Format
Sort by
Items per page

Send to

Choose Destination

Links from PubMed

Items: 1 to 20 of 107

1.

PIM kinases facilitate lentiviral evasion from SAMHD1 restriction via Vpx phosphorylation.

Miyakawa K, Matsunaga S, Yokoyama M, Nomaguchi M, Kimura Y, Nishi M, Kimura H, Sato H, Hirano H, Tamura T, Akari H, Miura T, Adachi A, Sawasaki T, Yamamoto N, Ryo A.

Nat Commun. 2019 Apr 23;10(1):1844. doi: 10.1038/s41467-019-09867-7.

2.

Immune Activation Influences SAMHD1 Expression and Vpx-mediated SAMHD1 Degradation during Chronic HIV-1 Infection.

Fu W, Qiu C, Zhou M, Zhu L, Yang Y, Qiu C, Zhang L, Xu X, Wang Y, Xu J, Zhang X.

Sci Rep. 2016 Dec 6;6:38162. doi: 10.1038/srep38162.

3.

Inhibition of Vpx-Mediated SAMHD1 and Vpr-Mediated Host Helicase Transcription Factor Degradation by Selective Disruption of Viral CRL4 (DCAF1) E3 Ubiquitin Ligase Assembly.

Wang H, Guo H, Su J, Rui Y, Zheng W, Gao W, Zhang W, Li Z, Liu G, Markham RB, Wei W, Yu XF.

J Virol. 2017 Apr 13;91(9). pii: e00225-17. doi: 10.1128/JVI.00225-17. Print 2017 May 1.

4.

Vpx overcomes a SAMHD1-independent block to HIV reverse transcription that is specific to resting CD4 T cells.

Baldauf HM, Stegmann L, Schwarz SM, Ambiel I, Trotard M, Martin M, Burggraf M, Lenzi GM, Lejk H, Pan X, Fregoso OI, Lim ES, Abraham L, Nguyen LA, Rutsch F, König R, Kim B, Emerman M, Fackler OT, Keppler OT.

Proc Natl Acad Sci U S A. 2017 Mar 7;114(10):2729-2734. doi: 10.1073/pnas.1613635114. Epub 2017 Feb 22.

5.

Degradation of SAMHD1 by Vpx Is Independent of Uncoating.

Jáuregui P, Logue EC, Schultz ML, Fung S, Landau NR.

J Virol. 2015 May;89(10):5701-13. doi: 10.1128/JVI.03575-14. Epub 2015 Mar 11.

6.

[Research Progress in Viral Protein Vpx induction of Proteasomal Degradation of the Antiviral Factor SAMHD1].

Hou J, Du J, Zhao K, Yu X.

Bing Du Xue Bao. 2016 May;32(3):355-60. Review. Chinese.

PMID:
29963825
7.

Evolutionary toggling of Vpx/Vpr specificity results in divergent recognition of the restriction factor SAMHD1.

Fregoso OI, Ahn J, Wang C, Mehrens J, Skowronski J, Emerman M.

PLoS Pathog. 2013;9(7):e1003496. doi: 10.1371/journal.ppat.1003496. Epub 2013 Jul 18.

8.

The efficiency of Vpx-mediated SAMHD1 antagonism does not correlate with the potency of viral control in HIV-2-infected individuals.

Yu H, Usmani SM, Borch A, Krämer J, Stürzel CM, Khalid M, Li X, Krnavek D, van der Ende ME, Osterhaus AD, Gruters RA, Kirchhoff F.

Retrovirology. 2013 Mar 5;10:27. doi: 10.1186/1742-4690-10-27.

9.

Structural Basis of Clade-specific Engagement of SAMHD1 (Sterile α Motif and Histidine/Aspartate-containing Protein 1) Restriction Factors by Lentiviral Viral Protein X (Vpx) Virulence Factors.

Wu Y, Koharudin LM, Mehrens J, DeLucia M, Byeon CH, Byeon IJ, Calero G, Ahn J, Gronenborn AM.

J Biol Chem. 2015 Jul 17;290(29):17935-45. doi: 10.1074/jbc.M115.665513. Epub 2015 Jun 4.

10.

A CRISPR screen for factors regulating SAMHD1 degradation identifies IFITMs as potent inhibitors of lentiviral particle delivery.

