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Metabolomic profile of diet-induced obesity mice in response to humanin and small humanin-like peptide 2 treatment.

Mehta HH, Xiao J, Ramirez R, Miller B, Kim SJ, Cohen P, Yen K.

Metabolomics. 2019 Jun 6;15(6):88. doi: 10.1007/s11306-019-1549-7.


Naturally occurring mitochondrial-derived peptides are age-dependent regulators of apoptosis, insulin sensitivity, and inflammatory markers.

Cobb LJ, Lee C, Xiao J, Yen K, Wong RG, Nakamura HK, Mehta HH, Gao Q, Ashur C, Huffman DM, Wan J, Muzumdar R, Barzilai N, Cohen P.

Aging (Albany NY). 2016 Apr;8(4):796-809. doi: 10.18632/aging.100943.


The Mitochondrial-Derived Peptides, HumaninS14G and Small Humanin-like Peptide 2, Exhibit Chaperone-like Activity.

Okada AK, Teranishi K, Lobo F, Isas JM, Xiao J, Yen K, Cohen P, Langen R.

Sci Rep. 2017 Aug 10;7(1):7802. doi: 10.1038/s41598-017-08372-5.


Chronic treatment with the mitochondrial peptide humanin prevents age-related myocardial fibrosis in mice.

Qin Q, Mehta H, Yen K, Navarrete G, Brandhorst S, Wan J, Delrio S, Zhang X, Lerman LO, Cohen P, Lerman A.

Am J Physiol Heart Circ Physiol. 2018 Nov 1;315(5):H1127-H1136. doi: 10.1152/ajpheart.00685.2017. Epub 2018 Jul 13.


Low circulating levels of the mitochondrial-peptide hormone SHLP2: novel biomarker for prostate cancer risk.

Xiao J, Howard L, Wan J, Wiggins E, Vidal A, Cohen P, Freedland SJ.

Oncotarget. 2017 Aug 10;8(55):94900-94909. doi: 10.18632/oncotarget.20134. eCollection 2017 Nov 7.


Characterizing the protective effects of SHLP2, a mitochondrial-derived peptide, in macular degeneration.

Nashine S, Cohen P, Nesburn AB, Kuppermann BD, Kenney MC.

Sci Rep. 2018 Oct 11;8(1):15175. doi: 10.1038/s41598-018-33290-5.


The Potent Humanin Analogue (HNG) Protects Germ Cells and Leucocytes While Enhancing Chemotherapy-Induced Suppression of Cancer Metastases in Male Mice.

Lue Y, Swerdloff R, Wan J, Xiao J, French S, Atienza V, Canela V, Bruhn KW, Stone B, Jia Y, Cohen P, Wang C.

Endocrinology. 2015 Dec;156(12):4511-21. doi: 10.1210/en.2015-1542. Epub 2015 Sep 18.


Mitochondrial-Derived Peptides Exacerbate Senescence.

Mendelsohn AR, Larrick JW.

Rejuvenation Res. 2018 Aug;21(4):369-373. doi: 10.1089/rej.2018.2114. Review.


Humanin analogue, S14G-humanin, has neuroprotective effects against oxygen glucose deprivation/reoxygenation by reactivating Jak2/Stat3 signaling through the PI3K/AKT pathway.

Gao GS, Li Y, Zhai H, Bi JW, Zhang FS, Zhang XY, Fan SH.

Exp Ther Med. 2017 Oct;14(4):3926-3934. doi: 10.3892/etm.2017.4934. Epub 2017 Aug 16.


Cytoprotective role of S14G-humanin (HNG) in ultraviolet-B induced epidermal stem cells injury.

Wang X, Liu X, Zhao Y, Sun H, Wang Y.

Biomed Pharmacother. 2019 Feb;110:248-253. doi: 10.1016/j.biopha.2018.11.059. Epub 2018 Nov 30.


Pharmacokinetics and tissue distribution of humanin and its analogues in male rodents.

Chin YP, Keni J, Wan J, Mehta H, Anene F, Jia Y, Lue YH, Swerdloff R, Cobb LJ, Wang C, Cohen P.

Endocrinology. 2013 Oct;154(10):3739-44. doi: 10.1210/en.2012-2004. Epub 2013 Jul 8.


Mitochondrial peptides modulate mitochondrial function during cellular senescence.

Kim SJ, Mehta HH, Wan J, Kuehnemann C, Chen J, Hu JF, Hoffman AR, Cohen P.

Aging (Albany NY). 2018 Jun 10;10(6):1239-1256. doi: 10.18632/aging.101463.


A humanin analog decreases oxidative stress and preserves mitochondrial integrity in cardiac myoblasts.

Klein LE, Cui L, Gong Z, Su K, Muzumdar R.

Biochem Biophys Res Commun. 2013 Oct 18;440(2):197-203. doi: 10.1016/j.bbrc.2013.08.055. Epub 2013 Aug 25.


IGF-I regulates the age-dependent signaling peptide humanin.

Lee C, Wan J, Miyazaki B, Fang Y, Guevara-Aguirre J, Yen K, Longo V, Bartke A, Cohen P.

Aging Cell. 2014 Oct;13(5):958-61. doi: 10.1111/acel.12243. Epub 2014 Jul 18.


The Neurovascular Protective Effect of S14G-Humanin in a Murine MCAO Model and Brain Endothelial Cells.

Peng T, Wan W, Wang J, Liu Y, Fu Z, Ma X, Li J, Sun G, Ji Y, Lu J, Lu H, Liu Y.

IUBMB Life. 2018 Jul;70(7):691-699. doi: 10.1002/iub.1869.


S14G-humanin improves cognitive deficits and reduces amyloid pathology in the middle-aged APPswe/PS1dE9 mice.

Zhang W, Zhang W, Li Z, Hao J, Zhang Z, Liu L, Mao N, Miao J, Zhang L.

Pharmacol Biochem Behav. 2012 Jan;100(3):361-9. doi: 10.1016/j.pbb.2011.09.012. Epub 2011 Oct 2.


Acute humanin therapy attenuates myocardial ischemia and reperfusion injury in mice.

Muzumdar RH, Huffman DM, Calvert JW, Jha S, Weinberg Y, Cui L, Nemkal A, Atzmon G, Klein L, Gundewar S, Ji SY, Lavu M, Predmore BL, Lefer DJ.

Arterioscler Thromb Vasc Biol. 2010 Oct;30(10):1940-8. doi: 10.1161/ATVBAHA.110.205997. Epub 2010 Jul 22.


S14G-humanin alleviates insulin resistance and increases autophagy in neurons of APP/PS1 transgenic mouse.

Han K, Jia N, Zhong Y, Shang X.

J Cell Biochem. 2018 Apr;119(4):3111-3117. doi: 10.1002/jcb.26452. Epub 2017 Dec 26.


S14G-Humanin ameliorates Abeta25-35-induced behavioral deficits by reducing neuroinflammatory responses and apoptosis in mice.

Miao J, Zhang W, Yin R, Liu R, Su C, Lei G, Li Z.

Neuropeptides. 2008 Oct-Dec;42(5-6):557-67. doi: 10.1016/j.npep.2008.08.004. Epub 2008 Oct 16. Retraction in: Neuropeptides. 2016 Apr;56:125.


Humanin: Functional Interfaces with IGF-I.

Xiao J, Kim SJ, Cohen P, Yen K.

Growth Horm IGF Res. 2016 Aug;29:21-27. doi: 10.1016/j.ghir.2016.03.005. Epub 2016 Apr 7. Review.

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