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Phosphotyrosine-dependent interaction between the kinases PKCθ and Zap70 promotes proximal TCR signaling.

Xie J, Han X, Zhao C, Canonigo-Balancio AJ, Yates JR 3rd, Li Y, Lillemeier BF, Altman A.

Sci Signal. 2019 Apr 16;12(577). pii: eaar3349. doi: 10.1126/scisignal.aar3349.


Positive feedback regulation of PLCgamma1/Ca(2+) signaling by PKCtheta in restimulated T cells via a Tec kinase-dependent pathway.

Altman A, Kaminski S, Busuttil V, Droin N, Hu J, Tadevosyan Y, Hipskind RA, Villalba M.

Eur J Immunol. 2004 Jul;34(7):2001-11.


Enhanced interaction between SEC2 mutant and TCR Vβ induces MHC II-independent activation of T cells via PKCθ/NF-κB and IL-2R/STAT5 signaling pathways.

Fu X, Xu M, Song Y, Li Y, Zhang H, Zhang J, Zhang C.

J Biol Chem. 2018 Dec 21;293(51):19771-19784. doi: 10.1074/jbc.RA118.003668. Epub 2018 Oct 23.


PKCθ and HIV-1 Transcriptional Regulator Tat Co-exist at the LTR Promoter in CD4(+) T Cells.

López-Huertas MR, Li J, Zafar A, Rodríguez-Mora S, García-Domínguez C, Mateos E, Alcamí J, Rao S, Coiras M.

Front Immunol. 2016 Feb 29;7:69. doi: 10.3389/fimmu.2016.00069. eCollection 2016.


Quantitative profiling of tyrosine phosphorylation revealed changes in the activity of the T cell receptor signaling pathway upon cisplatin-induced apoptosis.

Størvold GL, Landskron J, Strozynski M, Arntzen MØ, Koehler CJ, Kalland ME, Taskén K, Thiede B.

J Proteomics. 2013 Oct 8;91:344-57. doi: 10.1016/j.jprot.2013.07.019. Epub 2013 Aug 7.


Protein kinase Cθ C2 domain is a phosphotyrosine binding module that plays a key role in its activation.

Stahelin RV, Kong KF, Raha S, Tian W, Melowic HR, Ward KE, Murray D, Altman A, Cho W.

J Biol Chem. 2012 Aug 31;287(36):30518-28. doi: 10.1074/jbc.M112.391557. Epub 2012 Jul 11.


PKC-theta-mediated signal delivery from the TCR/CD28 surface receptors.

Isakov N, Altman A.

Front Immunol. 2012 Aug 22;3:273. doi: 10.3389/fimmu.2012.00273. eCollection 2012.


SPAK kinase is a substrate and target of PKCtheta in T-cell receptor-induced AP-1 activation pathway.

Li Y, Hu J, Vita R, Sun B, Tabata H, Altman A.

EMBO J. 2004 Mar 10;23(5):1112-22. Epub 2004 Feb 26.


Characterization of TCR-induced phosphorylation of PKCtheta in primary murine lymphocytes.

Thebault S, Ochoa-Garay J.

Mol Immunol. 2004 Feb;40(13):931-42.


Novel mutant mouse line emphasizes the importance of protein kinase C theta for CD4+ T lymphocyte activation.

Siegmund K, Thuille N, Posch N, Fresser F, Leitges M, Baier G.

Cell Commun Signal. 2019 May 28;17(1):56. doi: 10.1186/s12964-019-0364-0.


Novel protein kinase C θ: coronin 1A complex in T lymphocytes.

Siegmund K, Thuille N, Posch N, Fresser F, Baier G.

Cell Commun Signal. 2015 Mar 31;13:22. doi: 10.1186/s12964-015-0100-3.


Characterization of protein kinase C theta activation loop autophosphorylation and the kinase domain catalytic mechanism.

Czerwinski R, Aulabaugh A, Greco RM, Olland S, Malakian K, Wolfrom S, Lin L, Kriz R, Stahl M, Huang Y, Liu L, Chaudhary D.

Biochemistry. 2005 Jul 19;44(28):9563-73.


NF-kappa B activation induced by T cell receptor/CD28 costimulation is mediated by protein kinase C-theta.

Coudronniere N, Villalba M, Englund N, Altman A.

Proc Natl Acad Sci U S A. 2000 Mar 28;97(7):3394-9.


PKCθ-Mediated PDK1 Phosphorylation Enhances T Cell Activation by Increasing PDK1 Stability.

Kang JA, Choi H, Yang T, Cho SK, Park ZY, Park SG.

Mol Cells. 2017 Jan;40(1):37-44. doi: 10.14348/molcells.2017.2236. Epub 2017 Jan 26.


Crk adaptor proteins regulate CD3ζ chain phosphorylation and TCR/CD3 down-modulation in activated T cells.

Dong G, Kalifa R, Nath PR, Babichev Y, Gelkop S, Isakov N.

Cell Signal. 2017 Aug;36:117-126. doi: 10.1016/j.cellsig.2017.04.022. Epub 2017 Apr 29.


Translocation of PKC[theta] in T cells is mediated by a nonconventional, PI3-K- and Vav-dependent pathway, but does not absolutely require phospholipase C.

Villalba M, Bi K, Hu J, Altman Y, Bushway P, Reits E, Neefjes J, Baier G, Abraham RT, Altman A.

J Cell Biol. 2002 Apr 15;157(2):253-63. Epub 2002 Apr 15.


Phytocomponent 4-hydroxy-3-methoxycinnamaldehyde ablates T-cell activation by targeting protein kinase C-θ and its downstream pathways.

Akber U, Na BR, Ko YS, Lee HS, Kim HR, Kwon MS, Park ZY, Choi EJ, Han WC, Lee SH, Oh HM, Jun CD.

Int Immunopharmacol. 2015 Mar;25(1):130-40. doi: 10.1016/j.intimp.2015.01.020. Epub 2015 Jan 28. Erratum in: Int Immunopharmacol. 2015 Jun;26(2):439. Ko, You-Seung [corrected to Ko, Yoo-Seung].


Silencing ZAP70 prevents HSP65-induced reverse cholesterol transport and NF-κB activation in T cells.

Hu J, Luo T, Xi D, Guo K, Hu L, Zhao J, Chen S, Guo Z.

Biomed Pharmacother. 2018 Jun;102:271-277. doi: 10.1016/j.biopha.2018.03.082. Epub 2018 Mar 22.


Modulation of Orai1 and STIM1 by Cellular Factors.

Woo JS, Srikanth S, Gwack Y.

In: Kozak JA, Putney JW Jr., editors. Calcium Entry Channels in Non-Excitable Cells. Boca Raton (FL): CRC Press/Taylor & Francis; 2018. Chapter 4.


Regulation of T cell development by c-Cbl: essential role of Lck.

Chiang YJ, Hodes RJ.

Int Immunol. 2015 May;27(5):245-51. doi: 10.1093/intimm/dxu105. Epub 2014 Dec 4.

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