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31110158,32690869,30242092,29555663,29555975,33897882,32341037,30784214,34323404,33985973,29059155,27741508,27707886,31181727,25756511,23801747,27274052,29666302,27185910,29716963,27497761,31221168,27223260,24759320,26792867,27602760,30578319,29686105,32220972,31064850,33792558,31454442,27550197,23859952,30996246,31243151,30224544,33106406,35513563,26876202,28055971,32449815,26152357,29544736,28220803,28591577,31719098,32820253,34672379,27825118,29844167,26093899,35058087,29490263,28811363,25965834,33185682,31901895,26690121,28826721,30128923,30776192,27238081,32917955,25535892,26411689,29966326,30808676,25759396,28036278,30072740,29438990,22456197,33568749,27542219,26435505,34185414,26872377,32525968,27689328,28473535,32522824,24968948,23493267,34335964,26636648,29748904,30513511,26552607,32216207,30773341,28361223,25518339,26573794,33892077,26325261,28252832,24948871,27436429,23851444,28487115,27799360,32294305,25287069,30846826,33357209,23704919,31466944,30962287,33675416,31273254,24374838,28745315,32980775,32199616,32999000,23386686,30918106,30833300,28655783,32234375,33311589,33258506,30649323,32002708,32268276,31969702,31932422,30057199,34230128,25189356,28380417,32565538,28692046,33064355,33692468,24292680,24027426,32931887,32375698,36335093,35226379,34584218,31515456,33121737,34067217,32559345,36429059,23093251,31941606,23443136,29288516,25822367,33578925,34737261,30918020,29089489,33137125,34610962,36258196,23771019,29568923,33115805,34193246,31409897,27667360,33188147,23576568,35993978,32205868,33750894,35503085,25043157,34523032,35052475,34572596,24970477,26814148,24752784,28851861,30077739,35754042,34698359,36793283,28723515,35624341,33909312,34646089,35184651,29858674,32371099,34312180,36229449,32091413,22566699,21170267,33212909,35403746,30871130,25003216,23919967,26474967,32626918,31874108,32220301,22722839,26939004,35966880,31439889,23985008,24379448,28239558,36018068,22767266,23945560,28264478,26885620,30242889,33849067,34697072,32319594,32858191,34145268,32276264,29909985,31604846,34758842,35868070,33682350,34050742,32217447,34045230,33037409,29030409,33039558,37068396,23080125,34815524,36674820,29032717,33414441,24519926,36973255,32485038,34210489,31983247,35867813,35954292,35108506,34490120,34636746,33541283,34475053,24727738,24425228,34946849,24481405,34910907,24935732,33478015,35141012,36284375,35910852,29616091,35766303,34150618,29276153,31471556,31530650,32885168,37095108,35603787,32628318,35617398,23257359,32805234,28723516,24937171,36936148,34716314,34079090,21281786,32446320,31877738,36857796,30314329,35111229,32956765,35349486,31727974,23409183,35014179,27702818,21057494,26390969,35121048,33024699,26495772,29540470,22723089,31685812,33864110,36176749,33110232,36629431,25143959,24737870,35582006,34348348,34235102,31822799,28977932,36787737,29431639,35971022,32275943,35107853,30257982,24114522,29895194,35031262,25152898,35364071,36577036,35954408,36352160,23636849,37084596,24249419,33299560,34229670,35869742,31366581,32681926,36274096,32742924,34889043,32629770,36609444,31748536,30027544,30154147,34439112,28275218,26822877,24448395,35582542,30587810,35105803,34145040,34335030,32332020,32158687,36566018,36035209,23917376,33654218,36779846,34945007,25374905,34439101,35338959,29360794,18427120,34158865,34326322,25670080,33916325,27872477,35455981,33830069,31796516,35800367,35435276,36138018,33476721,33801751,35406510,34680353,35131885,35453603,27444228,31284411,23650019,33135348,29541371,21789088,36497496,32752286,33758595,28077991,32178290,36561929,34067832,35205427,32513899,31143708,31620371,33328650,30157291,31396486,36636695,35871861,34230156,31970232,37151059,29344555,30808987,36010952,29182605,36551505,35740556,36644690,33102047,33813182,34571887,31575828,36969009,33777200,31258834,23618955,32159609,32104754,35207527,31367069,36588949,33552133,35345457,36733715,31454669,37020039,35145276,31936761,34630112,34878263,22295248,32944637,22842706,35587488[uid]

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BRD4 Regulates Metastatic Potential of Castration-Resistant Prostate Cancer through AHNAK.

Shafran JS, Andrieu GP, Györffy B, Denis GV. Shafran JS, et al. Mol Cancer Res. 2019 Aug;17(8):1627-1638. doi: 10.1158/1541-7786.MCR-18-1279. Epub 2019 May 20. Mol Cancer Res. 2019. PMID: 31110158 Free PMC article.

BRD4 regulates key transcription factors that drive epithelial-mesenchymal transition in castration-resistant prostate cancer.

Shafran JS, Jafari N, Casey AN, Győrffy B, Denis GV. Shafran JS, et al. Prostate Cancer Prostatic Dis. 2021 Mar;24(1):268-277. doi: 10.1038/s41391-020-0246-y. Epub 2020 Jul 21. Prostate Cancer Prostatic Dis. 2021. PMID: 32690869 Free PMC article.

