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Activation of Mevalonate Pathway via LKB1 Is Essential for Stability of Treg Cells.

Timilshina M, You Z, Lacher SM, Acharya S, Jiang L, Kang Y, Kim JA, Chang HW, Kim KJ, Park B, Song JH, Ko HJ, Park YY, Ma MJ, Nepal MR, Jeong TC, Chung Y, Waisman A, Chang JH.

Cell Rep. 2019 Jun 4;27(10):2948-2961.e7. doi: 10.1016/j.celrep.2019.05.020.


Homeostatic control of metabolic and functional fitness of Treg cells by LKB1 signalling.

Yang K, Blanco DB, Neale G, Vogel P, Avila J, Clish CB, Wu C, Shrestha S, Rankin S, Long L, Kc A, Chi H.

Nature. 2017 Aug 31;548(7669):602-606. doi: 10.1038/nature23665. Epub 2017 Aug 23.


The liver kinase B1 is a central regulator of T cell development, activation, and metabolism.

MacIver NJ, Blagih J, Saucillo DC, Tonelli L, Griss T, Rathmell JC, Jones RG.

J Immunol. 2011 Oct 15;187(8):4187-98. doi: 10.4049/jimmunol.1100367. Epub 2011 Sep 19.


Metabolic control of regulatory T cell (Treg) survival and function by Lkb1.

He N, Fan W, Henriquez B, Yu RT, Atkins AR, Liddle C, Zheng Y, Downes M, Evans RM.

Proc Natl Acad Sci U S A. 2017 Nov 21;114(47):12542-12547. doi: 10.1073/pnas.1715363114. Epub 2017 Nov 6.


mTORC1 couples immune signals and metabolic programming to establish T(reg)-cell function.

Zeng H, Yang K, Cloer C, Neale G, Vogel P, Chi H.

Nature. 2013 Jul 25;499(7459):485-90. doi: 10.1038/nature12297. Epub 2013 Jun 30.


LKB1 expressed in dendritic cells governs the development and expansion of thymus-derived regulatory T cells.

Pelgrom LR, Patente TA, Sergushichev A, Esaulova E, Otto F, Ozir-Fazalalikhan A, van der Zande HJP, van der Ham AJ, van der Stel S, Artyomov MN, Everts B.

Cell Res. 2019 May;29(5):406-419. doi: 10.1038/s41422-019-0161-8. Epub 2019 Apr 2.


Regulation of Rac1 by simvastatin in endothelial cells: differential roles of AMP-activated protein kinase and calmodulin-dependent kinase kinase-beta.

Kou R, Sartoretto J, Michel T.

J Biol Chem. 2009 May 29;284(22):14734-43. doi: 10.1074/jbc.M808664200. Epub 2009 Mar 30.


Control of Treg cell homeostasis and immune equilibrium by Lkb1 in dendritic cells.

Chen S, Fang L, Guo W, Zhou Y, Yu G, Li W, Dong K, Liu J, Luo Y, Wang B, Li Z, Zhao C, Sun Z, Shen Y, Leng Q, Zhou D, Han Z, Huang H, Ren H, Xu G, Feng X.

Nat Commun. 2018 Dec 13;9(1):5298. doi: 10.1038/s41467-018-07545-8.


The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress.

Shaw RJ, Kosmatka M, Bardeesy N, Hurley RL, Witters LA, DePinho RA, Cantley LC.

Proc Natl Acad Sci U S A. 2004 Mar 9;101(10):3329-35. Epub 2004 Feb 25.


Activation of protein kinase C zeta by peroxynitrite regulates LKB1-dependent AMP-activated protein kinase in cultured endothelial cells.

Xie Z, Dong Y, Zhang M, Cui MZ, Cohen RA, Riek U, Neumann D, Schlattner U, Zou MH.

J Biol Chem. 2006 Mar 10;281(10):6366-75. Epub 2006 Jan 9.


Regulation of AMP-activated protein kinase by LKB1 and CaMKK in adipocytes.

Gormand A, Henriksson E, Ström K, Jensen TE, Sakamoto K, Göransson O.

J Cell Biochem. 2011 May;112(5):1364-75. doi: 10.1002/jcb.23053.


Liver Kinase B1/AMP-Activated Protein Kinase Pathway Activation Attenuated the Progression of Endotoxemia in the Diabetic Mice.

Yang Y, Dong R, Hu D, Chen Z, Fu M, Wang DW, Xu X, Tu L.

Cell Physiol Biochem. 2017;42(2):761-779. doi: 10.1159/000478068. Epub 2017 Jun 19.


An active metabolite of oltipraz (M2) increases mitochondrial fuel oxidation and inhibits lipogenesis in the liver by dually activating AMPK.

Kim TH, Eom JS, Lee CG, Yang YM, Lee YS, Kim SG.

Br J Pharmacol. 2013 Apr;168(7):1647-61. doi: 10.1111/bph.12057.


Mevalonate promotes differentiation of regulatory T cells.

Acharya S, Timilshina M, Chang JH.

J Mol Med (Berl). 2019 Jul;97(7):927-936. doi: 10.1007/s00109-019-01784-y. Epub 2019 Apr 24.


Liver kinase b1 is required for white adipose tissue growth and differentiation.

Zhang W, Wang Q, Song P, Zou MH.

Diabetes. 2013 Jul;62(7):2347-58. doi: 10.2337/db12-1229. Epub 2013 Feb 8.


Lovastatin induces multiple stress pathways including LKB1/AMPK activation that regulate its cytotoxic effects in squamous cell carcinoma cells.

Ma L, Niknejad N, Gorn-Hondermann I, Dayekh K, Dimitroulakos J.

PLoS One. 2012;7(9):e46055. doi: 10.1371/journal.pone.0046055. Epub 2012 Sep 28.


Liver kinase B1/adenosine monophosphate-activated protein kinase signaling axis induces p21/WAF1 expression in a p53-dependent manner.

Ma Q, Xiao P, Sun L, Wang J, Zhong D.

Oncol Lett. 2018 Jul;16(1):1291-1297. doi: 10.3892/ol.2018.8741. Epub 2018 May 18.


Deletion of Lkb1 in Renal Tubular Epithelial Cells Leads to CKD by Altering Metabolism.

Han SH, Malaga-Dieguez L, Chinga F, Kang HM, Tao J, Reidy K, Susztak K.

J Am Soc Nephrol. 2016 Feb;27(2):439-53. doi: 10.1681/ASN.2014121181. Epub 2015 Jun 8.

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