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B-vitamins and body composition: integrating observational and experimental evidence from the B-PROOF study.

Oliai Araghi S, Braun KVE, van der Velde N, van Dijk SC, van Schoor NM, Zillikens MC, de Groot LCPGM, Uitterlinden AG, Stricker BH, Voortman T, Kiefte-de Jong JC.

Eur J Nutr. 2019 May 10. doi: 10.1007/s00394-019-01985-8. [Epub ahead of print]


Folate and Vitamin B12-Related Biomarkers in Relation to Brain Volumes.

van der Zwaluw NL, Brouwer-Brolsma EM, van de Rest O, van Wijngaarden JP, In 't Veld PH, Kourie DI, Swart KM, Enneman AW, van Dijk SC, van der Velde N, Kessels RP, Smeets PA, Kok FJ, Dhonukshe-Rutten RA, de Groot LC.

Nutrients. 2016 Dec 24;9(1). pii: E8. doi: 10.3390/nu9010008.


Folic acid with or without vitamin B12 for cognition and dementia.

Malouf M, Grimley EJ, Areosa SA.

Cochrane Database Syst Rev. 2003;(4):CD004514. Review. Update in: Cochrane Database Syst Rev. 2008;(4):CD004514.


B-Vitamin Therapy for Kidney Transplant Recipients Lowers Homocysteine and Improves Selective Cognitive Outcomes in the Randomized FAVORIT Ancillary Cognitive Trial.

Scott TM, Rogers G, Weiner DE, Livingston K, Selhub J, Jacques PF, Rosenberg IH, Troen AM.

J Prev Alzheimers Dis. 2017;4(3):174-182. doi: 10.14283/jpad.2017.15.


Interactions between plasma concentrations of folate and markers of vitamin B(12) status with cognitive performance in elderly people not exposed to folic acid fortification: the Hordaland Health Study.

Doets EL, Ueland PM, Tell GS, Vollset SE, Nygård OK, Van't Veer P, de Groot LC, Nurk E, Refsum H, Smith AD, Eussen SJ.

Br J Nutr. 2014 Mar 28;111(6):1085-95. doi: 10.1017/S000711451300336X. Epub 2013 Nov 11.


Functional vitamin B12 deficiency and determination of holotranscobalamin in populations at risk.

Herrmann W, Obeid R, Schorr H, Geisel J.

Clin Chem Lab Med. 2003 Nov;41(11):1478-88.


Vitamin B12 Intake and Related Biomarkers: Associations in a Dutch Elderly Population.

van Wijngaarden JP, Dhonukshe-Rutten RAM, Brouwer-Brolsma EM, Enneman AW, Swart KMA, van Dijk SC, In 't Veld PH, van Schoor NM, van der Velde N, de Jonge R, Lips P, Uitterlinden AG, de Groot LCPGM.

J Nutr Health Aging. 2017;21(10):1268-1276. doi: 10.1007/s12603-017-0911-6.


Rationale and design of the B-PROOF study, a randomized controlled trial on the effect of supplemental intake of vitamin B12 and folic acid on fracture incidence.

van Wijngaarden JP, Dhonukshe-Rutten RA, van Schoor NM, van der Velde N, Swart KM, Enneman AW, van Dijk SC, Brouwer-Brolsma EM, Zillikens MC, van Meurs JB, Brug J, Uitterlinden AG, Lips P, de Groot LC.

BMC Geriatr. 2011 Dec 2;11:80. doi: 10.1186/1471-2318-11-80.


Vitamin B12 and folate levels in healthy Swiss senior citizens: a prospective study evaluating reference intervals and decision limits.

Risch M, Meier DW, Sakem B, Medina Escobar P, Risch C, Nydegger U, Risch L.

BMC Geriatr. 2015 Jul 11;15:82. doi: 10.1186/s12877-015-0060-x.


Folic acid with or without vitamin B12 for the prevention and treatment of healthy elderly and demented people.

