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HNF4α pathway mapping identifies wild-type IDH1 as a targetable metabolic node in gastric cancer.

Xu C, Ooi WF, Qamra A, Tan J, Chua BY, Ho SWT, Das K, Adam Isa ZF, Li Z, Yao X, Yan T, Xing M, Huang KK, Lin JS, Nandi T, Tay ST, Lee MH, Tan ALK, Ong X, Ashktorab H, Smoot D, Li S, Ng SC, Teh BT, Tan P.

Gut. 2019 May 8. pii: gutjnl-2018-318025. doi: 10.1136/gutjnl-2018-318025. [Epub ahead of print]


HNF4α is a therapeutic target that links AMPK to WNT signalling in early-stage gastric cancer.

Chang HR, Nam S, Kook MC, Kim KT, Liu X, Yao H, Jung HR, Lemos R Jr, Seo HH, Park HS, Gim Y, Hong D, Huh I, Kim YW, Tan D, Liu CG, Powis G, Park T, Liang H, Kim YH.

Gut. 2016 Jan;65(1):19-32. doi: 10.1136/gutjnl-2014-307918. Epub 2014 Nov 19.


Regulatory crosstalk between lineage-survival oncogenes KLF5, GATA4 and GATA6 cooperatively promotes gastric cancer development.

Chia NY, Deng N, Das K, Huang D, Hu L, Zhu Y, Lim KH, Lee MH, Wu J, Sam XX, Tan GS, Wan WK, Yu W, Gan A, Tan AL, Tay ST, Soo KC, Wong WK, Dominguez LT, Ng HH, Rozen S, Goh LK, Teh BT, Tan P.

Gut. 2015 May;64(5):707-19. doi: 10.1136/gutjnl-2013-306596. Epub 2014 Jul 22.


Berberine Attenuated Proliferation, Invasion and Migration by Targeting the AMPK/HNF4α/WNT5A Pathway in Gastric Carcinoma.

Hu Q, Li L, Zou X, Xu L, Yi P.

Front Pharmacol. 2018 Oct 19;9:1150. doi: 10.3389/fphar.2018.01150. eCollection 2018.


Mutual amplification of HNF4α and IL-1R1 composes an inflammatory circuit in Helicobacter pylori associated gastric carcinogenesis.

Ma L, Zeng J, Guo Q, Liang X, Shen L, Li S, Sun Y, Li W, Liu S, Yu H, Chen C, Jia J.

Oncotarget. 2016 Mar 8;7(10):11349-63. doi: 10.18632/oncotarget.7239.


Differential Effects of Hepatocyte Nuclear Factor 4α Isoforms on Tumor Growth and T-Cell Factor 4/AP-1 Interactions in Human Colorectal Cancer Cells.

Vuong LM, Chellappa K, Dhahbi JM, Deans JR, Fang B, Bolotin E, Titova NV, Hoverter NP, Spindler SR, Waterman ML, Sladek FM.

Mol Cell Biol. 2015 Oct;35(20):3471-90. doi: 10.1128/MCB.00030-15. Epub 2015 Aug 3.


Mutated IDH1 is a favorable prognostic factor for type 2 gliomatosis cerebri.

Kwon MJ, Kim ST, Kwon MJ, Kong DS, Lee D, Park S, Kang SY, Song JY, Nam DH, Kato Y, Choi YL, Suh YL.

Brain Pathol. 2012 May;22(3):307-17. doi: 10.1111/j.1750-3639.2011.00532.x. Epub 2011 Nov 14.


Complex interplay between the lipin 1 and the hepatocyte nuclear factor 4 α (HNF4α) pathways to regulate liver lipid metabolism.

Chen Z, Gropler MC, Mitra MS, Finck BN.

PLoS One. 2012;7(12):e51320. doi: 10.1371/journal.pone.0051320. Epub 2012 Dec 7.


Hepatocyte nuclear factor 4alpha is essential for embryonic development of the mouse colon.

