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Toll-like receptors TLR2 and TLR4 block the replication of pancreatic β cells in diet-induced obesity.

Ji Y, Sun S, Shrestha N, Darragh LB, Shirakawa J, Xing Y, He Y, Carboneau BA, Kim H, An D, Ma M, Oberholzer J, Soleimanpour SA, Gannon M, Liu C, Naji A, Kulkarni RN, Wang Y, Kersten S, Qi L.

Nat Immunol. 2019 Jun;20(6):677-686. doi: 10.1038/s41590-019-0396-z. Epub 2019 May 20.


TLR4 is required for the obesity-induced pancreatic beta cell dysfunction.

Li J, Chen L, Zhang Y, Zhang WJ, Xu W, Qin Y, Xu J, Zou D.

Acta Biochim Biophys Sin (Shanghai). 2013 Dec;45(12):1030-8. doi: 10.1093/abbs/gmt092. Epub 2013 Aug 28. Erratum in: Acta Biochim Biophys Sin (Shanghai). 2014 Feb;46(2):167.


Effect of Low-Fat Diet in Obese Mice Lacking Toll-like Receptors.

Rau CS, Wu SC, Lu TH, Wu YC, Wu CJ, Chien PC, Kuo PJ, Lin CW, Tsai CW, Hsieh CH.

Nutrients. 2018 Oct 9;10(10). pii: E1464. doi: 10.3390/nu10101464.


Fetuin A promotes lipotoxicity in β cells through the TLR4 signaling pathway and the role of pioglitazone in anti-lipotoxicity.

Shen X, Yang L, Yan S, Zheng H, Liang L, Cai X, Liao M.

Mol Cell Endocrinol. 2015 Sep 5;412:1-11. doi: 10.1016/j.mce.2015.05.014. Epub 2015 May 15.


Toll-like receptor 2-deficient mice are protected from insulin resistance and beta cell dysfunction induced by a high-fat diet.

Ehses JA, Meier DT, Wueest S, Rytka J, Boller S, Wielinga PY, Schraenen A, Lemaire K, Debray S, Van Lommel L, Pospisilik JA, Tschopp O, Schultze SM, Malipiero U, Esterbauer H, Ellingsgaard H, Rütti S, Schuit FC, Lutz TA, Böni-Schnetzler M, Konrad D, Donath MY.

Diabetologia. 2010 Aug;53(8):1795-806. doi: 10.1007/s00125-010-1747-3. Epub 2010 Apr 21.


TLR2/6 and TLR4-activated macrophages contribute to islet inflammation and impair beta cell insulin gene expression via IL-1 and IL-6.

Nackiewicz D, Dan M, He W, Kim R, Salmi A, Rütti S, Westwell-Roper C, Cunningham A, Speck M, Schuster-Klein C, Guardiola B, Maedler K, Ehses JA.

Diabetologia. 2014 Aug;57(8):1645-54. doi: 10.1007/s00125-014-3249-1. Epub 2014 May 12.


Vitamin K2 can suppress the expression of Toll-like receptor 2 (TLR2) and TLR4, and inhibit calcification of aortic intima in ApoE-/- mice as well as smooth muscle cells.

Wang Z, Wang Z, Zhu J, Long X, Yan J.

Vascular. 2018 Feb;26(1):18-26. doi: 10.1177/1708538117713395. Epub 2017 Jun 6.


Toll-Like Receptor 4 Signaling Pathway Mediates Inhalant Organic Dust-Induced Bone Loss.

Staab E, Thiele GM, Clarey D, Wyatt TA, Romberger DJ, Wells AD, Dusad A, Wang D, Klassen LW, Mikuls TR, Duryee MJ, Poole JA.

PLoS One. 2016 Aug 1;11(8):e0158735. doi: 10.1371/journal.pone.0158735. eCollection 2016.


Toll-like receptor 2 is required for LPS-induced Toll-like receptor 4 signaling and inhibition of ion transport in renal thick ascending limb.

Good DW, George T, Watts BA 3rd.

