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Items: 1 to 20 of 101

1.

CDK12 loss in cancer cells affects DNA damage response genes through premature cleavage and polyadenylation.

Krajewska M, Dries R, Grassetti AV, Dust S, Gao Y, Huang H, Sharma B, Day DS, Kwiatkowski N, Pomaville M, Dodd O, Chipumuro E, Zhang T, Greenleaf AL, Yuan GC, Gray NS, Young RA, Geyer M, Gerber SA, George RE.

Nat Commun. 2019 Apr 15;10(1):1757. doi: 10.1038/s41467-019-09703-y.

2.

CDK12 regulates DNA repair genes by suppressing intronic polyadenylation.

Dubbury SJ, Boutz PL, Sharp PA.

Nature. 2018 Dec;564(7734):141-145. doi: 10.1038/s41586-018-0758-y. Epub 2018 Nov 28.

3.

Characterization of human cyclin-dependent kinase 12 (CDK12) and CDK13 complexes in C-terminal domain phosphorylation, gene transcription, and RNA processing.

Liang K, Gao X, Gilmore JM, Florens L, Washburn MP, Smith E, Shilatifard A.

Mol Cell Biol. 2015 Mar;35(6):928-38. doi: 10.1128/MCB.01426-14. Epub 2015 Jan 5.

4.

Ovarian carcinoma CDK12 mutations misregulate expression of DNA repair genes via deficient formation and function of the Cdk12/CycK complex.

Ekumi KM, Paculova H, Lenasi T, Pospichalova V, Bösken CA, Rybarikova J, Bryja V, Geyer M, Blazek D, Barboric M.

Nucleic Acids Res. 2015 Mar 11;43(5):2575-89. doi: 10.1093/nar/gkv101. Epub 2015 Feb 20.

5.

The Cyclin K/Cdk12 complex maintains genomic stability via regulation of expression of DNA damage response genes.

Blazek D, Kohoutek J, Bartholomeeusen K, Johansen E, Hulinkova P, Luo Z, Cimermancic P, Ule J, Peterlin BM.

Genes Dev. 2011 Oct 15;25(20):2158-72. doi: 10.1101/gad.16962311.

6.

CDK12 regulates alternative last exon mRNA splicing and promotes breast cancer cell invasion.

Tien JF, Mazloomian A, Cheng SG, Hughes CS, Chow CCT, Canapi LT, Oloumi A, Trigo-Gonzalez G, Bashashati A, Xu J, Chang VC, Shah SP, Aparicio S, Morin GB.

Nucleic Acids Res. 2017 Jun 20;45(11):6698-6716. doi: 10.1093/nar/gkx187.

7.

Role and therapeutic potential of CDK12 in human cancers.

Chilà R, Guffanti F, Damia G.

Cancer Treat Rev. 2016 Nov;50:83-88. doi: 10.1016/j.ctrv.2016.09.003. Epub 2016 Sep 14. Review.

PMID:
27662623
8.

CDK12: an emerging therapeutic target for cancer.

Lui GYL, Grandori C, Kemp CJ.

J Clin Pathol. 2018 Nov;71(11):957-962. doi: 10.1136/jclinpath-2018-205356. Epub 2018 Aug 13. Review.

PMID:
30104286
9.

Interaction of cyclin-dependent kinase 12/CrkRS with cyclin K1 is required for the phosphorylation of the C-terminal domain of RNA polymerase II.

Cheng SW, Kuzyk MA, Moradian A, Ichu TA, Chang VC, Tien JF, Vollett SE, Griffith M, Marra MA, Morin GB.

Mol Cell Biol. 2012 Nov;32(22):4691-704. doi: 10.1128/MCB.06267-11. Epub 2012 Sep 17.

10.

CDK12 phosphorylates 4E-BP1 to enable mTORC1-dependent translation and mitotic genome stability.

Choi SH, Martinez TF, Kim S, Donaldson C, Shokhirev MN, Saghatelian A, Jones KA.

Genes Dev. 2019 Apr 1;33(7-8):418-435. doi: 10.1101/gad.322339.118. Epub 2019 Feb 28.

PMID:
30819820
11.
12.

Evaluation of CDK12 Protein Expression as a Potential Novel Biomarker for DNA Damage Response-Targeted Therapies in Breast Cancer.

Naidoo K, Wai PT, Maguire SL, Daley F, Haider S, Kriplani D, Campbell J, Mirza H, Grigoriadis A, Tutt A, Moseley PM, Abdel-Fatah TMA, Chan SYT, Madhusudan S, Rhaka EA, Ellis IO, Lord CJ, Yuan Y, Green AR, Natrajan R.

Mol Cancer Ther. 2018 Jan;17(1):306-315. doi: 10.1158/1535-7163.MCT-17-0760. Epub 2017 Nov 13.

13.

BRCA1 or CDK12 loss sensitizes cells to CHK1 inhibitors.

Paculová H, Kramara J, Šimečková Š, Fedr R, Souček K, Hylse O, Paruch K, Svoboda M, Mistrík M, Kohoutek J.

Tumour Biol. 2017 Oct;39(10):1010428317727479. doi: 10.1177/1010428317727479.

PMID:
29025359
14.

Engineering an analog-sensitive CDK12 cell line using CRISPR/Cas.

Bartkowiak B, Yan C, Greenleaf AL.

Biochim Biophys Acta. 2015 Sep;1849(9):1179-87. doi: 10.1016/j.bbagrm.2015.07.010. Epub 2015 Jul 17.

15.

RNA Polymerase II Transcription Attenuation at the Yeast DNA Repair Gene, DEF1, Involves Sen1-Dependent and Polyadenylation Site-Dependent Termination.

Whalen C, Tuohy C, Tallo T, Kaufman JW, Moore C, Kuehner JN.

G3 (Bethesda). 2018 May 31;8(6):2043-2058. doi: 10.1534/g3.118.200072.

16.

Intronic cleavage and polyadenylation regulates gene expression during DNA damage response through U1 snRNA.

Devany E, Park JY, Murphy MR, Zakusilo G, Baquero J, Zhang X, Hoque M, Tian B, Kleiman FE.

Cell Discov. 2016 Jun 14;2:16013. doi: 10.1038/celldisc.2016.13. eCollection 2016.

17.

[Function of CDK12 in Tumor initiation and progression and its clinical consequences].

Vrábel D, Svoboda M, Navrátil J, Kohoutek J.

Klin Onkol. 2014;27(5):340-6. Review. Czech.

PMID:
25312711
18.

Cdk12 Regulates Neurogenesis and Late-Arising Neuronal Migration in the Developing Cerebral Cortex.

Chen HR, Juan HC, Wong YH, Tsai JW, Fann MJ.

Cereb Cortex. 2017 Mar 1;27(3):2289-2302. doi: 10.1093/cercor/bhw081.

PMID:
27073218
19.

Cyclin-dependent kinase 12 increases 3' end processing of growth factor-induced c-FOS transcripts.

Eifler TT, Shao W, Bartholomeeusen K, Fujinaga K, Jäger S, Johnson JR, Luo Z, Krogan NJ, Peterlin BM.

Mol Cell Biol. 2015 Jan;35(2):468-78. doi: 10.1128/MCB.01157-14. Epub 2014 Nov 10.

20.

Expression, purification, and identification of associated proteins of the full-length hCDK12/CyclinK complex.

Bartkowiak B, Greenleaf AL.

J Biol Chem. 2015 Jan 16;290(3):1786-95. doi: 10.1074/jbc.M114.612226. Epub 2014 Nov 26.

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