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Items: 1 to 20 of 98

1.

Growth Factor Independence 1B-Mediated Transcriptional Repression and Lineage Allocation Require Lysine-Specific Demethylase 1-Dependent Recruitment of the BHC Complex.

McClellan D, Casey MJ, Bareyan D, Lucente H, Ours C, Velinder M, Singer J, Lone MD, Sun W, Coria Y, Mason CC, Engel ME.

Mol Cell Biol. 2019 Jun 13;39(13). pii: e00020-19. doi: 10.1128/MCB.00020-19. Print 2019 Jul 1.

PMID:
30988160
2.

Selective dissociation between LSD1 and GFI1B by a LSD1 inhibitor NCD38 induces the activation of ERG super-enhancer in erythroleukemia cells.

Yamamoto R, Kawahara M, Ito S, Satoh J, Tatsumi G, Hishizawa M, Suzuki T, Andoh A.

Oncotarget. 2018 Apr 20;9(30):21007-21021. doi: 10.18632/oncotarget.24774. eCollection 2018 Apr 20.

3.

Differential transcriptional regulation of meis1 by Gfi1b and its co-factors LSD1 and CoREST.

Chowdhury AH, Ramroop JR, Upadhyay G, Sengupta A, Andrzejczyk A, Saleque S.

PLoS One. 2013;8(1):e53666. doi: 10.1371/journal.pone.0053666. Epub 2013 Jan 7.

4.

Antagonistic actions of Rcor proteins regulate LSD1 activity and cellular differentiation.

Upadhyay G, Chowdhury AH, Vaidyanathan B, Kim D, Saleque S.

Proc Natl Acad Sci U S A. 2014 Jun 3;111(22):8071-6. doi: 10.1073/pnas.1404292111. Epub 2014 May 19.

5.

A Novel LSD1 Inhibitor T-3775440 Disrupts GFI1B-Containing Complex Leading to Transdifferentiation and Impaired Growth of AML Cells.

Ishikawa Y, Gamo K, Yabuki M, Takagi S, Toyoshima K, Nakayama K, Nakayama A, Morimoto M, Miyashita H, Dairiki R, Hikichi Y, Tomita N, Tomita D, Imamura S, Iwatani M, Kamada Y, Matsumoto S, Hara R, Nomura T, Tsuchida K, Nakamura K.

Mol Cancer Ther. 2017 Feb;16(2):273-284. doi: 10.1158/1535-7163.MCT-16-0471. Epub 2016 Nov 30.

6.

Cooperative Stimulation of Megakaryocytic Differentiation by Gfi1b Gene Targets Kindlin3 and Talin1.

Singh D, Upadhyay G, Sengupta A, Biplob MA, Chakyayil S, George T, Saleque S.

PLoS One. 2016 Oct 21;11(10):e0164506. doi: 10.1371/journal.pone.0164506. eCollection 2016.

7.

SUMOylation Regulates Growth Factor Independence 1 in Transcriptional Control and Hematopoiesis.

Andrade D, Velinder M, Singer J, Maese L, Bareyan D, Nguyen H, Chandrasekharan MB, Lucente H, McClellan D, Jones D, Sharma S, Liu F, Engel ME.

Mol Cell Biol. 2016 May 2;36(10):1438-50. doi: 10.1128/MCB.01001-15. Print 2016 May 15.

8.
9.

Molecular mechanisms of bleeding disorderassociated GFI1BQ287* mutation and its affected pathways in megakaryocytes and platelets.

van Oorschot R, Hansen M, Koornneef JM, Marneth AE, Bergevoet SM, van Bergen MGJM, van Alphen FPJ, van der Zwaan C, Martens JHA, Vermeulen M, Jansen PWTC, Baltissen MPA, Gorkom BAPL, Janssen H, Jansen JH, von Lindern M, Meijer AB, van den Akker E, van der Reijden BA.

Haematologica. 2019 Jul;104(7):1460-1472. doi: 10.3324/haematol.2018.194555. Epub 2019 Jan 17.

10.

HMG20A is required for SNAI1-mediated epithelial to mesenchymal transition.

Rivero S, Ceballos-Chávez M, Bhattacharya SS, Reyes JC.

Oncogene. 2015 Oct 8;34(41):5264-76. doi: 10.1038/onc.2014.446. Epub 2015 Feb 2.

PMID:
25639869
11.

LSD1-mediated epigenetic modification is required for TAL1 function and hematopoiesis.

