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Items: 1 to 20 of 95

1.

Gli signaling pathway modulates fibroblast activation and facilitates scar formation in pulmonary fibrosis.

Tsukui T, Ueha S, Shichino S, Hashimoto S, Nakajima T, Shiraishi K, Kihara M, Kiyonari H, Inagaki Y, Matsushima K.

Biochem Biophys Res Commun. 2019 Jun 30;514(3):684-690. doi: 10.1016/j.bbrc.2019.05.011. Epub 2019 May 8.

PMID:
31078262
2.

Targeting the hedgehog-glioma-associated oncogene homolog pathway inhibits bleomycin-induced lung fibrosis in mice.

Moshai EF, Wémeau-Stervinou L, Cigna N, Brayer S, Sommé JM, Crestani B, Mailleux AA.

Am J Respir Cell Mol Biol. 2014 Jul;51(1):11-25. doi: 10.1165/rcmb.2013-0154OC.

PMID:
24450438
3.

Intratracheal cell transfer demonstrates the profibrotic potential of resident fibroblasts in pulmonary fibrosis.

Tsukui T, Ueha S, Shichino S, Inagaki Y, Matsushima K.

Am J Pathol. 2015 Nov;185(11):2939-48. doi: 10.1016/j.ajpath.2015.07.022. Epub 2015 Oct 9.

PMID:
26456579
4.

Induction of Connective Tissue Growth Factor Expression by Hypoxia in Human Lung Fibroblasts via the MEKK1/MEK1/ERK1/GLI-1/GLI-2 and AP-1 Pathways.

Cheng Y, Lin CH, Chen JY, Li CH, Liu YT, Chen BC.

PLoS One. 2016 Aug 3;11(8):e0160593. doi: 10.1371/journal.pone.0160593. eCollection 2016. Erratum in: PLoS One. 2017 Nov 21;12 (11):e0188608.

5.

Activated alveolar epithelial cells initiate fibrosis through autocrine and paracrine secretion of connective tissue growth factor.

Yang J, Velikoff M, Canalis E, Horowitz JC, Kim KK.

Am J Physiol Lung Cell Mol Physiol. 2014 Apr 15;306(8):L786-96. doi: 10.1152/ajplung.00243.2013. Epub 2014 Feb 7.

6.

Galectin-1 inhibition attenuates profibrotic signaling in hypoxia-induced pulmonary fibrosis.

Kathiriya JJ, Nakra N, Nixon J, Patel PS, Vaghasiya V, Alhassani A, Tian Z, Allen-Gipson D, Davé V.

Cell Death Discov. 2017 Apr 10;3:17010. doi: 10.1038/cddiscovery.2017.10. eCollection 2017.

7.

Sunitinib, a Small-Molecule Kinase Inhibitor, Attenuates Bleomycin-Induced Pulmonary Fibrosis in Mice.

Huang X, Wang W, Yuan H, Sun J, Li L, Wu X, Luo J, Gu Y.

Tohoku J Exp Med. 2016 Aug;239(4):251-61. doi: 10.1620/tjem.239.251.

8.

Inhibition of Wnt/β-catenin signaling suppresses bleomycin-induced pulmonary fibrosis by attenuating the expression of TGF-β1 and FGF-2.

Chen X, Shi C, Meng X, Zhang K, Li X, Wang C, Xiang Z, Hu K, Han X.

Exp Mol Pathol. 2016 Aug;101(1):22-30. doi: 10.1016/j.yexmp.2016.04.003. Epub 2016 Apr 23.

9.

Pivotal role of connective tissue growth factor in lung fibrosis: MAPK-dependent transcriptional activation of type I collagen.

Ponticos M, Holmes AM, Shi-wen X, Leoni P, Khan K, Rajkumar VS, Hoyles RK, Bou-Gharios G, Black CM, Denton CP, Abraham DJ, Leask A, Lindahl GE.

Arthritis Rheum. 2009 Jul;60(7):2142-55. doi: 10.1002/art.24620.

10.

Follistatin-Like 1 Promotes Bleomycin-Induced Pulmonary Fibrosis through the Transforming Growth Factor Beta 1/Mitogen-Activated Protein Kinase Signaling Pathway.

Jin YK, Li XH, Wang W, Liu J, Zhang W, Fang YS, Zhang ZF, Dai HP, Ning W, Wang C.

Chin Med J (Engl). 2018 Aug 20;131(16):1917-1925. doi: 10.4103/0366-6999.238151.

11.

The transcription factor GLI2 as a downstream mediator of transforming growth factor-β-induced fibroblast activation in SSc.

