Similar articles for PMID: 31113940

Year	Number of Results
2013	3
2014	4
2015	7
2016	10
2017	20
2018	16
2019	20
2020	21
2021	11
2022	1
2023	4
2024	0

1

Development of human cGAS-specific small-molecule inhibitors for repression of dsDNA-triggered interferon expression.

Lama L, Adura C, Xie W, Tomita D, Kamei T, Kuryavyi V, Gogakos T, Steinberg JI, Miller M, Ramos-Espiritu L, Asano Y, Hashizume S, Aida J, Imaeda T, Okamoto R, Jennings AJ, Michino M, Kuroita T, Stamford A, Gao P, Meinke P, Glickman JF, Patel DJ, Tuschl T. Lama L, et al. Nat Commun. 2019 May 21;10(1):2261. doi: 10.1038/s41467-019-08620-4. Nat Commun. 2019. PMID: 31113940 Free PMC article.

2

Small molecule inhibition of cGAS reduces interferon expression in primary macrophages from autoimmune mice.

Vincent J, Adura C, Gao P, Luz A, Lama L, Asano Y, Okamoto R, Imaeda T, Aida J, Rothamel K, Gogakos T, Steinberg J, Reasoner S, Aso K, Tuschl T, Patel DJ, Glickman JF, Ascano M. Vincent J, et al. Nat Commun. 2017 Sep 29;8(1):750. doi: 10.1038/s41467-017-00833-9. Nat Commun. 2017. PMID: 28963528 Free PMC article.

3

Discovery of PF-06928215 as a high affinity inhibitor of cGAS enabled by a novel fluorescence polarization assay.

Hall J, Brault A, Vincent F, Weng S, Wang H, Dumlao D, Aulabaugh A, Aivazian D, Castro D, Chen M, Culp J, Dower K, Gardner J, Hawrylik S, Golenbock D, Hepworth D, Horn M, Jones L, Jones P, Latz E, Li J, Lin LL, Lin W, Lin D, Lovering F, Niljanskul N, Nistler R, Pierce B, Plotnikova O, Schmitt D, Shanker S, Smith J, Snyder W, Subashi T, Trujillo J, Tyminski E, Wang G, Wong J, Lefker B, Dakin L, Leach K. Hall J, et al. PLoS One. 2017 Sep 21;12(9):e0184843. doi: 10.1371/journal.pone.0184843. eCollection 2017. PLoS One. 2017. PMID: 28934246 Free PMC article.

4

Small molecule inhibition of human cGAS reduces total cGAMP output and cytokine expression in cells.

Wiser C, Kim B, Vincent J, Ascano M. Wiser C, et al. Sci Rep. 2020 May 5;10(1):7604. doi: 10.1038/s41598-020-64348-y. Sci Rep. 2020. PMID: 32371942 Free PMC article.

5

The catalytic mechanism of cyclic GMP-AMP synthase (cGAS) and implications for innate immunity and inhibition.

Hall J, Ralph EC, Shanker S, Wang H, Byrnes LJ, Horst R, Wong J, Brault A, Dumlao D, Smith JF, Dakin LA, Schmitt DC, Trujillo J, Vincent F, Griffor M, Aulabaugh AE. Hall J, et al. Protein Sci. 2017 Dec;26(12):2367-2380. doi: 10.1002/pro.3304. Epub 2017 Oct 25. Protein Sci. 2017. PMID: 28940468 Free PMC article.

6

Crosstalk between the cGAS DNA sensor and Beclin-1 autophagy protein shapes innate antimicrobial immune responses.

Liang Q, Seo GJ, Choi YJ, Kwak MJ, Ge J, Rodgers MA, Shi M, Leslie BJ, Hopfner KP, Ha T, Oh BH, Jung JU. Liang Q, et al. Cell Host Microbe. 2014 Feb 12;15(2):228-38. doi: 10.1016/j.chom.2014.01.009. Cell Host Microbe. 2014. PMID: 24528868 Free PMC article.

7

Perillaldehyde Inhibition of cGAS Reduces dsDNA-Induced Interferon Response.

Chu L, Li C, Li Y, Yu Q, Yu H, Li C, Meng W, Zhu J, Wang Q, Wang C, Cui S. Chu L, et al. Front Immunol. 2021 Apr 22;12:655637. doi: 10.3389/fimmu.2021.655637. eCollection 2021. Front Immunol. 2021. PMID: 33968056 Free PMC article.

8

ZCCHC3 is a co-sensor of cGAS for dsDNA recognition in innate immune response.

Lian H, Wei J, Zang R, Ye W, Yang Q, Zhang XN, Chen YD, Fu YZ, Hu MM, Lei CQ, Luo WW, Li S, Shu HB. Lian H, et al. Nat Commun. 2018 Aug 22;9(1):3349. doi: 10.1038/s41467-018-05559-w. Nat Commun. 2018. PMID: 30135424 Free PMC article.

9

Cyclic GMP-AMP as an Endogenous Second Messenger in Innate Immune Signaling by Cytosolic DNA.

Kato K, Omura H, Ishitani R, Nureki O. Kato K, et al. Annu Rev Biochem. 2017 Jun 20;86:541-566. doi: 10.1146/annurev-biochem-061516-044813. Epub 2017 Apr 7. Annu Rev Biochem. 2017. PMID: 28399655 Review.

10

Cyclic GMP-AMP synthase is activated by double-stranded DNA-induced oligomerization.

Li X, Shu C, Yi G, Chaton CT, Shelton CL, Diao J, Zuo X, Kao CC, Herr AB, Li P. Li X, et al. Immunity. 2013 Dec 12;39(6):1019-31. doi: 10.1016/j.immuni.2013.10.019. Immunity. 2013. PMID: 24332030 Free PMC article.

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