J Biol Chem. 2012 Jun 8;287(24):20208-20. doi: 10.1074/jbc.M111.336255. Epub 2012 Apr 20.


The role of Toll-like receptor 4 in high-glucose-induced inflammatory and fibrosis markers in human peritoneal mesothelial cells.

Choi SY, Ryu HM, Choi JY, Cho JH, Kim CD, Kim YL, Park SH.

Int Urol Nephrol. 2017 Jan;49(1):171-181. doi: 10.1007/s11255-016-1430-9. Epub 2016 Oct 8.


Toll-like receptor 2/4 heterodimer mediates inflammatory injury in intracerebral hemorrhage.

Wang YC, Zhou Y, Fang H, Lin S, Wang PF, Xiong RP, Chen J, Xiong XY, Lv FL, Liang QL, Yang QW.

Ann Neurol. 2014 Jun;75(6):876-89. doi: 10.1002/ana.24159. Epub 2014 May 28.


Combinatorial interference of toll-like receptor 2 and 4 synergistically stabilizes atherosclerotic plaque in apolipoprotein E-knockout mice.

Yang JM, Wang Y, Qi LH, Wang Y, Gao F, Ding SF, Ni M, Liu CX, Zhang C, Zhang Y.

J Cell Mol Med. 2011 Mar;15(3):602-11. doi: 10.1111/j.1582-4934.2010.01028.x.


PKCζ Is Essential for Pancreatic β-Cell Replication During Insulin Resistance by Regulating mTOR and Cyclin-D2.

Lakshmipathi J, Alvarez-Perez JC, Rosselot C, Casinelli GP, Stamateris RE, Rausell-Palamos F, O'Donnell CP, Vasavada RC, Scott DK, Alonso LC, Garcia-Ocaña A.

Diabetes. 2016 May;65(5):1283-96. doi: 10.2337/db15-1398. Epub 2016 Feb 11.


TLR4-mediated induction of TLR2 signaling is critical in the pathogenesis and resolution of otitis media.

Leichtle A, Hernandez M, Pak K, Yamasaki K, Cheng CF, Webster NJ, Ryan AF, Wasserman SI.

Innate Immun. 2009 Aug;15(4):205-15. doi: 10.1177/1753425909103170. Epub 2009 Jul 8.


Increased expression of toll-like receptor 4 and inflammatory cytokines, interleukin-6 in particular, in islets from a mouse model of obesity and type 2 diabetes.

Ladefoged M, Buschard K, Hansen AM.

APMIS. 2013 Jun;121(6):531-8. doi: 10.1111/apm.12018. Epub 2012 Nov 8.


The critical role of toll-like receptor (TLR) 4 in alcoholic liver disease is independent of the common TLR adapter MyD88.

Hritz I, Mandrekar P, Velayudham A, Catalano D, Dolganiuc A, Kodys K, Kurt-Jones E, Szabo G.

Hepatology. 2008 Oct;48(4):1224-31. doi: 10.1002/hep.22470.


Heat shock protein gp96 interacts with protein phosphatase 5 and controls toll-like receptor 2 (TLR2)-mediated activation of extracellular signal-regulated kinase (ERK) 1/2 in post-hypoxic kidney cells.

Mkaddem SB, Werts C, Goujon JM, Bens M, Pedruzzi E, Ogier-Denis E, Vandewalle A.

J Biol Chem. 2009 May 1;284(18):12541-9. doi: 10.1074/jbc.M808376200. Epub 2009 Mar 5.


HMGB1 signals through toll-like receptor (TLR) 4 and TLR2.

Yu M, Wang H, Ding A, Golenbock DT, Latz E, Czura CJ, Fenton MJ, Tracey KJ, Yang H.

Shock. 2006 Aug;26(2):174-9.


Role of TLR2, TLR4, and MyD88 in murine ozone-induced airway hyperresponsiveness and neutrophilia.

Williams AS, Leung SY, Nath P, Khorasani NM, Bhavsar P, Issa R, Mitchell JA, Adcock IM, Chung KF.

J Appl Physiol (1985). 2007 Oct;103(4):1189-95. Epub 2007 Jul 12.

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