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Improved quantitative assessment of HBV-associated liver fibrosis using second-harmonic generation microscopy with feature selection.

Hsiao CY, Teng X, Su TH, Lee PH, Kao JH, Huang KW.

Clin Res Hepatol Gastroenterol. 2019 May 7. pii: S2210-7401(19)30093-2. doi: 10.1016/j.clinre.2019.04.003. [Epub ahead of print]


Fibrillar collagen scoring by second harmonic microscopy: a new tool in the assessment of liver fibrosis.

Gailhouste L, Le Grand Y, Odin C, Guyader D, Turlin B, Ezan F, Désille Y, Guilbert T, Bessard A, Frémin C, Theret N, Baffet G.

J Hepatol. 2010 Mar;52(3):398-406. doi: 10.1016/j.jhep.2009.12.009. Epub 2010 Jan 17.


Automated biphasic morphological assessment of hepatitis B-related liver fibrosis using second harmonic generation microscopy.

Wang TH, Chen TC, Teng X, Liang KH, Yeh CT.

Sci Rep. 2015 Aug 11;5:12962. doi: 10.1038/srep12962.


Second harmonic generation microscopy provides accurate automated staging of liver fibrosis in patients with non-alcoholic fatty liver disease.

Chang PE, Goh GBB, Leow WQ, Shen L, Lim KH, Tan CK.

PLoS One. 2018 Jun 20;13(6):e0199166. doi: 10.1371/journal.pone.0199166. eCollection 2018.


Nonlinear optical microscopy: use of second harmonic generation and two-photon microscopy for automated quantitative liver fibrosis studies.

Sun W, Chang S, Tai DC, Tan N, Xiao G, Tang H, Yu H.

J Biomed Opt. 2008 Nov-Dec;13(6):064010. doi: 10.1117/1.3041159.


Automated evaluation of liver fibrosis in thioacetamide, carbon tetrachloride, and bile duct ligation rodent models using second-harmonic generation/two-photon excited fluorescence microscopy.

Liu F, Chen L, Rao HY, Teng X, Ren YY, Lu YQ, Zhang W, Wu N, Liu FF, Wei L.

Lab Invest. 2017 Jan;97(1):84-92. doi: 10.1038/labinvest.2016.128. Epub 2016 Dec 5.


qFibrosis: a fully-quantitative innovative method incorporating histological features to facilitate accurate fibrosis scoring in animal model and chronic hepatitis B patients.

Xu S, Wang Y, Tai DCS, Wang S, Cheng CL, Peng Q, Yan J, Chen Y, Sun J, Liang X, Zhu Y, Rajapakse JC, Welsch RE, So PTC, Wee A, Hou J, Yu H.

J Hepatol. 2014 Aug;61(2):260-269. doi: 10.1016/j.jhep.2014.02.015. Epub 2014 Feb 26.


Quantification of hepatic steatosis in chronic liver disease using novel automated method of second harmonic generation and two-photon excited fluorescence.

Goh GB, Leow WQ, Liang S, Wan WK, Lim TKH, Tan CK, Chang PE.

Sci Rep. 2019 Feb 27;9(1):2975. doi: 10.1038/s41598-019-39783-1.


Quantification of liver fibrosis via second harmonic imaging of the Glisson's capsule from liver surface.

Xu S, Kang CH, Gou X, Peng Q, Yan J, Zhuo S, Cheng CL, He Y, Kang Y, Xia W, So PT, Welsch R, Rajapakse JC, Yu H.

J Biophotonics. 2016 Apr;9(4):351-63. doi: 10.1002/jbio.201500001. Epub 2015 Jul 1.


Fibro-C-Index: comprehensive, morphology-based quantification of liver fibrosis using second harmonic generation and two-photon microscopy.

Tai DC, Tan N, Xu S, Kang CH, Chia SM, Cheng CL, Wee A, Wei CL, Raja AM, Xiao G, Chang S, Rajapakse JC, So PT, Tang HH, Chen CS, Yu H.

J Biomed Opt. 2009 Jul-Aug;14(4):044013. doi: 10.1117/1.3183811.


Second Harmonic Generation Reveals Subtle Fibrosis Differences in Adult and Pediatric Nonalcoholic Fatty Liver Disease.

Liu F, Zhao JM, Rao HY, Yu WM, Zhang W, Theise ND, Wee A, Wei L.

Am J Clin Pathol. 2017 Nov 20;148(6):502-512. doi: 10.1093/ajcp/aqx104.


Evaluation of area-based collagen scoring by nonlinear microscopy in chronic hepatitis C-induced liver fibrosis.

Sevrain D, Dubreuil M, Dolman GE, Zaitoun A, Irving W, Guha IN, Odin C, Le Grand Y.

Biomed Opt Express. 2015 Mar 11;6(4):1209-18. doi: 10.1364/BOE.6.001209. eCollection 2015 Apr 1.


Nonlinear spectral imaging of human hypertrophic scar based on two-photon excited fluorescence and second-harmonic generation.

Chen G, Chen J, Zhuo S, Xiong S, Zeng H, Jiang X, Chen R, Xie S.

Br J Dermatol. 2009 Jul;161(1):48-55. doi: 10.1111/j.1365-2133.2009.09094.x. Epub 2009 Mar 20.


Quantitative imaging of fibrotic and morphological changes in liver of non-alcoholic steatohepatitis (NASH) model mice by second harmonic generation (SHG) and auto-fluorescence (AF) imaging using two-photon excitation microscopy (TPEM).

Yamamoto S, Oshima Y, Saitou T, Watanabe T, Miyake T, Yoshida O, Tokumoto Y, Abe M, Matsuura B, Hiasa Y, Imamura T.

Biochem Biophys Rep. 2016 Sep 25;8:277-283. doi: 10.1016/j.bbrep.2016.09.010. eCollection 2016 Dec.


Systematic quantification of histological patterns shows accuracy in reflecting cirrhotic remodeling.

Wang Y, Huang W, Li R, Yun Z, Zhu Y, Yang J, Liu H, Liu Z, Feng Q, Hou J.

J Gastroenterol Hepatol. 2017 Sep;32(9):1631-1639. doi: 10.1111/jgh.13722.


Experimenting liver fibrosis diagnostic by two photon excitation microscopy and Bag-of-Features image classification.

Stanciu SG, Xu S, Peng Q, Yan J, Stanciu GA, Welsch RE, So PT, Csucs G, Yu H.

Sci Rep. 2014 Apr 10;4:4636. doi: 10.1038/srep04636.


A robust collagen scoring method for human liver fibrosis by second harmonic microscopy.

Guilbert T, Odin C, Le Grand Y, Gailhouste L, Turlin B, Ezan F, Désille Y, Baffet G, Guyader D.

Opt Express. 2010 Dec 6;18(25):25794-807. doi: 10.1364/OE.18.025794.


Ultrasound Shear Wave Elastography for Liver Disease. A Critical Appraisal of the Many Actors on the Stage.

Piscaglia F, Salvatore V, Mulazzani L, Cantisani V, Schiavone C.

Ultraschall Med. 2016 Feb;37(1):1-5. doi: 10.1055/s-0035-1567037. Epub 2016 Feb 12.


Advanced septa size quantitation determines the evaluation of histological fibrosis outcome in chronic hepatitis B patients.

Wang B, Sun Y, Zhou J, Wu X, Chen S, Wu S, Liu H, Wang T, Ou X, Jia J, You H.

Mod Pathol. 2018 Oct;31(10):1567-1577. doi: 10.1038/s41379-018-0059-x. Epub 2018 May 21.


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