Malouf R, Grimley Evans J.

Cochrane Database Syst Rev. 2008 Oct 8;(4):CD004514. doi: 10.1002/14651858.CD004514.pub2. Review.


B-vitamins and homocysteine in Spanish institutionalized elderly.

Gonzalez-Gross M, Sola R, Albers U, Barrios L, Alder M, Castillo MJ, Pietrzik K.

Int J Vitam Nutr Res. 2007 Jan;77(1):22-33.


[Associations between insulin resistance and three B-vitamins in European adolescents: the HELENA study].

Iglesia I, González-Gross M, Huybrechts I, De Miguel-Etayo P, Molnar D, Manios Y, Widhalm K, Gottrand F, Kafatos A, Marcos A, De la O Puerta A, Leclercq C, De Henauw S, Stehle P, Kersting M, Mouratidou T, Moreno LA.

Nutr Hosp. 2017 Jun 5;34(3):568-577. doi: 10.20960/nh.559.


Vitamin B2, vitamin B12 and total homocysteine status in children and their associations with dietary intake of B-vitamins from different food groups: the Healthy Growth Study.

Manios Y, Moschonis G, Dekkers R, Mavrogianni C, Grammatikaki E, van den Heuvel E.

Eur J Nutr. 2017 Feb;56(1):321-331. doi: 10.1007/s00394-015-1082-z. Epub 2015 Oct 29.


The effects of long-term daily folic acid and vitamin B12 supplementation on genome-wide DNA methylation in elderly subjects.

Kok DE, Dhonukshe-Rutten RA, Lute C, Heil SG, Uitterlinden AG, van der Velde N, van Meurs JB, van Schoor NM, Hooiveld GJ, de Groot LC, Kampman E, Steegenga WT.

Clin Epigenetics. 2015 Nov 14;7:121. doi: 10.1186/s13148-015-0154-5. eCollection 2015.


[Serum homocysteine, folate and vitamin B12 in venezuelan elderly].

Meertens L, Díaz N, Solano L, Baron MA, Rodríguez A.

Arch Latinoam Nutr. 2007 Mar;57(1):26-32. Spanish.


Dietary Intakes of Folic Acid and Methionine in Early Childhood Are Associated with Body Composition at School Age.

Braun KV, Voortman T, Kiefte-de Jong JC, Jaddoe VW, Hofman A, Franco OH, van den Hooven EH.

J Nutr. 2015 Sep;145(9):2123-9. doi: 10.3945/jn.115.216283. Epub 2015 Jul 22.


Folic Acid and Vitamin B12 Supplementation and the Risk of Cancer: Long-term Follow-up of the B Vitamins for the Prevention of Osteoporotic Fractures (B-PROOF) Trial.

Oliai Araghi S, Kiefte-de Jong JC, van Dijk SC, Swart KMA, van Laarhoven HW, van Schoor NM, de Groot LCPGM, Lemmens V, Stricker BH, Uitterlinden AG, van der Velde N.

Cancer Epidemiol Biomarkers Prev. 2019 Feb;28(2):275-282. doi: 10.1158/1055-9965.EPI-17-1198. Epub 2018 Oct 19.


Effect of Vitamin B12 and Folic Acid Supplementation on Bone Mineral Density and Quantitative Ultrasound Parameters in Older People with an Elevated Plasma Homocysteine Level: B-PROOF, a Randomized Controlled Trial.

Enneman AW, Swart KM, van Wijngaarden JP, van Dijk SC, Ham AC, Brouwer-Brolsma EM, van der Zwaluw NL, Dhonukshe-Rutten RA, van der Cammen TJ, de Groot LC, van Meurs J, Lips P, Uitterlinden AG, Zillikens MC, van Schoor NM, van der Velde N.

Calcif Tissue Int. 2015 May;96(5):401-9. doi: 10.1007/s00223-015-9968-6. Epub 2015 Feb 25.

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