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TPX2-LIKE PROTEIN 3 is the primary activator of α Aurora kinases and is essential for embryogenesis.

Boruc J, Deng XG, Mylle E, Besbrugge N, Van Durme M, Demidov D, Tomastikova ED, Tan TC, Vandorpe M, Eeckhout D, Beeckman T, Nowack MK, De Jaeger G, Lin H, Liu B, van Damme D.

Plant Physiol. 2019 May 16. pii: pp.01515.2018. doi: 10.1104/pp.18.01515. [Epub ahead of print]


A novel mechanism for activation of the protein kinase Aurora A.

Eyers PA, Erikson E, Chen LG, Maller JL.

Curr Biol. 2003 Apr 15;13(8):691-7.


Urochordate ascidians possess a single isoform of Aurora kinase that localizes to the midbody via TPX2 in eggs and cleavage stage embryos.

Hebras C, McDougall A.

PLoS One. 2012;7(9):e45431. doi: 10.1371/journal.pone.0045431. Epub 2012 Sep 20.


Ran modulates spindle assembly by regulating a subset of TPX2 and Kid activities including Aurora A activation.

Trieselmann N, Armstrong S, Rauw J, Wilde A.

J Cell Sci. 2003 Dec 1;116(Pt 23):4791-8.


Human TPX2 is required for targeting Aurora-A kinase to the spindle.

Kufer TA, Silljé HH, Körner R, Gruss OJ, Meraldi P, Nigg EA.

J Cell Biol. 2002 Aug 19;158(4):617-23. Epub 2002 Aug 12.


Control of Aurora-A stability through interaction with TPX2.

Giubettini M, Asteriti IA, Scrofani J, De Luca M, Lindon C, Lavia P, Guarguaglini G.

J Cell Sci. 2011 Jan 1;124(Pt 1):113-22. doi: 10.1242/jcs.075457. Epub 2010 Dec 8.


Phosphorylation of MAP65-1 by Arabidopsis Aurora Kinases Is Required for Efficient Cell Cycle Progression.

Boruc J, Weimer AK, Stoppin-Mellet V, Mylle E, Kosetsu K, Cedeño C, Jaquinod M, Njo M, De Milde L, Tompa P, Gonzalez N, Inzé D, Beeckman T, Vantard M, Van Damme D.

Plant Physiol. 2017 Jan;173(1):582-599. doi: 10.1104/pp.16.01602. Epub 2016 Nov 22.


An essential function of the C. elegans ortholog of TPX2 is to localize activated aurora A kinase to mitotic spindles.

Ozlü N, Srayko M, Kinoshita K, Habermann B, O'toole ET, Müller-Reichert T, Schmalz N, Desai A, Hyman AA.

Dev Cell. 2005 Aug;9(2):237-48.


Characterization of the TPX2 domains involved in microtubule nucleation and spindle assembly in Xenopus egg extracts.

Brunet S, Sardon T, Zimmerman T, Wittmann T, Pepperkok R, Karsenti E, Vernos I.

Mol Biol Cell. 2004 Dec;15(12):5318-28. Epub 2004 Sep 22.


Arabidopsis α Aurora kinases function in formative cell division plane orientation.

Van Damme D, De Rybel B, Gudesblat G, Demidov D, Grunewald W, De Smet I, Houben A, Beeckman T, Russinova E.

Plant Cell. 2011 Nov;23(11):4013-24. doi: 10.1105/tpc.111.089565. Epub 2011 Nov 1.


A novel role for TPX2 as a scaffold and co-activator protein of the Chromosomal Passenger Complex.

Iyer J, Tsai MY.

Cell Signal. 2012 Aug;24(8):1677-89. doi: 10.1016/j.cellsig.2012.04.014. Epub 2012 Apr 25.


Spindle pole regulation by a discrete Eg5-interacting domain in TPX2.

Eckerdt F, Eyers PA, Lewellyn AL, Prigent C, Maller JL.

Curr Biol. 2008 Apr 8;18(7):519-25. doi: 10.1016/j.cub.2008.02.077. Epub 2008 Mar 27.


Protein phosphatase 6 regulates mitotic spindle formation by controlling the T-loop phosphorylation state of Aurora A bound to its activator TPX2.

Zeng K, Bastos RN, Barr FA, Gruneberg U.

J Cell Biol. 2010 Dec 27;191(7):1315-32. doi: 10.1083/jcb.201008106.


Characterization of Three Druggable Hot-Spots in the Aurora-A/TPX2 Interaction Using Biochemical, Biophysical, and Fragment-Based Approaches.

McIntyre PJ, Collins PM, Vrzal L, Birchall K, Arnold LH, Mpamhanga C, Coombs PJ, Burgess SG, Richards MW, Winter A, Veverka V, Delft FV, Merritt A, Bayliss R.

ACS Chem Biol. 2017 Nov 17;12(11):2906-2914. doi: 10.1021/acschembio.7b00537. Epub 2017 Oct 30.


Regulation of Xenopus Aurora A activation by TPX2.

Eyers PA, Maller JL.

J Biol Chem. 2004 Mar 5;279(10):9008-15. Epub 2003 Dec 29.


Overexpressed TPX2 causes ectopic formation of microtubular arrays in the nuclei of acentrosomal plant cells.

Petrovská B, Jerábková H, Kohoutová L, Cenklová V, Pochylová Ž, Gelová Z, Kocárová G, Váchová L, Kurejová M, Tomastíková E, Binarová P.

J Exp Bot. 2013 Nov;64(14):4575-87. doi: 10.1093/jxb/ert271. Epub 2013 Sep 4.


The α-Aurora Kinases Function in Vascular Development in Arabidopsis.

Lee KH, Utku A, Qi L, Wang H.

Plant Cell Physiol. 2019 Jan 1;60(1):188-201. doi: 10.1093/pcp/pcy195.


Phosphorylation of targeting protein for Xenopus kinesin-like protein 2 (TPX2) at threonine 72 in spindle assembly.

Shim SY, Perez de Castro I, Neumayer G, Wang J, Park SK, Sanada K, Nguyen MD.

J Biol Chem. 2015 Apr 3;290(14):9122-34. doi: 10.1074/jbc.M114.591545. Epub 2015 Feb 16.


Determinants for Aurora-A activation and Aurora-B discrimination by TPX2.

Bayliss R, Sardon T, Ebert J, Lindner D, Vernos I, Conti E.

Cell Cycle. 2004 Apr;3(4):404-7. Epub 2004 Apr 1.


Identification of a TPX2-like microtubule-associated protein in Drosophila.

Goshima G.

PLoS One. 2011;6(11):e28120. doi: 10.1371/journal.pone.0028120. Epub 2011 Nov 30.

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