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A deficiency in SUMOylation activity disrupts multiple pathways leading to neural tube and heart defects in Xenopus embryos.

Bertke MM, Dubiak KM, Cronin L, Zeng E, Huber PW.

BMC Genomics. 2019 May 17;20(1):386. doi: 10.1186/s12864-019-5773-3.


Ptk7 promotes non-canonical Wnt/PCP-mediated morphogenesis and inhibits Wnt/β-catenin-dependent cell fate decisions during vertebrate development.

Hayes M, Naito M, Daulat A, Angers S, Ciruna B.

Development. 2013 Apr;140(8):1807-18. doi: 10.1242/dev.090183. Erratum in: Development. 2013 Apr;140(8):1807.


Developing Practical Therapeutic Strategies that Target Protein SUMOylation.

Cox OF, Huber PW.

Curr Drug Targets. 2018 Oct 26. doi: 10.2174/1389450119666181026151802. [Epub ahead of print]


Gam1 and the SUMO pathway.

Boggio R, Chiocca S.

Cell Cycle. 2005 Apr;4(4):533-5. Epub 2005 Apr 15. Review.


Novel Mutation of LRP6 Identified in Chinese Han Population Links Canonical WNT Signaling to Neural Tube Defects.

Shi Z, Yang X, Li BB, Chen S, Yang L, Cheng L, Zhang T, Wang H, Zheng Y.

Birth Defects Res. 2018 Jan 15;110(1):63-71. doi: 10.1002/bdr2.1122. Epub 2017 Sep 29.


PTK7 modulates Wnt signaling activity via LRP6.

Bin-Nun N, Lichtig H, Malyarova A, Levy M, Elias S, Frank D.

Development. 2014 Jan;141(2):410-21. doi: 10.1242/dev.095984. Epub 2013 Dec 18.


A mutation in the tuft mouse disrupts TET1 activity and alters the expression of genes that are crucial for neural tube closure.

Fong KS, Hufnagel RB, Khadka VS, Corley MJ, Maunakea AK, Fogelgren B, Ahmed ZM, Lozanoff S.

Dis Model Mech. 2016 May 1;9(5):585-96. doi: 10.1242/dmm.024109. Epub 2016 Mar 17.


Advances in understanding the molecular causes of diabetes-induced birth defects.

Loeken MR.

J Soc Gynecol Investig. 2006 Jan;13(1):2-10. Epub 2005 Nov 21.


The adenovirus protein Gam1 interferes with sumoylation of histone deacetylase 1.

Colombo R, Boggio R, Seiser C, Draetta GF, Chiocca S.

EMBO Rep. 2002 Nov;3(11):1062-8. Epub 2002 Oct 22.


β-catenin regulates Pax3 and Cdx2 for caudal neural tube closure and elongation.

Zhao T, Gan Q, Stokes A, Lassiter RN, Wang Y, Chan J, Han JX, Pleasure DE, Epstein JA, Zhou CJ.

Development. 2014 Jan;141(1):148-57. doi: 10.1242/dev.101550. Epub 2013 Nov 27.


Spatial and temporal aspects of Wnt signaling and planar cell polarity during vertebrate embryonic development.

Sokol SY.

Semin Cell Dev Biol. 2015 Jun;42:78-85. doi: 10.1016/j.semcdb.2015.05.002. Epub 2015 May 15. Review.


Identification of small ubiquitin-like modifier substrates with diverse functions using the Xenopus egg extract system.

Ma L, Aslanian A, Sun H, Jin M, Shi Y, Yates JR 3rd, Hunter T.

Mol Cell Proteomics. 2014 Jul;13(7):1659-75. doi: 10.1074/mcp.M113.035626. Epub 2014 May 5.


Novel mutations in Lrp6 orthologs in mouse and human neural tube defects affect a highly dosage-sensitive Wnt non-canonical planar cell polarity pathway.

Allache R, Lachance S, Guyot MC, De Marco P, Merello E, Justice MJ, Capra V, Kibar Z.

Hum Mol Genet. 2014 Apr 1;23(7):1687-99. doi: 10.1093/hmg/ddt558. Epub 2013 Nov 7. Erratum in: Hum Mol Genet. 2014 Aug 1;23(15):4185.


Diversification of SUMO-activating enzyme in Arabidopsis: implications in SUMO conjugation.

Castaño-Miquel L, Seguí J, Manrique S, Teixeira I, Carretero-Paulet L, Atencio F, Lois LM.

Mol Plant. 2013 Sep;6(5):1646-60. doi: 10.1093/mp/sst049. Epub 2013 Mar 12.


An ATF2-based luciferase reporter to monitor non-canonical Wnt signaling in Xenopus embryos.

Ohkawara B, Niehrs C.

Dev Dyn. 2011 Jan;240(1):188-94. doi: 10.1002/dvdy.22500.


FoxD1 protein interacts with Wnt and BMP signaling to differentially pattern mesoderm and neural tissue.

Polevoy H, Malyarova A, Fonar Y, Elias S, Frank D.

Int J Dev Biol. 2017;61(3-4-5):293-302. doi: 10.1387/ijdb.160300df.


Modulation of nuclear factor-κB signaling and reduction of neural tube defects by quercetin-3-glucoside in embryos of diabetic mice.

Tan C, Meng F, Reece EA, Zhao Z.

Am J Obstet Gynecol. 2018 Aug;219(2):197.e1-197.e8. doi: 10.1016/j.ajog.2018.04.045. Epub 2018 May 5.


Enhanced desumoylation in murine hearts by overexpressed SENP2 leads to congenital heart defects and cardiac dysfunction.

Kim EY, Chen L, Ma Y, Yu W, Chang J, Moskowitz IP, Wang J.

J Mol Cell Cardiol. 2012 Mar;52(3):638-49. doi: 10.1016/j.yjmcc.2011.11.011. Epub 2011 Dec 1.


Expression and in vitro functional analyses of recombinant Gam1 protein.

Avila GA, Ramirez DH, Hildenbrand ZL, Jacquez P, Chiocca S, Sun J, Rosas-Acosta G, Xiao C.

Protein Expr Purif. 2015 Jan;105:47-53. doi: 10.1016/j.pep.2014.10.005. Epub 2014 Oct 16.

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