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Triptolide exerts an anti-tumor effect on non‑small cell lung cancer cells by inhibiting activation of the IL‑6/STAT3 axis.

Huang Y, Chen Z, Wang Y, Ba X, Huang Y, Shen P, Wang H, Tu S.

Int J Mol Med. 2019 Jul;44(1):291-300. doi: 10.3892/ijmm.2019.4197. Epub 2019 May 14.


IL6-induced metastasis modulators p-STAT3, MMP-2 and MMP-9 are targets of 3,3'-diindolylmethane in ovarian cancer cells.

Zou M, Zhang X, Xu C.

Cell Oncol (Dordr). 2016 Feb;39(1):47-57. doi: 10.1007/s13402-015-0251-7. Epub 2015 Oct 28.


Triptolide exhibits antitumor effects by reversing hypermethylation of WIF‑1 in lung cancer cells.

Mao X, Tong J, Wang Y, Zhu Z, Yin Y, Wang Y.

Mol Med Rep. 2018 Sep;18(3):3041-3049. doi: 10.3892/mmr.2018.9263. Epub 2018 Jul 9.


Flubendazole demonstrates valid antitumor effects by inhibiting STAT3 and activating autophagy.

Lin S, Yang L, Yao Y, Xu L, Xiang Y, Zhao H, Wang L, Zuo Z, Huang X, Zhao C.

J Exp Clin Cancer Res. 2019 Jul 8;38(1):293. doi: 10.1186/s13046-019-1303-z.


Traditional Chinese medicine, Fuzheng Kang‑Ai decoction, inhibits metastasis of lung cancer cells through the STAT3/MMP9 pathway.

Li L, Wang S, Yang X, Long S, Xiao S, Wu W, Hann SS.

Mol Med Rep. 2017 Sep;16(3):2461-2468. doi: 10.3892/mmr.2017.6905. Epub 2017 Jun 30.


A sesquiterpene lactone antrocin from Antrodia camphorata negatively modulates JAK2/STAT3 signaling via microRNA let-7c and induces apoptosis in lung cancer cells.

Yeh CT, Huang WC, Rao YK, Ye M, Lee WH, Wang LS, Tzeng DT, Wu CH, Shieh YS, Huang CY, Chen YJ, Hsiao M, Wu AT, Yang Z, Tzeng YM.

Carcinogenesis. 2013 Dec;34(12):2918-28. doi: 10.1093/carcin/bgt255. Epub 2013 Jul 23.


ITRAQ-Based Proteomics Analysis of Triptolide On Human A549 Lung Adenocarcinoma Cells.

Li F, Zhao D, Yang S, Wang J, Liu Q, Jin X, Wang W.

Cell Physiol Biochem. 2018;45(3):917-934. doi: 10.1159/000487286. Epub 2018 Feb 2.


A novel small inhibitor, LLL12, targets STAT3 in non-small cell lung cancer in vitro and in vivo.

Nie Y, Li Y, Hu S.

Oncol Lett. 2018 Oct;16(4):5349-5354. doi: 10.3892/ol.2018.9262. Epub 2018 Aug 3.


Physalin A exerts anti-tumor activity in non-small cell lung cancer cell lines by suppressing JAK/STAT3 signaling.

Zhu F, Dai C, Fu Y, Loo JF, Xia D, Gao SP, Ma Z, Chen Z.

Oncotarget. 2016 Feb 23;7(8):9462-76. doi: 10.18632/oncotarget.7051.


Alpinetin inhibits proliferation and migration of ovarian cancer cells via suppression of STAT3 signaling.

Zhao X, Guo X, Shen J, Hua D.

Mol Med Rep. 2018 Oct;18(4):4030-4036. doi: 10.3892/mmr.2018.9420. Epub 2018 Aug 22.


Ethyl pyruvate suppresses the growth, invasion and migration and induces the apoptosis of non‑small cell lung cancer cells via the HMGB1/RAGE axis and the NF‑κB/STAT3 pathway.