Hu X, Li X, Valverde K, Fu X, Noguchi C, Qiu Y, Huang S.

Proc Natl Acad Sci U S A. 2009 Jun 23;106(25):10141-6. doi: 10.1073/pnas.0900437106. Epub 2009 Jun 3.

12.

LSD1 Inhibitor T-3775440 Inhibits SCLC Cell Proliferation by Disrupting LSD1 Interactions with SNAG Domain Proteins INSM1 and GFI1B.

Takagi S, Ishikawa Y, Mizutani A, Iwasaki S, Matsumoto S, Kamada Y, Nomura T, Nakamura K.

Cancer Res. 2017 Sep 1;77(17):4652-4662. doi: 10.1158/0008-5472.CAN-16-3502. Epub 2017 Jun 30.

13.

GFI1 functions in transcriptional control and cell fate determination require SNAG domain methylation to recruit LSD1.

Velinder M, Singer J, Bareyan D, Meznarich J, Tracy CM, Fulcher JM, McClellan D, Lucente H, Franklin S, Sharma S, Engel ME.

Biochem J. 2016 Oct 1;473(19):3355-69. doi: 10.1042/BCJ20160558. Epub 2016 Aug 1. Erratum in: Biochem J. 2017 Aug 11;474(17 ):2951.

PMID:
27480105
14.

The DNA binding factor Hmg20b is a repressor of erythroid differentiation.

Esteghamat F, van Dijk TB, Braun H, Dekker S, van der Linden R, Hou J, Fanis P, Demmers J, van IJcken W, Ozgür Z, Horos R, Pourfarzad F, von Lindern M, Philipsen S.

Haematologica. 2011 Sep;96(9):1252-60. doi: 10.3324/haematol.2011.045211. Epub 2011 May 23.

15.

Phosphorylation of neuronal Lysine-Specific Demethylase 1LSD1/KDM1A impairs transcriptional repression by regulating interaction with CoREST and histone deacetylases HDAC1/2.

Toffolo E, Rusconi F, Paganini L, Tortorici M, Pilotto S, Heise C, Verpelli C, Tedeschi G, Maffioli E, Sala C, Mattevi A, Battaglioli E.

J Neurochem. 2014 Mar;128(5):603-16. doi: 10.1111/jnc.12457. Epub 2013 Oct 23.

16.

Lysine-specific demethylase 1 restricts hematopoietic progenitor proliferation and is essential for terminal differentiation.

Sprüssel A, Schulte JH, Weber S, Necke M, Händschke K, Thor T, Pajtler KW, Schramm A, König K, Diehl L, Mestdagh P, Vandesompele J, Speleman F, Jastrow H, Heukamp LC, Schüle R, Dührsen U, Buettner R, Eggert A, Göthert JR.

Leukemia. 2012 Sep;26(9):2039-51. doi: 10.1038/leu.2012.157. Epub 2012 Jun 13.

PMID:
22699452
17.

Histone lysine-specific demethylase 1 (LSD1) protein is involved in Sal-like protein 4 (SALL4)-mediated transcriptional repression in hematopoietic stem cells.

Liu L, Souto J, Liao W, Jiang Y, Li Y, Nishinakamura R, Huang S, Rosengart T, Yang VW, Schuster M, Ma Y, Yang J.

J Biol Chem. 2013 Nov 29;288(48):34719-28. doi: 10.1074/jbc.M113.506568. Epub 2013 Oct 25.

18.

Growth factor independence 1b (gfi1b) is important for the maturation of erythroid cells and the regulation of embryonic globin expression.

Vassen L, Beauchemin H, Lemsaddek W, Krongold J, Trudel M, Möröy T.

PLoS One. 2014 May 6;9(5):e96636. doi: 10.1371/journal.pone.0096636. eCollection 2014.

19.

GATA-1 utilizes Ikaros and polycomb repressive complex 2 to suppress Hes1 and to promote erythropoiesis.

Ross J, Mavoungou L, Bresnick EH, Milot E.

Mol Cell Biol. 2012 Sep;32(18):3624-38. doi: 10.1128/MCB.00163-12. Epub 2012 Jul 9.

20.

Transcription Factor GFI1B in Health and Disease.

Anguita E, Candel FJ, Chaparro A, Roldán-Etcheverry JJ.

Front Oncol. 2017 Mar 28;7:54. doi: 10.3389/fonc.2017.00054. eCollection 2017. Review.

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