Format
Sort by
Items per page

Send to

Choose Destination

Links from PubMed

Items: 1 to 20 of 98

1.

Identification of inhibitors of an unconventional Trypanosoma brucei kinetochore kinase.

Torrie LS, Zuccotto F, Robinson DA, Gray DW, Gilbert IH, De Rycker M.

PLoS One. 2019 May 31;14(5):e0217828. doi: 10.1371/journal.pone.0217828. eCollection 2019.

2.

Divergent polo box domains underpin the unique kinetoplastid kinetochore.

Nerusheva OO, Akiyoshi B.

Open Biol. 2016 Mar;6(3). pii: 150206. doi: 10.1098/rsob.150206.

3.

Discovery of unconventional kinetochores in kinetoplastids.

Akiyoshi B, Gull K.

Cell. 2014 Mar 13;156(6):1247-1258. doi: 10.1016/j.cell.2014.01.049. Epub 2014 Feb 27.

4.

Identification and characterization of hundreds of potent and selective inhibitors of Trypanosoma brucei growth from a kinase-targeted library screening campaign.

Diaz R, Luengo-Arratta SA, Seixas JD, Amata E, Devine W, Cordon-Obras C, Rojas-Barros DI, Jimenez E, Ortega F, Crouch S, Colmenarejo G, Fiandor JM, Martin JJ, Berlanga M, Gonzalez S, Manzano P, Navarro M, Pollastri MP.

PLoS Negl Trop Dis. 2014 Oct 23;8(10):e3253. doi: 10.1371/journal.pntd.0003253. eCollection 2014 Oct.

5.

Identification of compounds with anti-proliferative activity against Trypanosoma brucei brucei strain 427 by a whole cell viability based HTS campaign.

Sykes ML, Baell JB, Kaiser M, Chatelain E, Moawad SR, Ganame D, Ioset JR, Avery VM.

PLoS Negl Trop Dis. 2012;6(11):e1896. doi: 10.1371/journal.pntd.0001896. Epub 2012 Nov 29.

6.

Discovery and antiparasitic activity of AZ960 as a Trypanosoma brucei ERK8 inhibitor.

Valenciano AL, Ramsey AC, Santos WL, Mackey ZB.

Bioorg Med Chem. 2016 Oct 1;24(19):4647-4651. doi: 10.1016/j.bmc.2016.07.069. Epub 2016 Aug 1.

PMID:
27519462
7.

Screening a Natural Product-Based Library against Kinetoplastid Parasites.

Zulfiqar B, Jones AJ, Sykes ML, Shelper TB, Davis RA, Avery VM.

Molecules. 2017 Oct 12;22(10). pii: E1715. doi: 10.3390/molecules22101715.

8.

Drug discovery for human African trypanosomiasis: identification of novel scaffolds by the newly developed HTS SYBR Green assay for Trypanosoma brucei.

Faria J, Moraes CB, Song R, Pascoalino BS, Lee N, Siqueira-Neto JL, Cruz DJ, Parkinson T, Ioset JR, Cordeiro-da-Silva A, Freitas-Junior LH.

J Biomol Screen. 2015 Jan;20(1):70-81. doi: 10.1177/1087057114556236. Epub 2014 Oct 23.

PMID:
25342146
9.

Identification of Trypanosoma brucei AdoMetDC Inhibitors Using a High-Throughput Mass Spectrometry-Based Assay.

Volkov OA, Cosner CC, Brockway AJ, Kramer M, Booker M, Zhong S, Ketcherside A, Wei S, Longgood J, McCoy M, Richardson TE, Wring SA, Peel M, Klinger JD, Posner BA, De Brabander JK, Phillips MA.

ACS Infect Dis. 2017 Jul 14;3(7):512-526. doi: 10.1021/acsinfecdis.7b00022. Epub 2017 Apr 7.

10.

Biological characterization of chemically diverse compounds targeting the Plasmodium falciparum coenzyme A synthesis pathway.

Fletcher S, Lucantoni L, Sykes ML, Jones AJ, Holleran JP, Saliba KJ, Avery VM.

Parasit Vectors. 2016 Nov 17;9(1):589.

11.

From on-target to off-target activity: identification and optimisation of Trypanosoma brucei GSK3 inhibitors and their characterisation as anti-Trypanosoma brucei drug discovery lead molecules.

Woodland A, Grimaldi R, Luksch T, Cleghorn LA, Ojo KK, Van Voorhis WC, Brenk R, Frearson JA, Gilbert IH, Wyatt PG.

