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Items: 1 to 20 of 98

1.

Tau accumulation triggers STAT1-dependent memory deficits by suppressing NMDA receptor expression.

Li XG, Hong XY, Wang YL, Zhang SJ, Zhang JF, Li XC, Liu YC, Sun DS, Feng Q, Ye JW, Gao Y, Ke D, Wang Q, Li HL, Ye K, Liu GP, Wang JZ.

EMBO Rep. 2019 Jun;20(6). pii: e47202. doi: 10.15252/embr.201847202. Epub 2019 May 13.

PMID:
31085626
2.

Tau accumulation induces synaptic impairment and memory deficit by calcineurin-mediated inactivation of nuclear CaMKIV/CREB signaling.

Yin Y, Gao D, Wang Y, Wang ZH, Wang X, Ye J, Wu D, Fang L, Pi G, Yang Y, Wang XC, Lu C, Ye K, Wang JZ.

Proc Natl Acad Sci U S A. 2016 Jun 28;113(26):E3773-81. doi: 10.1073/pnas.1604519113. Epub 2016 Jun 13.

3.

Age-dependent impairment of cognitive and synaptic function in the htau mouse model of tau pathology.

Polydoro M, Acker CM, Duff K, Castillo PE, Davies P.

J Neurosci. 2009 Aug 26;29(34):10741-9. doi: 10.1523/JNEUROSCI.1065-09.2009.

4.

NMDA receptor subunit composition determines beta-amyloid-induced neurodegeneration and synaptic loss.

Tackenberg C, Grinschgl S, Trutzel A, Santuccione AC, Frey MC, Konietzko U, Grimm J, Brandt R, Nitsch RM.

Cell Death Dis. 2013 Apr 25;4:e608. doi: 10.1038/cddis.2013.129.

5.

Mechanism of Oxidative Stress and Synapse Dysfunction in the Pathogenesis of Alzheimer's Disease: Understanding the Therapeutics Strategies.

Kamat PK, Kalani A, Rai S, Swarnkar S, Tota S, Nath C, Tyagi N.

Mol Neurobiol. 2016 Jan;53(1):648-661. doi: 10.1007/s12035-014-9053-6. Epub 2014 Dec 17. Review.

6.

Tau accumulation impairs mitophagy via increasing mitochondrial membrane potential and reducing mitochondrial Parkin.

Hu Y, Li XC, Wang ZH, Luo Y, Zhang X, Liu XP, Feng Q, Wang Q, Yue Z, Chen Z, Ye K, Wang JZ, Liu GP.

Oncotarget. 2016 Apr 5;7(14):17356-68. doi: 10.18632/oncotarget.7861.

7.

Downregulating ANP32A rescues synapse and memory loss via chromatin remodeling in Alzheimer model.

Chai GS, Feng Q, Wang ZH, Hu Y, Sun DS, Li XG, Ke D, Li HL, Liu GP, Wang JZ.

Mol Neurodegener. 2017 May 4;12(1):34. doi: 10.1186/s13024-017-0178-8.

8.

Polymeric alkylpyridinium salts permit intracellular delivery of human Tau in rat hippocampal neurons: requirement of Tau phosphorylation for functional deficits.

Koss DJ, Robinson L, Mietelska-Porowska A, Gasiorowska A, Sepčić K, Turk T, Jaspars M, Niewiadomska G, Scott RH, Platt B, Riedel G.

Cell Mol Life Sci. 2015 Dec;72(23):4613-32. doi: 10.1007/s00018-015-1949-4. Epub 2015 Jun 13.

PMID:
26070304
9.

GluN2B-containing NMDA receptors contribute to the beneficial effects of hydrogen sulfide on cognitive and synaptic plasticity deficits in APP/PS1 transgenic mice.

Yang YJ, Zhao Y, Yu B, Xu GG, Wang W, Zhan JQ, Tang ZY, Wang T, Wei B.

Neuroscience. 2016 Oct 29;335:170-83. doi: 10.1016/j.neuroscience.2016.08.033. Epub 2016 Aug 28.

PMID:
27581687
10.

Early depletion of CA1 neurons and late neurodegeneration in a mouse tauopathy model.

Helboe L, Egebjerg J, Barkholt P, Volbracht C.

Brain Res. 2017 Jun 15;1665:22-35. doi: 10.1016/j.brainres.2017.04.002. Epub 2017 Apr 11.

