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SIRT1 protects cochlear hair cell and delays age-related hearing loss via autophagy.

Pang J, Xiong H, Ou Y, Yang H, Xu Y, Chen S, Lai L, Ye Y, Su Z, Lin H, Huang Q, Xu X, Zheng Y.

Neurobiol Aging. 2019 Apr 15;80:127-137. doi: 10.1016/j.neurobiolaging.2019.04.003. [Epub ahead of print]


Sirt1 deficiency protects cochlear cells and delays the early onset of age-related hearing loss in C57BL/6 mice.

Han C, Linser P, Park HJ, Kim MJ, White K, Vann JM, Ding D, Prolla TA, Someya S.

Neurobiol Aging. 2016 Jul;43:58-71. doi: 10.1016/j.neurobiolaging.2016.03.023. Epub 2016 Mar 30.


Modulation of miR-34a/SIRT1 signaling protects cochlear hair cells against oxidative stress and delays age-related hearing loss through coordinated regulation of mitophagy and mitochondrial biogenesis.

Xiong H, Chen S, Lai L, Yang H, Xu Y, Pang J, Su Z, Lin H, Zheng Y.

Neurobiol Aging. 2019 Jul;79:30-42. doi: 10.1016/j.neurobiolaging.2019.03.013. Epub 2019 Mar 27.


Activation of miR-34a impairs autophagic flux and promotes cochlear cell death via repressing ATG9A: implications for age-related hearing loss.

Pang J, Xiong H, Lin P, Lai L, Yang H, Liu Y, Huang Q, Chen S, Ye Y, Sun Y, Zheng Y.

Cell Death Dis. 2017 Oct 5;8(10):e3079. doi: 10.1038/cddis.2017.462.


Activation of miR-34a/SIRT1/p53 signaling contributes to cochlear hair cell apoptosis: implications for age-related hearing loss.

Xiong H, Pang J, Yang H, Dai M, Liu Y, Ou Y, Huang Q, Chen S, Zhang Z, Xu Y, Lai L, Zheng Y.

Neurobiol Aging. 2015 Apr;36(4):1692-1701. doi: 10.1016/j.neurobiolaging.2014.12.034. Epub 2015 Jan 6.


Sirtuin 1 and Autophagy Attenuate Cisplatin-Induced Hair Cell Death in the Mouse Cochlea and Zebrafish Lateral Line.

Pang J, Xiong H, Zhan T, Cheng G, Jia H, Ye Y, Su Z, Chen H, Lin H, Lai L, Ou Y, Xu Y, Chen S, Huang Q, Liang M, Cai Y, Zhang X, Xu X, Zheng Y, Yang H.

Front Cell Neurosci. 2019 Jan 14;12:515. doi: 10.3389/fncel.2018.00515. eCollection 2018.


PINK1 Protects Auditory Hair Cells and Spiral Ganglion Neurons from Cisplatin-induced Ototoxicity via Inducing Autophagy and Inhibiting JNK Signaling Pathway.

Yang Q, Sun G, Yin H, Li H, Cao Z, Wang J, Zhou M, Wang H, Li J.

Free Radic Biol Med. 2018 May 20;120:342-355. doi: 10.1016/j.freeradbiomed.2018.02.025. Epub 2018 Feb 17.


Induction of mitophagy in the HEI-OC1 auditory cell line and activation of the Atg12/LC3 pathway in the organ of Corti.

Setz C, Benischke AS, Pinho Ferreira Bento AC, Brand Y, Levano S, Paech F, Leitmeyer K, Bodmer D.

Hear Res. 2018 Apr;361:52-65. doi: 10.1016/j.heares.2018.01.003. Epub 2018 Jan 11.


miR-29b overexpression induces cochlear hair cell apoptosis through the regulation of SIRT1/PGC-1α signaling: Implications for age-related hearing loss.

Xue T, Wei L, Zha DJ, Qiu JH, Chen FQ, Qiao L, Qiu Y.

Int J Mol Med. 2016 Nov;38(5):1387-1394. doi: 10.3892/ijmm.2016.2735. Epub 2016 Sep 14.


MiR-34a contributes to diabetes-related cochlear hair cell apoptosis via SIRT1/HIF-1α signaling.

