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Items: 1 to 20 of 110

1.

Geometric singular perturbation analysis of a dynamical target mediated drug disposition model.

Kristiansen KU.

J Math Biol. 2019 Jul;79(1):187-222. doi: 10.1007/s00285-019-01354-3. Epub 2019 Apr 10.

PMID:
30972439
2.

Incorporating target-mediated drug disposition in a minimal physiologically-based pharmacokinetic model for monoclonal antibodies.

Cao Y, Jusko WJ.

J Pharmacokinet Pharmacodyn. 2014 Aug;41(4):375-87. doi: 10.1007/s10928-014-9372-2. Epub 2014 Jul 31.

3.

Asymptotic Analysis of a Target-Mediated Drug Disposition Model: Algorithmic and Traditional Approaches.

Patsatzis DG, Maris DT, Goussis DA.

Bull Math Biol. 2016 Jun;78(6):1121-61. doi: 10.1007/s11538-016-0176-y. Epub 2016 Jun 8.

PMID:
27271122
4.

A geometric analysis of fast-slow models for stochastic gene expression.

Popović N, Marr C, Swain PS.

J Math Biol. 2016 Jan;72(1-2):87-122. doi: 10.1007/s00285-015-0876-1. Epub 2015 Apr 2.

PMID:
25833185
5.

Target-mediated drug disposition model for drugs that bind to more than one target.

Gibiansky L, Gibiansky E.

J Pharmacokinet Pharmacodyn. 2010 Aug;37(4):323-46. doi: 10.1007/s10928-010-9163-3. Epub 2010 Jul 29.

PMID:
20669044
6.

Asymptotic analysis of a TMDD model: when a reaction contributes to the destruction of its product.

Michalaki LI, Goussis DA.

J Math Biol. 2018 Sep;77(3):821-855. doi: 10.1007/s00285-018-1234-x. Epub 2018 Apr 19.

PMID:
29675601
7.

Target-mediated drug disposition model: approximations, identifiability of model parameters and applications to the population pharmacokinetic-pharmacodynamic modeling of biologics.

Gibiansky L, Gibiansky E.

Expert Opin Drug Metab Toxicol. 2009 Jul;5(7):803-12. doi: 10.1517/17425250902992901. Review.

PMID:
19505189
8.

Target-mediated drug disposition model: relationships with indirect response models and application to population PK-PD analysis.

Gibiansky L, Gibiansky E.

J Pharmacokinet Pharmacodyn. 2009 Aug;36(4):341-51. doi: 10.1007/s10928-009-9125-9. Epub 2009 Jul 4.

PMID:
19578985
9.

Target-mediated drug disposition and dynamics.

Mager DE.

Biochem Pharmacol. 2006 Jun 28;72(1):1-10. Epub 2006 Feb 15. Review.

PMID:
16469301
10.

Target mediated drug disposition with drug-drug interaction, Part II: competitive and uncompetitive cases.

Koch G, Jusko WJ, Schropp J.

J Pharmacokinet Pharmacodyn. 2017 Feb;44(1):27-42. doi: 10.1007/s10928-016-9502-0. Epub 2017 Jan 10.

11.

Quasi-equilibrium pharmacokinetic model for drugs exhibiting target-mediated drug disposition.

Mager DE, Krzyzanski W.

Pharm Res. 2005 Oct;22(10):1589-96. Epub 2005 Sep 22.

PMID:
16180117
12.

Physiologically-based pharmacokinetic modeling to predict the clinical pharmacokinetics of monoclonal antibodies.

Glassman PM, Balthasar JP.

J Pharmacokinet Pharmacodyn. 2016 Aug;43(4):427-46. doi: 10.1007/s10928-016-9482-0. Epub 2016 Jul 4.

PMID:
27377311
13.

General Pharmacokinetic Features of Small-Molecule Compounds Exhibiting Target-Mediated Drug Disposition (TMDD): A Simulation-Based Study.

Bach T, Jiang Y, Zhang X, An G.

J Clin Pharmacol. 2019 Mar;59(3):394-405. doi: 10.1002/jcph.1335. Epub 2018 Nov 2.

PMID:
30387863
14.

Target-mediated drug disposition model for drugs with two binding sites that bind to a target with one binding site.

Gibiansky L, Gibiansky E.

J Pharmacokinet Pharmacodyn. 2017 Oct;44(5):463-475. doi: 10.1007/s10928-017-9533-1. Epub 2017 Jul 19.

PMID:
28725976
15.

Dynamics of target-mediated drug disposition: characteristic profiles and parameter identification.

Peletier LA, Gabrielsson J.

J Pharmacokinet Pharmacodyn. 2012 Oct;39(5):429-51. doi: 10.1007/s10928-012-9260-6. Epub 2012 Aug 1.

16.

Selection between Michaelis-Menten and target-mediated drug disposition pharmacokinetic models.

Yan X, Mager DE, Krzyzanski W.

J Pharmacokinet Pharmacodyn. 2010 Feb;37(1):25-47. doi: 10.1007/s10928-009-9142-8. Epub 2009 Dec 10.

17.

Mathematical description of drug-target interactions: application to biologics that bind to targets with two binding sites.

Gibiansky L, Gibiansky E.

J Pharmacokinet Pharmacodyn. 2018 Feb;45(1):23-34. doi: 10.1007/s10928-017-9546-9. Epub 2017 Sep 16.

PMID:
28918570
18.

The computation of biomarkers in pharmacokinetics with the aid of singular perturbation methods.

Ma J, Keener JP.

J Math Biol. 2018 Nov;77(5):1407-1430. doi: 10.1007/s00285-018-1257-3. Epub 2018 Jul 28.

PMID:
30056506
19.

Dynamics of target-mediated drug disposition.

Peletier LA, Gabrielsson J.

Eur J Pharm Sci. 2009 Dec 8;38(5):445-64. doi: 10.1016/j.ejps.2009.09.007. Epub 2009 Sep 26.

PMID:
19786099
20.

Geometric analysis of the Goldbeter minimal model for the embryonic cell cycle.

Kosiuk I, Szmolyan P.

J Math Biol. 2016 Apr;72(5):1337-68. doi: 10.1007/s00285-015-0905-0. Epub 2015 Jun 23.

PMID:
26100376

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