Liu Q, Huo Y, Zheng H, Zhao J, Jia L, Wang P.

Oncol Rep. 2019 Aug;42(2):817-825. doi: 10.3892/or.2019.7176. Epub 2019 May 30.


Pterostilbene exerts antitumor activity against human osteosarcoma cells by inhibiting the JAK2/STAT3 signaling pathway.

Liu Y, Wang L, Wu Y, Lv C, Li X, Cao X, Yang M, Feng D, Luo Z.

Toxicology. 2013 Feb 8;304:120-31. doi: 10.1016/j.tox.2012.12.018. Epub 2013 Jan 8.


Rheum palmatum extract exerts anti-hepatocellular carcinoma effects by inhibiting signal transducer and activator of transcription 3 signaling.

Tan ZB, Fan HJ, Wu YT, Xie LP, Bi YM, Xu HL, Chen HM, Li J, Liu B, Zhou YC.

J Ethnopharmacol. 2019 Mar 25;232:62-72. doi: 10.1016/j.jep.2018.12.019. Epub 2018 Dec 13.


Enhancement of triptolide-loaded micelles on tumorigenicity inhibition of human ovarian cancer.

Wang Y, Liu T, Li H.

J Biomater Sci Polym Ed. 2016;27(7):545-56. doi: 10.1080/09205063.2015.1131667. Epub 2016 Mar 16.


Ginkgetin inhibits the growth of DU-145 prostate cancer cells through inhibition of signal transducer and activator of transcription 3 activity.

Jeon YJ, Jung SN, Yun J, Lee CW, Choi J, Lee YJ, Han DC, Kwon BM.

Cancer Sci. 2015 Apr;106(4):413-20. doi: 10.1111/cas.12608. Epub 2015 Feb 20.


Tyrphostin B42 attenuates trichostatin A-mediated resistance in pancreatic cancer cells by antagonizing IL-6/JAK2/STAT3 signaling.

Zhang X, Lu H, Hong W, Liu L, Wang S, Zhou M, Chen B, Bai Y.

Oncol Rep. 2018 Apr;39(4):1892-1900. doi: 10.3892/or.2018.6241. Epub 2018 Jan 31.


Sorafenib Sensitizes Glioma Cells to the BH3 Mimetic ABT-737 by Targeting MCL1 in a STAT3-Dependent Manner.

Kiprianova I, Remy J, Milosch N, Mohrenz IV, Seifert V, Aigner A, Kögel D.

Neoplasia. 2015 Jul;17(7):564-73. doi: 10.1016/j.neo.2015.07.003.


Niclosamide suppresses cell migration and invasion in enzalutamide resistant prostate cancer cells via Stat3-AR axis inhibition.

Liu C, Lou W, Armstrong C, Zhu Y, Evans CP, Gao AC.

Prostate. 2015 Sep;75(13):1341-53. doi: 10.1002/pros.23015. Epub 2015 May 13.


Cucurbitacin I inhibits tumorigenic ability and enhances radiochemosensitivity in nonsmall cell lung cancer-derived CD133-positive cells.

Hsu HS, Huang PI, Chang YL, Tzao C, Chen YW, Shih HC, Hung SC, Chen YC, Tseng LM, Chiou SH.

Cancer. 2011 Jul 1;117(13):2970-85. doi: 10.1002/cncr.25869. Epub 2011 Jan 10.


Metformin can block precancerous progression to invasive tumors of bladder through inhibiting STAT3-mediated signaling pathways.

Pan Q, Yang GL, Yang JH, Lin SL, Liu N, Liu SS, Liu MY, Zhang LH, Huang YR, Shen RL, Liu Q, Gao JX, Bo JJ.

J Exp Clin Cancer Res. 2015 Aug 7;34:77. doi: 10.1186/s13046-015-0183-0.

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