016.03.004. Epub 2016 Mar 17.

PMID:
27260773
14.

Evaluating the In Vivo Specificity of [18F]UCB-H for the SV2A Protein, Compared with SV2B and SV2C in Rats Using microPET.

Serrano ME, Becker G, Bahri MA, Seret A, Mestdagh N, Mercier J, Mievis F, Giacomelli F, Lemaire C, Salmon E, Luxen A, Plenevaux A.

Molecules. 2019 May 1;24(9). pii: E1705. doi: 10.3390/molecules24091705.

15.

Quantifying SV2A density and drug occupancy in the human brain using [11C]UCB-J PET imaging and subcortical white matter as reference tissue.

Koole M, van Aalst J, Devrome M, Mertens N, Serdons K, Lacroix B, Mercier J, Sciberras D, Maguire P, Van Laere K.

Eur J Nucl Med Mol Imaging. 2019 Feb;46(2):396-406. doi: 10.1007/s00259-018-4119-8. Epub 2018 Aug 18.

PMID:
30121895
16.

Validation of Parametric Methods for [11C]UCB-J PET Imaging Using Subcortical White Matter as Reference Tissue.

Mertens N, Maguire RP, Serdons K, Lacroix B, Mercier J, Sciberras D, Van Laere K, Koole M.

Mol Imaging Biol. 2019 Jun 17. doi: 10.1007/s11307-019-01387-6. [Epub ahead of print]

PMID:
31209780
17.

Biodistribution and Radiation Dosimetry for the Novel SV2A Radiotracer [(18)F]UCB-H: First-in-Human Study.

Bretin F, Bahri MA, Bernard C, Warnock G, Aerts J, Mestdagh N, Buchanan T, Otoul C, Koestler F, Mievis F, Giacomelli F, Degueldre C, Hustinx R, Luxen A, Seret A, Plenevaux A, Salmon E.

Mol Imaging Biol. 2015 Aug;17(4):557-64. doi: 10.1007/s11307-014-0820-6.

PMID:
25595813
18.

Quantification of [18F]UCB-H Binding in the Rat Brain: From Kinetic Modelling to Standardised Uptake Value.

Serrano ME, Bahri MA, Becker G, Seret A, Mievis F, Giacomelli F, Lemaire C, Salmon E, Luxen A, Plenevaux A.

Mol Imaging Biol. 2018 Nov 20. doi: 10.1007/s11307-018-1301-0. [Epub ahead of print]

PMID:
30460626
19.

Imaging synaptic density in the living human brain.

Finnema SJ, Nabulsi NB, Eid T, Detyniecki K, Lin SF, Chen MK, Dhaher R, Matuskey D, Baum E, Holden D, Spencer DD, Mercier J, Hannestad J, Huang Y, Carson RE.

Sci Transl Med. 2016 Jul 20;8(348):348ra96. doi: 10.1126/scitranslmed.aaf6667.

PMID:
27440727
20.

A Novel 18F-Labeled Radioligand for Positron Emission Tomography Imaging of 11β-Hydroxysteroid Dehydrogenase (11β-HSD1): Synthesis and Preliminary Evaluation in Nonhuman Primates.

Baum E, Zhang W, Li S, Cai Z, Holden D, Huang Y.

ACS Chem Neurosci. 2019 May 15;10(5):2450-2458. doi: 10.1021/acschemneuro.8b00715. Epub 2019 Feb 19.

PMID:
30689943

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