Garrison WD, Battle MA, Yang C, Kaestner KH, Sladek FM, Duncan SA.

Gastroenterology. 2006 Apr;130(4):1207-20.


Hepatocyte-specific deletion of hepatocyte nuclear factor-4α in adult mice results in increased hepatocyte proliferation.

Walesky C, Gunewardena S, Terwilliger EF, Edwards G, Borude P, Apte U.

Am J Physiol Gastrointest Liver Physiol. 2013 Jan 1;304(1):G26-37. doi: 10.1152/ajpgi.00064.2012. Epub 2012 Oct 25.


Hepatocyte nuclear factor 4α suppresses the aggravation of colon carcinoma.

Yao HS, Wang J, Zhang XP, Wang LZ, Wang Y, Li XX, Jin KZ, Hu ZQ, Wang WJ.

Mol Carcinog. 2016 May;55(5):458-72. doi: 10.1002/mc.22294. Epub 2015 Mar 25.


Hepatic hepatocyte nuclear factor 4α is essential for maintaining triglyceride and cholesterol homeostasis.

Yin L, Ma H, Ge X, Edwards PA, Zhang Y.

Arterioscler Thromb Vasc Biol. 2011 Feb;31(2):328-36. doi: 10.1161/ATVBAHA.110.217828. Epub 2010 Nov 11.


Hepatocyte nuclear factor 4 alpha and farnesoid X receptor co-regulates gene transcription in mouse livers on a genome-wide scale.

Thomas AM, Hart SN, Li G, Lu H, Fang Y, Fang J, Zhong XB, Guo GL.

Pharm Res. 2013 Sep;30(9):2188-98. doi: 10.1007/s11095-013-1006-7. Epub 2013 Mar 6.


Comprehensive genomic meta-analysis identifies intra-tumoural stroma as a predictor of survival in patients with gastric cancer.

Wu Y, Grabsch H, Ivanova T, Tan IB, Murray J, Ooi CH, Wright AI, West NP, Hutchins GG, Wu J, Lee M, Lee J, Koo JH, Yeoh KG, van Grieken N, Ylstra B, Rha SY, Ajani JA, Cheong JH, Noh SH, Lim KH, Boussioutas A, Lee JS, Tan P.

Gut. 2013 Aug;62(8):1100-11. doi: 10.1136/gutjnl-2011-301373. Epub 2012 Jun 26.


An HNF4α-microRNA-194/192 signaling axis maintains hepatic cell function.

Morimoto A, Kannari M, Tsuchida Y, Sasaki S, Saito C, Matsuta T, Maeda T, Akiyama M, Nakamura T, Sakaguchi M, Nameki N, Gonzalez FJ, Inoue Y.

J Biol Chem. 2017 Jun 23;292(25):10574-10585. doi: 10.1074/jbc.M117.785592. Epub 2017 May 2.


The role of hepatocyte nuclear factor 4-alpha in perfluorooctanoic acid- and perfluorooctanesulfonic acid-induced hepatocellular dysfunction.

Beggs KM, McGreal SR, McCarthy A, Gunewardena S, Lampe JN, Lau C, Apte U.

Toxicol Appl Pharmacol. 2016 Aug 1;304:18-29. doi: 10.1016/j.taap.2016.05.001. Epub 2016 May 3.


In silico gene expression analysis reveals glycolysis and acetate anaplerosis in IDH1 wild-type glioma and lactate and glutamate anaplerosis in IDH1-mutated glioma.

Khurshed M, Molenaar RJ, Lenting K, Leenders WP, van Noorden CJF.

Oncotarget. 2017 Jul 25;8(30):49165-49177. doi: 10.18632/oncotarget.17106.


Intelectin 1 suppresses tumor progression and is associated with improved survival in gastric cancer.

Li D, Zhao X, Xiao Y, Mei H, Pu J, Xiang X, Jiao W, Song H, Qu H, Huang K, Zheng L, Tong Q.

Oncotarget. 2015 Jun 30;6(18):16168-82.

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