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Yeast ceramide synthases, Lag1 and Lac1, have distinct substrate specificity.

Megyeri M, Prasad R, Volpert G, Sliwa-Gonzalez A, Haribowo AG, Aguilera-Romero A, Riezman H, Barral Y, Futerman AH, Schuldiner M.

J Cell Sci. 2019 Jun 24;132(12). pii: jcs228411. doi: 10.1242/jcs.228411.


Differential regulation of ceramide synthase components LAC1 and LAG1 in Saccharomyces cerevisiae.

Kolaczkowski M, Kolaczkowska A, Gaigg B, Schneiter R, Moye-Rowley WS.

Eukaryot Cell. 2004 Aug;3(4):880-92.


Lag1p and Lac1p are essential for the Acyl-CoA-dependent ceramide synthase reaction in Saccharomyces cerevisae.

Schorling S, Vallée B, Barz WP, Riezman H, Oesterhelt D.

Mol Biol Cell. 2001 Nov;12(11):3417-27.


Suppressor analysis points to the subtle role of the LAG1 ceramide synthase gene in determining yeast longevity.

Jiang JC, Kirchman PA, Allen M, Jazwinski SM.

Exp Gerontol. 2004 Jul;39(7):999-1009.


Human homologues of LAG1 reconstitute Acyl-CoA-dependent ceramide synthesis in yeast.

Guillas I, Jiang JC, Vionnet C, Roubaty C, Uldry D, Chuard R, Wang J, Jazwinski SM, Conzelmann A.

J Biol Chem. 2003 Sep 26;278(39):37083-91. Epub 2003 Jul 17.


Functions of Ceramide Synthase Paralogs YPR114w and YJR116w of Saccharomyces cerevisiae.

Mallela SK, Almeida R, Ejsing CS, Conzelmann A.

PLoS One. 2016 Jan 11;11(1):e0145831. doi: 10.1371/journal.pone.0145831. eCollection 2016.


The longevity assurance homologue of yeast lag1 (Lass) gene family (review).

Teufel A, Maass T, Galle PR, Malik N.

Int J Mol Med. 2009 Feb;23(2):135-40. Review.


Two mammalian longevity assurance gene (LAG1) family members, trh1 and trh4, regulate dihydroceramide synthesis using different fatty acyl-CoA donors.

Riebeling C, Allegood JC, Wang E, Merrill AH Jr, Futerman AH.

J Biol Chem. 2003 Oct 31;278(44):43452-9. Epub 2003 Aug 11.


Regulation of ceramide synthase by casein kinase 2-dependent phosphorylation in Saccharomyces cerevisiae.

Fresques T, Niles B, Aronova S, Mogri H, Rakhshandehroo T, Powers T.

J Biol Chem. 2015 Jan 16;290(3):1395-403. doi: 10.1074/jbc.M114.621086. Epub 2014 Nov 26.


Yeast sphingolipids do not need to contain very long chain fatty acids.

Cerantola V, Vionnet C, Aebischer OF, Jenny T, Knudsen J, Conzelmann A.

Biochem J. 2007 Jan 1;401(1):205-16.


Following the flux of long-chain bases through the sphingolipid pathway in vivo using mass spectrometry.

Martínez-Montañés F, Schneiter R.

J Lipid Res. 2016 May;57(5):906-15. doi: 10.1194/jlr.D066472. Epub 2016 Mar 14.


Homologs of the yeast longevity gene LAG1 in Caenorhabditis elegans and human.

Jiang JC, Kirchman PA, Zagulski M, Hunt J, Jazwinski SM.

Genome Res. 1998 Dec;8(12):1259-72.


Phytoceramide and sphingoid bases derived from brewer's yeast Saccharomyces pastorianus activate peroxisome proliferator-activated receptors.

Murakami I, Wakasa Y, Yamashita S, Kurihara T, Zama K, Kobayashi N, Mizutani Y, Mitsutake S, Shigyo T, Igarashi Y.

Lipids Health Dis. 2011 Aug 24;10:150. doi: 10.1186/1476-511X-10-150.


Expression of LASS2 controlled by LAG1 or ADH1 promoters cannot functionally complement Lag1p.

Yu Y, Lu H, Pan H, Ma JH, Ding ZJ, Li YY.

Microbiol Res. 2006;161(3):203-11. Epub 2005 Sep 22.


The CLN9 protein, a regulator of dihydroceramide synthase.

Schulz A, Mousallem T, Venkataramani M, Persaud-Sawin DA, Zucker A, Luberto C, Bielawska A, Bielawski J, Holthuis JC, Jazwinski SM, Kozhaya L, Dbaibo GS, Boustany RM.

J Biol Chem. 2006 Feb 3;281(5):2784-94. Epub 2005 Nov 22.


Yeast cells lacking all known ceramide synthases continue to make complex sphingolipids and to incorporate ceramides into glycosylphosphatidylinositol (GPI) anchors.

Vionnet C, Roubaty C, Ejsing CS, Knudsen J, Conzelmann A.

J Biol Chem. 2011 Feb 25;286(8):6769-79. doi: 10.1074/jbc.M110.176875. Epub 2010 Dec 20.


Genetic analysis of hyl-1, the C. elegans homolog of LAG1/LASS1.

Tedesco P, Jiang J, Wang J, Jazwinski SM, Johnson TE.

Age (Dordr). 2008 Mar;30(1):43-52. doi: 10.1007/s11357-008-9046-3. Epub 2008 Feb 16.


Mitochondria to nucleus signaling and the role of ceramide in its integration into the suite of cell quality control processes during aging.

Jazwinski SM.

Ageing Res Rev. 2015 Sep;23(Pt A):67-74. doi: 10.1016/j.arr.2014.12.007. Epub 2014 Dec 31. Review.

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