Liang R, Šumová B, Cordazzo C, Mallano T, Zhang Y, Wohlfahrt T, Dees C, Ramming A, Krasowska D, Michalska-Jakubus M, Distler O, Schett G, Šenolt L, Distler JH.

Ann Rheum Dis. 2017 Apr;76(4):756-764. doi: 10.1136/annrheumdis-2016-209698. Epub 2016 Oct 28.

PMID:
27793816
12.

Qualitative rather than quantitative changes are hallmarks of fibroblasts in bleomycin-induced pulmonary fibrosis.

Tsukui T, Ueha S, Abe J, Hashimoto S, Shichino S, Shimaoka T, Shand FH, Arakawa Y, Oshima K, Hattori M, Inagaki Y, Tomura M, Matsushima K.

Am J Pathol. 2013 Sep;183(3):758-73. doi: 10.1016/j.ajpath.2013.06.005. Epub 2013 Jul 22.

PMID:
23886891
13.

Pulmonary fibrosis requires cell-autonomous mesenchymal fibroblast growth factor (FGF) signaling.

Guzy RD, Li L, Smith C, Dorry SJ, Koo HY, Chen L, Ornitz DM.

J Biol Chem. 2017 Jun 23;292(25):10364-10378. doi: 10.1074/jbc.M117.791764. Epub 2017 May 9.

14.

Hypoxia-preconditioned mesenchymal stem cells attenuate bleomycin-induced pulmonary fibrosis.

Lan YW, Choo KB, Chen CM, Hung TH, Chen YB, Hsieh CH, Kuo HP, Chong KY.

Stem Cell Res Ther. 2015 May 20;6:97. doi: 10.1186/s13287-015-0081-6.

15.

Protein tyrosine phosphatase α mediates profibrotic signaling in lung fibroblasts through TGF-β responsiveness.

Aschner Y, Khalifah AP, Briones N, Yamashita C, Dolgonos L, Young SK, Campbell MN, Riches DW, Redente EF, Janssen WJ, Henson PM, Sap J, Vacaresse N, Kapus A, McCulloch CA, Zemans RL, Downey GP.

Am J Pathol. 2014 May;184(5):1489-502. doi: 10.1016/j.ajpath.2014.01.016. Epub 2014 Mar 17.

16.

TGFβ signaling in lung epithelium regulates bleomycin-induced alveolar injury and fibroblast recruitment.

Degryse AL, Tanjore H, Xu XC, Polosukhin VV, Jones BR, Boomershine CS, Ortiz C, Sherrill TP, McMahon FB, Gleaves LA, Blackwell TS, Lawson WE.

Am J Physiol Lung Cell Mol Physiol. 2011 Jun;300(6):L887-97. doi: 10.1152/ajplung.00397.2010. Epub 2011 Mar 25.

17.

Mitogen-activated Protein Kinase-activated Protein Kinase 2 Inhibition Attenuates Fibroblast Invasion and Severe Lung Fibrosis.

Liang J, Liu N, Liu X, Mena JM, Xie T, Geng Y, Huan C, Zhang Y, Taghavifar F, Huang G, Kurkciyan A, Barron V, Jiang D, Noble PW.

Am J Respir Cell Mol Biol. 2019 Jan;60(1):41-48. doi: 10.1165/rcmb.2018-0033OC.

PMID:
30130411
18.

MicroRNA-101 attenuates pulmonary fibrosis by inhibiting fibroblast proliferation and activation.

Huang C, Xiao X, Yang Y, Mishra A, Liang Y, Zeng X, Yang X, Xu D, Blackburn MR, Henke CA, Liu L.

J Biol Chem. 2017 Oct 6;292(40):16420-16439. doi: 10.1074/jbc.M117.805747. Epub 2017 Jul 18. Erratum in: J Biol Chem. 2019 Apr 26;294(17):6694.

19.

Fibroblast Activation Protein (FAP) Accelerates Collagen Degradation and Clearance from Lungs in Mice.

Fan MH, Zhu Q, Li HH, Ra HJ, Majumdar S, Gulick DL, Jerome JA, Madsen DH, Christofidou-Solomidou M, Speicher DW, Bachovchin WW, Feghali-Bostwick C, Puré E.

J Biol Chem. 2016 Apr 8;291(15):8070-89. doi: 10.1074/jbc.M115.701433. Epub 2015 Dec 9.

20.

Cell-specific expression of runt-related transcription factor 2 contributes to pulmonary fibrosis.

Mümmler C, Burgy O, Hermann S, Mutze K, Günther A, Königshoff M.

FASEB J. 2018 Feb;32(2):703-716. doi: 10.1096/fj.201700482R. Epub 2018 Jan 4.

PMID:
28986417

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