Roesch F, OhAinle M, Emerman M.

Retrovirology. 2018 Mar 20;15(1):26. doi: 10.1186/s12977-018-0409-2.

11.

Transcription and translation are primary targets of Pim kinase inhibitor SGI-1776 in mantle cell lymphoma.

Yang Q, Chen LS, Neelapu SS, Miranda RN, Medeiros LJ, Gandhi V.

Blood. 2012 Oct 25;120(17):3491-500. doi: 10.1182/blood-2012-02-412643. Epub 2012 Sep 6.

12.

Interplay of ancestral non-primate lentiviruses with the virus-restricting SAMHD1 proteins of their hosts.

Mereby SA, Maehigashi T, Holler JM, Kim DH, Schinazi RF, Kim B.

J Biol Chem. 2018 Oct 19;293(42):16402-16412. doi: 10.1074/jbc.RA118.004567. Epub 2018 Sep 4.

13.

Evolutionary and functional analyses of the interaction between the myeloid restriction factor SAMHD1 and the lentiviral Vpx protein.

Laguette N, Rahm N, Sobhian B, Chable-Bessia C, Münch J, Snoeck J, Sauter D, Switzer WM, Heneine W, Kirchhoff F, Delsuc F, Telenti A, Benkirane M.

Cell Host Microbe. 2012 Feb 16;11(2):205-17. doi: 10.1016/j.chom.2012.01.007. Epub 2012 Feb 1.

14.

HD domain of SAMHD1 influences Vpx-induced degradation at a post-interaction step.

Kang J, Hou J, Zhao K, Yu XF, Du J.

Biochem Biophys Res Commun. 2016 Feb 12;470(3):690-696. doi: 10.1016/j.bbrc.2016.01.080. Epub 2016 Jan 15.

PMID:
26779819
15.

SAMHD1 host restriction factor: a link with innate immune sensing of retrovirus infection.

Sze A, Olagnier D, Lin R, van Grevenynghe J, Hiscott J.

J Mol Biol. 2013 Dec 13;425(24):4981-94. doi: 10.1016/j.jmb.2013.10.022. Epub 2013 Oct 23. Review.

PMID:
24161438
16.

HIV/simian immunodeficiency virus (SIV) accessory virulence factor Vpx loads the host cell restriction factor SAMHD1 onto the E3 ubiquitin ligase complex CRL4DCAF1.

Ahn J, Hao C, Yan J, DeLucia M, Mehrens J, Wang C, Gronenborn AM, Skowronski J.

J Biol Chem. 2012 Apr 6;287(15):12550-8. doi: 10.1074/jbc.M112.340711. Epub 2012 Feb 23.

17.

A Cyclin-Binding Motif in Human SAMHD1 Is Required for Its HIV-1 Restriction, dNTPase Activity, Tetramer Formation, and Efficient Phosphorylation.

St Gelais C, Kim SH, Maksimova VV, Buzovetsky O, Knecht KM, Shepard C, Kim B, Xiong Y, Wu L.

J Virol. 2018 Feb 26;92(6). pii: e01787-17. doi: 10.1128/JVI.01787-17. Print 2018 Mar 15.

18.

Targeting of glioblastoma cell lines and glioma stem cells by combined PIM kinase and PI3K-p110α inhibition.

Iqbal A, Eckerdt F, Bell J, Nakano I, Giles FJ, Cheng SY, Lulla RR, Goldman S, Platanias LC.

Oncotarget. 2016 May 31;7(22):33192-201. doi: 10.18632/oncotarget.8899.

19.

SAMHD1: at the crossroads of cell proliferation, immune responses, and virus restriction.

Ballana E, Esté JA.

Trends Microbiol. 2015 Nov;23(11):680-692. doi: 10.1016/j.tim.2015.08.002. Epub 2015 Oct 1. Review.

PMID:
26439297
20.

Structural basis of lentiviral subversion of a cellular protein degradation pathway.

Schwefel D, Groom HC, Boucherit VC, Christodoulou E, Walker PA, Stoye JP, Bishop KN, Taylor IA.

Nature. 2014 Jan 9;505(7482):234-8. doi: 10.1038/nature12815. Epub 2013 Dec 15.

Supplemental Content

Support Center