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Ipriflavone attenuates the degeneration of cartilage by blocking the Indian hedgehog pathway.

Guo L, Wei X, Zhang Z, Wang X, Wang C, Li P, Wang C, Wei L.

Arthritis Res Ther. 2019 May 2;21(1):109. doi: 10.1186/s13075-019-1895-x.


Activation of Indian hedgehog promotes chondrocyte hypertrophy and upregulation of MMP-13 in human osteoarthritic cartilage.

Wei F, Zhou J, Wei X, Zhang J, Fleming BC, Terek R, Pei M, Chen Q, Liu T, Wei L.

Osteoarthritis Cartilage. 2012 Jul;20(7):755-63. doi: 10.1016/j.joca.2012.03.010. Epub 2012 Mar 30.


Indian Hedgehog, a critical modulator in osteoarthritis, could be a potential therapeutic target for attenuating cartilage degeneration disease.

Zhou J, Wei X, Wei L.

Connect Tissue Res. 2014 Aug;55(4):257-61. doi: 10.3109/03008207.2014.925885. Epub 2014 Jun 13. Review.


Disrupting the Indian hedgehog signaling pathway in vivo attenuates surgically induced osteoarthritis progression in Col2a1-CreERT2; Ihhfl/fl mice.

Zhou J, Chen Q, Lanske B, Fleming BC, Terek R, Wei X, Zhang G, Wang S, Li K, Wei L.

Arthritis Res Ther. 2014 Jan 15;16(1):R11. doi: 10.1186/ar4437.


Identification of α2-macroglobulin as a master inhibitor of cartilage-degrading factors that attenuates the progression of posttraumatic osteoarthritis.

Wang S, Wei X, Zhou J, Zhang J, Li K, Chen Q, Terek R, Fleming BC, Goldring MB, Ehrlich MG, Zhang G, Wei L.

Arthritis Rheumatol. 2014 Jul;66(7):1843-53. doi: 10.1002/art.38576.


Abnormal Mechanical Loading Induces Cartilage Degeneration by Accelerating Meniscus Hypertrophy and Mineralization After ACL Injuries In Vivo.

Du G, Zhan H, Ding D, Wang S, Wei X, Wei F, Zhang J, Bilgen B, Reginato AM, Fleming BC, Deng J, Wei L.

Am J Sports Med. 2016 Mar;44(3):652-63. doi: 10.1177/0363546515621285. Epub 2016 Jan 20.


Hedgehog signal expression in articular cartilage of rat temporomandibular joint and association with adjuvant-induced osteoarthritis.

Xu T, Xu G, Gu Z, Wu H.

J Oral Pathol Med. 2017 Apr;46(4):284-291. doi: 10.1111/jop.12497. Epub 2016 Sep 20.


Targeted designed variants of alpha-2-macroglobulin (A2M) attenuate cartilage degeneration in a rat model of osteoarthritis induced by anterior cruciate ligament transection.

Zhang Y, Wei X, Browning S, Scuderi G, Hanna LS, Wei L.

Arthritis Res Ther. 2017 Jul 25;19(1):175. doi: 10.1186/s13075-017-1363-4.


Indian hedgehog signals independently of PTHrP to promote chondrocyte hypertrophy.

Mak KK, Kronenberg HM, Chuang PT, Mackem S, Yang Y.

Development. 2008 Jun;135(11):1947-56. doi: 10.1242/dev.018044. Epub 2008 Apr 23.


Hedgehog signalling does not stimulate cartilage catabolism and is inhibited by Interleukin-1β.

Thompson CL, Patel R, Kelly TA, Wann AK, Hung CT, Chapple JP, Knight MM.

Arthritis Res Ther. 2015 Dec 24;17:373. doi: 10.1186/s13075-015-0891-z.


Intra-Articular Injection of Cross-Linked Hyaluronic Acid-Dexamethasone Hydrogel Attenuates Osteoarthritis: An Experimental Study in a Rat Model of Osteoarthritis.

Zhang Z, Wei X, Gao J, Zhao Y, Zhao Y, Guo L, Chen C, Duan Z, Li P, Wei L.

Int J Mol Sci. 2016 Apr 15;17(4):411. doi: 10.3390/ijms17040411.


[In vitro effect of alendronate on chondrocytes and articular cartilage and subchondral bone in rabbit anterior cruciate ligament transection model].

Hu H, Zhang L, Li B, Zhang Y, Liu X, Tian F, Cheng T, Wang Z.

Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi. 2009 Dec;23(12):1474-81. Chinese.


Inhibition of cartilage degradation and suppression of PGE2 and MMPs expression by pomegranate fruit extract in a model of posttraumatic osteoarthritis.

Akhtar N, Khan NM, Ashruf OS, Haqqi TM.

Nutrition. 2017 Jan;33:1-13. doi: 10.1016/j.nut.2016.08.004. Epub 2016 Sep 2.


Indian hedgehog in synovial fluid is a novel marker for early cartilage lesions in human knee joint.

Zhang C, Wei X, Chen C, Cao K, Li Y, Jiao Q, Ding J, Zhou J, Fleming BC, Chen Q, Shang X, Wei L.

Int J Mol Sci. 2014 Apr 28;15(5):7250-65. doi: 10.3390/ijms15057250.


Fibroblast Growth Factor Receptor 3 Inhibits Osteoarthritis Progression in the Knee Joints of Adult Mice.

Tang J, Su N, Zhou S, Xie Y, Huang J, Wen X, Wang Z, Wang Q, Xu W, Du X, Chen H, Chen L.

Arthritis Rheumatol. 2016 Oct;68(10):2432-43. doi: 10.1002/art.39739.


Indian hedgehog contributes to human cartilage endplate degeneration.

Wang S, Yang K, Chen S, Wang J, Du G, Fan S, Wei L.

Eur Spine J. 2015 Aug;24(8):1720-8. doi: 10.1007/s00586-015-4000-4. Epub 2015 May 10.


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