Targeting the BRD4-HOXB13 Coregulated Transcriptional Networks with Bromodomain-Kinase Inhibitors to Suppress Metastatic Castration-Resistant Prostate Cancer.

Nerlakanti N, Yao J, Nguyen DT, Patel AK, Eroshkin AM, Lawrence HR, Ayaz M, Kuenzi BM, Agarwal N, Chen Y, Gunawan S, Karim RM, Berndt N, Puskas J, Magliocco AM, Coppola D, Dhillon J, Zhang J, Shymalagovindarajan S, Rix U, Kim Y, Perera R, Lawrence NJ, Schonbrunn E, Mahajan K. Nerlakanti N, et al. Mol Cancer Ther. 2018 Dec;17(12):2796-2810. doi: 10.1158/1535-7163.MCT-18-0602. Epub 2018 Sep 21. Mol Cancer Ther. 2018. PMID: 30242092 Free PMC article.

Targeting Bromodomain and Extra-Terminal (BET) Family Proteins in Castration-Resistant Prostate Cancer (CRPC).

Welti J, Sharp A, Yuan W, Dolling D, Nava Rodrigues D, Figueiredo I, Gil V, Neeb A, Clarke M, Seed G, Crespo M, Sumanasuriya S, Ning J, Knight E, Francis JC, Hughes A, Halsey WS, Paschalis A, Mani RS, Raj GV, Plymate SR, Carreira S, Boysen G, Chinnaiyan AM, Swain A, de Bono JS; International SU2C/PCF Prostate Cancer Dream Team. Welti J, et al. Clin Cancer Res. 2018 Jul 1;24(13):3149-3162. doi: 10.1158/1078-0432.CCR-17-3571. Epub 2018 Mar 19. Clin Cancer Res. 2018. PMID: 29555663

Orphan nuclear receptor TLX contributes to androgen insensitivity in castration-resistant prostate cancer via its repression of androgen receptor transcription.

Jia L, Wu D, Wang Y, You W, Wang Z, Xiao L, Cai G, Xu Z, Zou C, Wang F, Teoh JY, Ng CF, Yu S, Chan FL. Jia L, et al. Oncogene. 2018 Jun;37(25):3340-3355. doi: 10.1038/s41388-018-0198-z. Epub 2018 Mar 20. Oncogene. 2018. PMID: 29555975 Free PMC article.

MYBL2 disrupts the Hippo-YAP pathway and confers castration resistance and metastatic potential in prostate cancer.

Li Q, Wang M, Hu Y, Zhao E, Li J, Ren L, Wang M, Xu Y, Liang Q, Zhang D, Lai Y, Liu S, Peng X, Zhu C, Ye L. Li Q, et al. Theranostics. 2021 Mar 31;11(12):5794-5812. doi: 10.7150/thno.56604. eCollection 2021. Theranostics. 2021. PMID: 33897882 Free PMC article.

Loss of a Negative Feedback Loop between IRF8 and AR Promotes Prostate Cancer Growth and Enzalutamide Resistance.

Wu H, You L, Li Y, Zhao Z, Shi G, Chen Z, Wang Z, Li X, Du S, Ye W, Gao X, Duan J, Cheng Y, Tao W, Bian J, Zhou JR, Zhu Q, Yang Y. Wu H, et al. Cancer Res. 2020 Jul 1;80(13):2927-2939. doi: 10.1158/0008-5472.CAN-19-2549. Epub 2020 Apr 27. Cancer Res. 2020. PMID: 32341037 Free PMC article.

MicroRNA-200a suppresses prostate cancer progression through BRD4/AR signaling pathway.

Guan H, You Z, Wang C, Fang F, Peng R, Mao L, Xu B, Chen M. Guan H, et al. Cancer Med. 2019 Apr;8(4):1474-1485. doi: 10.1002/cam4.2029. Epub 2019 Feb 19. Cancer Med. 2019. PMID: 30784214 Free PMC article.

Histone acetyltransferase 1 upregulates androgen receptor expression to modulate CRPC cell resistance to enzalutamide.

Hong Z, Xiang Z, Zhang P, Wu Q, Xu C, Wang X, Shi G, Hong Z, Wu D. Hong Z, et al. Clin Transl Med. 2021 Jul;11(7):e495. doi: 10.1002/ctm2.495. Clin Transl Med. 2021. PMID: 34323404 Free PMC article.

SLFN5 Regulates LAT1-Mediated mTOR Activation in Castration-Resistant Prostate Cancer.

Martinez RS, Salji MJ, Rushworth L, Ntala C, Rodriguez Blanco G, Hedley A, Clark W, Peixoto P, Hervouet E, Renaude E, Kung SHY, Galbraith LCA, Nixon C, Lilla S, MacKay GM, Fazli L, Gaughan L, Sumpton D, Gleave ME, Zanivan S, Blomme A, Leung HY. Martinez RS, et al. Cancer Res. 2021 Jul 1;81(13):3664-3678. doi: 10.1158/0008-5472.CAN-20-3694. Epub 2021 May 13. Cancer Res. 2021. PMID: 33985973 Free article.

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