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Items: 1 to 20 of 101

1.

Mitochondrial metabolism promotes adaptation to proteotoxic stress.

Tsvetkov P, Detappe A, Cai K, Keys HR, Brune Z, Ying W, Thiru P, Reidy M, Kugener G, Rossen J, Kocak M, Kory N, Tsherniak A, Santagata S, Whitesell L, Ghobrial IM, Markley JL, Lindquist S, Golub TR.

Nat Chem Biol. 2019 Jul;15(7):681-689. doi: 10.1038/s41589-019-0291-9. Epub 2019 May 27. Erratum in: Nat Chem Biol. 2019 Jun 4;:.

PMID:
31133756
2.

Small-molecule RA-9 inhibits proteasome-associated DUBs and ovarian cancer in vitro and in vivo via exacerbating unfolded protein responses.

Coughlin K, Anchoori R, Iizuka Y, Meints J, MacNeill L, Vogel RI, Orlowski RZ, Lee MK, Roden RB, Bazzaro M.

Clin Cancer Res. 2014 Jun 15;20(12):3174-86. doi: 10.1158/1078-0432.CCR-13-2658. Epub 2014 Apr 11.

3.

Regulated Cell Death of Lymphoma Cells after Graded Mitochondrial Damage is Differentially Affected by Drugs Targeting Cell Stress Responses.

Lombardo T, Folgar MG, Salaverry L, Rey-Roldán E, Alvarez EM, Carreras MC, Kornblihtt L, Blanco GA.

Basic Clin Pharmacol Toxicol. 2018 May;122(5):489-500. doi: 10.1111/bcpt.12945. Epub 2018 Jan 3.

4.

Inhibition of stress-inducible HSP70 impairs mitochondrial proteostasis and function.

Leu JI, Barnoud T, Zhang G, Tian T, Wei Z, Herlyn M, Murphy ME, George DL.

Oncotarget. 2017 Jul 11;8(28):45656-45669. doi: 10.18632/oncotarget.17321.

5.

The oncology drug elesclomol selectively transports copper to the mitochondria to induce oxidative stress in cancer cells.

Nagai M, Vo NH, Shin Ogawa L, Chimmanamada D, Inoue T, Chu J, Beaudette-Zlatanova BC, Lu R, Blackman RK, Barsoum J, Koya K, Wada Y.

Free Radic Biol Med. 2012 May 15;52(10):2142-50. doi: 10.1016/j.freeradbiomed.2012.03.017. Epub 2012 Apr 17.

PMID:
22542443
6.

Proteasome inhibitors with pyrazole scaffolds from structure-based virtual screening.

Miller Z, Kim KS, Lee DM, Kasam V, Baek SE, Lee KH, Zhang YY, Ao L, Carmony K, Lee NR, Zhou S, Zhao Q, Jang Y, Jeong HY, Zhan CG, Lee W, Kim DE, Kim KB.

J Med Chem. 2015 Feb 26;58(4):2036-41. doi: 10.1021/jm501344n. Epub 2015 Feb 17.

PMID:
25658656
7.

TCF11/Nrf1-Mediated Induction of Proteasome Expression Prevents Cytotoxicity by Rotenone.

Sotzny F, Schormann E, Kühlewindt I, Koch A, Brehm A, Goldbach-Mansky R, Gilling KE, Krüger E.

Antioxid Redox Signal. 2016 Dec 1;25(16):870-885. Epub 2016 Nov 14.

8.

Inactivation of the HIF-1α/PDK3 signaling axis drives melanoma toward mitochondrial oxidative metabolism and potentiates the therapeutic activity of pro-oxidants.

Kluza J, Corazao-Rozas P, Touil Y, Jendoubi M, Maire C, Guerreschi P, Jonneaux A, Ballot C, Balayssac S, Valable S, Corroyer-Dulmont A, Bernaudin M, Malet-Martino M, de Lassalle EM, Maboudou P, Formstecher P, Polakowska R, Mortier L, Marchetti P.

Cancer Res. 2012 Oct 1;72(19):5035-47. doi: 10.1158/0008-5472.CAN-12-0979. Epub 2012 Aug 3.