Lin Y, Shen J, Li D, Ming J, Liu X, Zhang N, Lai J, Shi M, Ji Q, Xing Y.

Gen Comp Endocrinol. 2017 May 15;246:63-70. doi: 10.1016/j.ygcen.2017.02.017. Epub 2017 Mar 2.


Activation of NLRX1-mediated autophagy accelerates the ototoxic potential of cisplatin in auditory cells.

Yin H, Yang Q, Cao Z, Li H, Yu Z, Zhang G, Sun G, Man R, Wang H, Li J.

Toxicol Appl Pharmacol. 2018 Mar 15;343:16-28. doi: 10.1016/j.taap.2018.02.007. Epub 2018 Feb 14.


Rs1894720 polymorphism in MIAT increased susceptibility to age-related hearing loss by modulating the activation of miR-29b/SIRT1/PGC-1α signaling.

Hao S, Wang L, Zhao K, Zhu X, Ye F.

J Cell Biochem. 2019 Apr;120(4):4975-4986. doi: 10.1002/jcb.27773. Epub 2018 Dec 16.


Resveratrol and caloric restriction prevent hepatic steatosis by regulating SIRT1-autophagy pathway and alleviating endoplasmic reticulum stress in high-fat diet-fed rats.

Ding S, Jiang J, Zhang G, Bu Y, Zhang G, Zhao X.

PLoS One. 2017 Aug 17;12(8):e0183541. doi: 10.1371/journal.pone.0183541. eCollection 2017.


Separate and combined effects of Sod1 and Cdh23 mutations on age-related hearing loss and cochlear pathology in C57BL/6J mice.

Johnson KR, Yu H, Ding D, Jiang H, Gagnon LH, Salvi RJ.

Hear Res. 2010 Sep 1;268(1-2):85-92. doi: 10.1016/j.heares.2010.05.002. Epub 2010 May 12.


Genetic background effects on age-related hearing loss associated with Cdh23 variants in mice.

Kane KL, Longo-Guess CM, Gagnon LH, Ding D, Salvi RJ, Johnson KR.

Hear Res. 2012 Jan;283(1-2):80-8. doi: 10.1016/j.heares.2011.11.007. Epub 2011 Nov 22.


Resveratrol protects HUVECs from oxidized-LDL induced oxidative damage by autophagy upregulation via the AMPK/SIRT1 pathway.

Guo H, Chen Y, Liao L, Wu W.

Cardiovasc Drugs Ther. 2013 Jun;27(3):189-98. doi: 10.1007/s10557-013-6442-4.


Deficiency in the mitochondrial apoptotic pathway reveals the toxic potential of autophagy under ER stress conditions.

Deegan S, Saveljeva S, Logue SE, Pakos-Zebrucka K, Gupta S, Vandenabeele P, Bertrand MJ, Samali A.

Autophagy. 2014;10(11):1921-36. doi: 10.4161/15548627.2014.981790.


SIRT1 protects the heart from ER stress-induced cell death through eIF2α deacetylation.

Prola A, Pires Da Silva J, Guilbert A, Lecru L, Piquereau J, Ribeiro M, Mateo P, Gressette M, Fortin D, Boursier C, Gallerne C, Caillard A, Samuel JL, François H, Sinclair DA, Eid P, Ventura-Clapier R, Garnier A, Lemaire C.

Cell Death Differ. 2017 Feb;24(2):343-356. doi: 10.1038/cdd.2016.138. Epub 2016 Dec 2.


Sirtuin1 and autophagy protect cells from fluoride-induced cell stress.

Suzuki M, Bartlett JD.

Biochim Biophys Acta. 2014 Feb;1842(2):245-55. doi: 10.1016/j.bbadis.2013.11.023. Epub 2013 Dec 1.


Meclofenamic Acid Reduces Reactive Oxygen Species Accumulation and Apoptosis, Inhibits Excessive Autophagy, and Protects Hair Cell-Like HEI-OC1 Cells From Cisplatin-Induced Damage.

Li H, Song Y, He Z, Chen X, Wu X, Li X, Bai X, Liu W, Li B, Wang S, Han Y, Xu L, Zhang D, Li J, Chai R, Wang H, Fan Z.

Front Cell Neurosci. 2018 May 23;12:139. doi: 10.3389/fncel.2018.00139. eCollection 2018.

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