ChemMedChem. 2013 Jul;8(7):1127-37. doi: 10.1002/cmdc.201300072. Epub 2013 Jun 14.

12.

Safety screening in early drug discovery: An optimized assay panel.

Bendels S, Bissantz C, Fasching B, Gerebtzoff G, Guba W, Kansy M, Migeon J, Mohr S, Peters JU, Tillier F, Wyler R, Lerner C, Kramer C, Richter H, Roberts S.

J Pharmacol Toxicol Methods. 2019 Jul 5:106609. doi: 10.1016/j.vascn.2019.106609. [Epub ahead of print]

PMID:
31284073
13.

3-(Oxazolo[4,5-b]pyridin-2-yl)anilides as a novel class of potent inhibitors for the kinetoplastid Trypanosoma brucei, the causative agent for human African trypanosomiasis.

Ferrins L, Rahmani R, Sykes ML, Jones AJ, Avery VM, Teston E, Almohaywi B, Yin J, Smith J, Hyland C, White KL, Ryan E, Campbell M, Charman SA, Kaiser M, Baell JB.

Eur J Med Chem. 2013 Aug;66:450-65. doi: 10.1016/j.ejmech.2013.05.007. Epub 2013 May 16.

PMID:
23831695
14.

6-Arylpyrazine-2-carboxamides: A New Core for Trypanosoma brucei Inhibitors.

Rahmani R, Ban K, Jones AJ, Ferrins L, Ganame D, Sykes ML, Avery VM, White KL, Ryan E, Kaiser M, Charman SA, Baell JB.

J Med Chem. 2015 Sep 10;58(17):6753-65. doi: 10.1021/acs.jmedchem.5b00438. Epub 2015 Aug 30.

PMID:
26247439
15.

Design, synthesis and biological evaluation of potent azadipeptide nitrile inhibitors and activity-based probes as promising anti-Trypanosoma brucei agents.

Yang PY, Wang M, Li L, Wu H, He CY, Yao SQ.

Chemistry. 2012 May 21;18(21):6528-41. doi: 10.1002/chem.201103322. Epub 2012 Apr 4.

PMID:
22488888
16.

Lapatinib-binding protein kinases in the African trypanosome: identification of cellular targets for kinase-directed chemical scaffolds.

Katiyar S, Kufareva I, Behera R, Thomas SM, Ogata Y, Pollastri M, Abagyan R, Mensa-Wilmot K.

PLoS One. 2013;8(2):e56150. doi: 10.1371/journal.pone.0056150. Epub 2013 Feb 20. Erratum in: PLoS One. 2014;9(3):e92488.

17.

Novel 1,2-dihydroquinazolin-2-ones: Design, synthesis, and biological evaluation against Trypanosoma brucei.

Pham T, Walden M, Butler C, Diaz-Gonzalez R, Pérez-Moreno G, Ceballos-Pérez G, Gomez-Pérez V, García-Hernández R, Zecca H, Krakoff E, Kopec B, Ichire O, Mackenzie C, Pitot M, Ruiz LM, Gamarro F, González-Pacanowska D, Navarro M, Dounay AB.

Bioorg Med Chem Lett. 2017 Aug 15;27(16):3629-3635. doi: 10.1016/j.bmcl.2017.07.032. Epub 2017 Jul 11.

18.

The MAP kinase MAPKLK1 is essential to Trypanosoma brucei proliferation and regulates proteins involved in mRNA metabolism.

Batista M, Kugeratski FG, de Paula Lima CV, Probst CM, Kessler RL, de Godoy LM, Krieger MA, Marchini FK.

J Proteomics. 2017 Feb 10;154:118-127. doi: 10.1016/j.jprot.2016.12.011. Epub 2016 Dec 27.

PMID:
28039027
19.

A high-throughput, nonisotopic, competitive binding assay for kinases using nonselective inhibitor probes (ED-NSIP).

Vainshtein I, Silveria S, Kaul P, Rouhani R, Eglen RM, Wang J.

J Biomol Screen. 2002 Dec;7(6):507-14.

PMID:
14599348
20.

Discovery of Inhibitors of Trypanosoma brucei by Phenotypic Screening of a Focused Protein Kinase Library.

Woodland A, Thompson S, Cleghorn LA, Norcross N, De Rycker M, Grimaldi R, Hallyburton I, Rao B, Norval S, Stojanovski L, Brun R, Kaiser M, Frearson JA, Gray DW, Wyatt PG, Read KD, Gilbert IH.

ChemMedChem. 2015 Nov;10(11):1809-20. doi: 10.1002/cmdc.201500300. Epub 2015 Sep 18.

Supplemental Content

Support Center