9.

The Small Molecules Targeting Ubiquitin-Proteasome System for Cancer Therapy.

Ao N, Chen Q, Liu G.

Comb Chem High Throughput Screen. 2017;20(5):403-413. doi: 10.2174/1386207320666170710124746. Review.

PMID:
28699494
10.

K(ATP) channel block prevents proteasome inhibitor-induced apoptosis in differentiated PC12 cells.

Nam YJ, Lee DH, Lee MS, Lee CS.

Eur J Pharmacol. 2015 Oct 5;764:582-91. doi: 10.1016/j.ejphar.2015.06.049. Epub 2015 Jul 2.

PMID:
26142827
11.

Intrinsic proteotoxic stress levels vary and act as a predictive marker for sensitivity of cancer cells to Hsp90 inhibition.

Pastorek M, Muller P, Coates PJ, Vojtesek B.

PLoS One. 2018 Aug 23;13(8):e0202758. doi: 10.1371/journal.pone.0202758. eCollection 2018.

12.

Lamotrigine Attenuates Proteasome Inhibition-Induced Apoptosis by Suppressing the Activation of the Mitochondrial Pathway and the Caspase-8- and Bid-Dependent Pathways.

Nam YJ, Kim A, Lee MS, Shin YK, Sohn DS, Lee CS.

Neurochem Res. 2016 Oct;41(10):2503-2516. Epub 2016 May 26.

PMID:
27230883
13.

Ritonavir, nelfinavir, saquinavir and lopinavir induce proteotoxic stress in acute myeloid leukemia cells and sensitize them for proteasome inhibitor treatment at low micromolar drug concentrations.

Kraus M, Müller-Ide H, Rückrich T, Bader J, Overkleeft H, Driessen C.

Leuk Res. 2014 Mar;38(3):383-92. doi: 10.1016/j.leukres.2013.12.017. Epub 2013 Dec 25.

PMID:
24418752
14.

Mitochondrial thioredoxin reductase regulates major cytotoxicity pathways of proteasome inhibitors in multiple myeloma cells.

Fink EE, Mannava S, Bagati A, Bianchi-Smiraglia A, Nair JR, Moparthy K, Lipchick BC, Drokov M, Utley A, Ross J, Mendeleeva LP, Savchenko VG, Lee KP, Nikiforov MA.

Leukemia. 2016 Jan;30(1):104-11. doi: 10.1038/leu.2015.190. Epub 2015 Jul 24.

15.

[The mechanism of proteasome inhibition-mediated mitochondrial impairment].

Hoseki J.

Seikagaku. 2016 Apr;88(2):211-4. Review. Japanese. No abstract available.

PMID:
27192873
16.

Identification of Novel Proteasome Inhibitors from an Enaminone Library.

Elliott ML, Thomas K, Kennedy S, Koduri ND, Hussaini RS, Sheaff RJ.

Chem Biol Drug Des. 2015 Sep;86(3):322-32. doi: 10.1111/cbdd.12496. Epub 2015 Jan 9.

PMID:
25494709
17.
18.

Persistent mitochondrial dysfunction and oxidative stress hinder neuronal cell recovery from reversible proteasome inhibition.

Papa L, Rockwell P.

Apoptosis. 2008 Apr;13(4):588-99. doi: 10.1007/s10495-008-0182-0.

PMID:
18299995
19.

Small-molecule control of intracellular protein levels through modulation of the ubiquitin proteasome system.

Buckley DL, Crews CM.

Angew Chem Int Ed Engl. 2014 Feb 24;53(9):2312-30. doi: 10.1002/anie.201307761. Epub 2014 Jan 23. Review.

20.

Discovery of new Mycobacterium tuberculosis proteasome inhibitors using a knowledge-based computational screening approach.

Mehra R, Chib R, Munagala G, Yempalla KR, Khan IA, Singh PP, Khan FG, Nargotra A.

Mol Divers. 2015 Nov;19(4):1003-19. doi: 10.1007/s11030-015-9624-0. Epub 2015 Aug 1. Erratum in: Mol Divers. 2016 Feb;20(1):367.

PMID:
26232029

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