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Quantitative proteomic analysis of a genetically induced prostate inflammation mouse model via custom 4-plex DiLeu isobaric labeling.

Hao L, Thomas S, Greer T, Vezina CM, Bajpai S, Ashok A, De Marzo AM, Bieberich CJ, Li L, Ricke WA.

Am J Physiol Renal Physiol. 2019 Jun 1;316(6):F1236-F1243. doi: 10.1152/ajprenal.00387.2018. Epub 2019 Apr 17.


High-Throughput Quantitative Proteomics Enabled by Mass Defect-Based 12-Plex DiLeu Isobaric Tags.

Frost DC, Li L.

Methods Mol Biol. 2016;1410:169-94. doi: 10.1007/978-1-4939-3524-6_10.


Development and characterization of novel 8-plex DiLeu isobaric labels for quantitative proteomics and peptidomics.

Frost DC, Greer T, Xiang F, Liang Z, Li L.

Rapid Commun Mass Spectrom. 2015 Jun 30;29(12):1115-24. doi: 10.1002/rcm.7201.


High-resolution enabled 12-plex DiLeu isobaric tags for quantitative proteomics.

Frost DC, Greer T, Li L.

Anal Chem. 2015 Feb 3;87(3):1646-54. doi: 10.1021/ac503276z. Epub 2014 Dec 8.


Custom 4-Plex DiLeu Isobaric Labels Enable Relative Quantification of Urinary Proteins in Men with Lower Urinary Tract Symptoms (LUTS).

Greer T, Hao L, Nechyporenko A, Lee S, Vezina CM, Ricke WA, Marker PC, Bjorling DE, Bushman W, Li L.

PLoS One. 2015 Aug 12;10(8):e0135415. doi: 10.1371/journal.pone.0135415. eCollection 2015.


Increased N,N-Dimethyl Leucine Isobaric Tag Multiplexing by a Combined Precursor Isotopic Labeling and Isobaric Tagging Approach.

Frost DC, Rust CJ, Robinson RAS, Li L.

Anal Chem. 2018 Sep 18;90(18):10664-10669. doi: 10.1021/acs.analchem.8b01301. Epub 2018 Sep 4.


N,N-dimethyl leucines as novel isobaric tandem mass tags for quantitative proteomics and peptidomics.

Xiang F, Ye H, Chen R, Fu Q, Li L.

Anal Chem. 2010 Apr 1;82(7):2817-25. doi: 10.1021/ac902778d.


Evaluation and Application of Dimethylated Amino Acids as Isobaric Tags for Quantitative Proteomics of the TGF-β/Smad3 Signaling Pathway.

Yu Q, Shi X, Greer T, Lietz CB, Kent KC, Li L.

J Proteome Res. 2016 Sep 2;15(9):3420-31. doi: 10.1021/acs.jproteome.6b00641. Epub 2016 Aug 10.


Relative Quantitation of Neuropeptides at Multiple Developmental Stages of the American Lobster Using N, N-Dimethyl Leucine Isobaric Tandem Mass Tags.

Jiang X, Xiang F, Jia C, Buchberger AR, Li L.

ACS Chem Neurosci. 2018 Aug 15;9(8):2054-2063. doi: 10.1021/acschemneuro.7b00521. Epub 2018 Feb 7.


Improving data quality and preserving HCD-generated reporter ions with EThcD for isobaric tag-based quantitative proteomics and proteome-wide PTM studies.

Yu Q, Shi X, Feng Y, Kent KC, Li L.

Anal Chim Acta. 2017 May 22;968:40-49. doi: 10.1016/j.aca.2017.03.003. Epub 2017 Mar 16.


Isobaric labeling and tandem mass spectrometry: a novel approach for profiling and quantifying proteins differentially expressed in amniotic fluid in preterm labor with and without intra-amniotic infection/inflammation.

Romero R, Kusanovic JP, Gotsch F, Erez O, Vaisbuch E, Mazaki-Tovi S, Moser A, Tam S, Leszyk J, Master SR, Juhasz P, Pacora P, Ogge G, Gomez R, Yoon BH, Yeo L, Hassan SS, Rogers WT.

J Matern Fetal Neonatal Med. 2010 Apr;23(4):261-80. doi: 10.3109/14767050903067386.


Quantitative, multiplexed workflow for deep analysis of human blood plasma and biomarker discovery by mass spectrometry.

Keshishian H, Burgess MW, Specht H, Wallace L, Clauser KR, Gillette MA, Carr SA.

Nat Protoc. 2017 Aug;12(8):1683-1701. doi: 10.1038/nprot.2017.054. Epub 2017 Jul 27.


Generation of multiple reporter ions from a single isobaric reagent increases multiplexing capacity for quantitative proteomics.

Braun CR, Bird GH, Wühr M, Erickson BK, Rad R, Walensky LD, Gygi SP, Haas W.

Anal Chem. 2015 Oct 6;87(19):9855-63. doi: 10.1021/acs.analchem.5b02307. Epub 2015 Sep 4.


Isobaric protein-level labeling strategy for serum glycoprotein quantification analysis by liquid chromatography-tandem mass spectrometry.

Nie S, Lo A, Zhu J, Wu J, Ruffin MT, Lubman DM.

Anal Chem. 2013 Jun 4;85(11):5353-7. doi: 10.1021/ac400838s. Epub 2013 May 17.


Deep Profiling of Proteome and Phosphoproteome by Isobaric Labeling, Extensive Liquid Chromatography, and Mass Spectrometry.

Bai B, Tan H, Pagala VR, High AA, Ichhaporia VP, Hendershot L, Peng J.

Methods Enzymol. 2017;585:377-395. doi: 10.1016/bs.mie.2016.10.007. Epub 2016 Dec 24.


Multiplexed, Quantitative Workflow for Sensitive Biomarker Discovery in Plasma Yields Novel Candidates for Early Myocardial Injury.

Keshishian H, Burgess MW, Gillette MA, Mertins P, Clauser KR, Mani DR, Kuhn EW, Farrell LA, Gerszten RE, Carr SA.

Mol Cell Proteomics. 2015 Sep;14(9):2375-93. doi: 10.1074/mcp.M114.046813. Epub 2015 Feb 27.


High-Resolution Enabled 5-plex Mass Defect-Based N, N-Dimethyl Leucine Tags for Quantitative Proteomics.

Zhong X, Frost DC, Li L.

Anal Chem. 2019 Jun 10. doi: 10.1021/acs.analchem.9b01691. [Epub ahead of print]


Quantitative urinary proteomics using stable isotope labelling by peptide dimethylation in patients with prostate cancer.

Li C, Zang T, Wrobel K, Huang JT, Nabi G.

Anal Bioanal Chem. 2015 May;407(12):3393-404. doi: 10.1007/s00216-015-8569-6. Epub 2015 Feb 28.


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