PMID:
28411086
11.

Pharmacogenetic neuronal stimulation increases human tau pathology and trans-synaptic spread of tau to distal brain regions in mice.

Schultz MK Jr, Gentzel R, Usenovic M, Gretzula C, Ware C, Parmentier-Batteur S, Schachter JB, Zariwala HA.

Neurobiol Dis. 2018 Oct;118:161-176. doi: 10.1016/j.nbd.2018.07.003. Epub 2018 Jul 7.

PMID:
30049665
12.

Hippocampal NMDA receptors and the previous experience effect on memory.

Cercato MC, Colettis N, Snitcofsky M, Aguirre AI, Kornisiuk EE, Baez MV, Jerusalinsky DA.

J Physiol Paris. 2014 Sep-Dec;108(4-6):263-9. doi: 10.1016/j.jphysparis.2014.08.001. Epub 2014 Aug 15. Review.

PMID:
25132342
13.

A novel transgenic mouse expressing double mutant tau driven by its natural promoter exhibits tauopathy characteristics.

Rosenmann H, Grigoriadis N, Eldar-Levy H, Avital A, Rozenstein L, Touloumi O, Behar L, Ben-Hur T, Avraham Y, Berry E, Segal M, Ginzburg I, Abramsky O.

Exp Neurol. 2008 Jul;212(1):71-84. doi: 10.1016/j.expneurol.2008.03.007. Epub 2008 Mar 21.

PMID:
18490011
14.

Extrasynaptic NMDA receptor-induced tau overexpression mediates neuronal death through suppressing survival signaling ERK phosphorylation.

Sun XY, Tuo QZ, Liuyang ZY, Xie AJ, Feng XL, Yan X, Qiu M, Li S, Wang XL, Cao FY, Wang XC, Wang JZ, Liu R.

Cell Death Dis. 2016 Nov 3;7(11):e2449. doi: 10.1038/cddis.2016.329.

15.

Human wild-type full-length tau accumulation disrupts mitochondrial dynamics and the functions via increasing mitofusins.

Li XC, Hu Y, Wang ZH, Luo Y, Zhang Y, Liu XP, Feng Q, Wang Q, Ye K, Liu GP, Wang JZ.

Sci Rep. 2016 Apr 21;6:24756. doi: 10.1038/srep24756.

16.

STAT1 negatively regulates spatial memory formation and mediates the memory-impairing effect of Aβ.

Hsu WL, Ma YL, Hsieh DY, Liu YC, Lee EH.

Neuropsychopharmacology. 2014 Feb;39(3):746-58. doi: 10.1038/npp.2013.263. Epub 2013 Sep 30.

17.

Accumulation of human full-length tau induces degradation of nicotinic acetylcholine receptor α4 via activating calpain-2.

Yin Y, Wang Y, Gao D, Ye J, Wang X, Fang L, Wu D, Pi G, Lu C, Zhou XW, Yang Y, Wang JZ.

Sci Rep. 2016 Jun 9;6:27283. doi: 10.1038/srep27283.

18.

A Rare Variant Identified Within the GluN2B C-Terminus in a Patient with Autism Affects NMDA Receptor Surface Expression and Spine Density.

Liu S, Zhou L, Yuan H, Vieira M, Sanz-Clemente A, Badger JD 2nd, Lu W, Traynelis SF, Roche KW.

J Neurosci. 2017 Apr 12;37(15):4093-4102. doi: 10.1523/JNEUROSCI.0827-16.2017. Epub 2017 Mar 10.

19.

Expression of P301L-hTau in mouse MEC induces hippocampus-dependent memory deficit.

Liu X, Zeng K, Li M, Wang Q, Liu R, Zhang B, Wang JZ, Shu X, Wang X.

Sci Rep. 2017 Jun 20;7(1):3914. doi: 10.1038/s41598-017-04305-4.

20.

Modulating the Balance of Synaptic and Extrasynaptic NMDA Receptors Shows Positive Effects against Amyloid-β-Induced Neurotoxicity.

Huang Y, Shen W, Su J, Cheng B, Li D, Liu G, Zhou WX, Zhang YX.

J Alzheimers Dis. 2017;57(3):885-897. doi: 10.3233/JAD-161186.

PMID:
28269783

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