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Items: 1 to 20 of 100

1.

MAGI1 as a link between endothelial activation and ER stress drives atherosclerosis.

Abe JI, Ko KA, Kotla S, Wang Y, Paez-Mayorga J, Shin IJ, Imanishi M, Vu HT, Tao Y, Leiva-Juarez MM, Thomas TN, Medina JL, Won JH, Fujii Y, Giancursio CJ, McBeath E, Shin JH, Guzman L, Abe RJ, Taunton J, Mochizuki N, Faubion W, Cooke JP, Fujiwara K, Evans SE, Le NT.

JCI Insight. 2019 Apr 4;4(7). pii: 125570. doi: 10.1172/jci.insight.125570. eCollection 2019 Apr 4.

2.

Disturbed flow-activated p90RSK kinase accelerates atherosclerosis by inhibiting SENP2 function.

Heo KS, Le NT, Cushman HJ, Giancursio CJ, Chang E, Woo CH, Sullivan MA, Taunton J, Yeh ET, Fujiwara K, Abe J.

J Clin Invest. 2015 Mar 2;125(3):1299-310. doi: 10.1172/JCI76453. Epub 2015 Feb 17.

3.

Endothelial senescence is induced by phosphorylation and nuclear export of telomeric repeat binding factor 2-interacting protein.

Kotla S, Vu HT, Ko KA, Wang Y, Imanishi M, Heo KS, Fujii Y, Thomas TN, Gi YJ, Mazhar H, Paez-Mayorga J, Shin JH, Tao Y, Giancursio CJ, Medina JL, Taunton J, Lusis AJ, Cooke JP, Fujiwara K, Le NT, Abe JI.

JCI Insight. 2019 May 2;4(9). pii: 124867. doi: 10.1172/jci.insight.124867. eCollection 2019 May 2.

4.

MAGI1 Mediates eNOS Activation and NO Production in Endothelial Cells in Response to Fluid Shear Stress.

Ghimire K, Zaric J, Alday-Parejo B, Seebach J, Bousquenaud M, Stalin J, Bieler G, Schnittler HJ, Rüegg C.

Cells. 2019 Apr 27;8(5). pii: E388. doi: 10.3390/cells8050388.

5.

Ursodeoxycholic Acid (UDCA) Exerts Anti-Atherogenic Effects by Inhibiting Endoplasmic Reticulum (ER) Stress Induced by Disturbed Flow.

Chung J, Kim KH, Lee SC, An SH, Kwon K.

Mol Cells. 2015 Oct;38(10):851-8. doi: 10.14348/molcells.2015.0094. Epub 2015 Oct 7.

6.

A crucial role for p90RSK-mediated reduction of ERK5 transcriptional activity in endothelial dysfunction and atherosclerosis.

Le NT, Heo KS, Takei Y, Lee H, Woo CH, Chang E, McClain C, Hurley C, Wang X, Li F, Xu H, Morrell C, Sullivan MA, Cohen MS, Serafimova IM, Taunton J, Fujiwara K, Abe J.

Circulation. 2013 Jan 29;127(4):486-99. doi: 10.1161/CIRCULATIONAHA.112.116988. Epub 2012 Dec 14.

7.

De-SUMOylation enzyme of sentrin/SUMO-specific protease 2 regulates disturbed flow-induced SUMOylation of ERK5 and p53 that leads to endothelial dysfunction and atherosclerosis.

Heo KS, Chang E, Le NT, Cushman H, Yeh ET, Fujiwara K, Abe J.

Circ Res. 2013 Mar 15;112(6):911-23. doi: 10.1161/CIRCRESAHA.111.300179. Epub 2013 Feb 4.

8.

Ionizing Radiation Induces Endothelial Inflammation and Apoptosis via p90RSK-Mediated ERK5 S496 Phosphorylation.

Vu HT, Kotla S, Ko KA, Fujii Y, Tao Y, Medina J, Thomas T, Hada M, Sood AK, Singh PK, Milgrom SA, Krishnan S, Fujiwara K, Le NT, Abe JI.

Front Cardiovasc Med. 2018 Mar 14;5:23. doi: 10.3389/fcvm.2018.00023. eCollection 2018.

9.

Endothelial senescence-associated secretory phenotype (SASP) is regulated by Makorin-1 ubiquitin E3 ligase.

Kotla S, Le NT, Vu HT, Ko KA, Gi YJ, Thomas TN, Giancursio C, Lusis AJ, Cooke JP, Fujiwara K, Abe JI.

Metabolism. 2019 Nov;100:153962. doi: 10.1016/j.metabol.2019.153962. Epub 2019 Aug 30.

PMID:
31476350
10.

Disturbed flow promotes endothelial senescence via a p53-dependent pathway.

Warboys CM, de Luca A, Amini N, Luong L, Duckles H, Hsiao S, White A, Biswas S, Khamis R, Chong CK, Cheung WM, Sherwin SJ, Bennett MR, Gil J, Mason JC, Haskard DO, Evans PC.

Arterioscler Thromb Vasc Biol. 2014 May;34(5):985-95. doi: 10.1161/ATVBAHA.114.303415. Epub 2014 Mar 20.

PMID:
24651677
11.

Reactive oxygen species activate p90 ribosomal S6 kinase via Fyn and Ras.

Abe J, Okuda M, Huang Q, Yoshizumi M, Berk BC.

J Biol Chem. 2000 Jan 21;275(3):1739-48.

12.

Activation of the endoplasmic reticulum stress response by the amyloid-beta 1-40 peptide in brain endothelial cells.

Fonseca AC, Ferreiro E, Oliveira CR, Cardoso SM, Pereira CF.

Biochim Biophys Acta. 2013 Dec;1832(12):2191-203. doi: 10.1016/j.bbadis.2013.08.007. Epub 2013 Aug 28.

13.

Interleukin-10 blocked endoplasmic reticulum stress in intestinal epithelial cells: impact on chronic inflammation.

Shkoda A, Ruiz PA, Daniel H, Kim SC, Rogler G, Sartor RB, Haller D.

Gastroenterology. 2007 Jan;132(1):190-207. Epub 2006 Oct 21.

PMID:
17241871
14.

Disturbed Flow-Induced Endothelial Proatherogenic Signaling Via Regulating Post-Translational Modifications and Epigenetic Events.

Heo KS, Berk BC, Abe J.

Antioxid Redox Signal. 2016 Sep 1;25(7):435-50. doi: 10.1089/ars.2015.6556. Epub 2016 Apr 5. Review.

15.

Acetylcholine ameliorates endoplasmic reticulum stress in endothelial cells after hypoxia/reoxygenation via M3 AChR-AMPK signaling.

Bi X, He X, Xu M, Zhao M, Yu X, Lu X, Zang W.

Cell Cycle. 2015 Aug 3;14(15):2461-72. doi: 10.1080/15384101.2015.1060383. Epub 2015 Jun 11.

16.

Flow signaling and atherosclerosis.

Le NT, Sandhu UG, Quintana-Quezada RA, Hoang NM, Fujiwara K, Abe JI.

Cell Mol Life Sci. 2017 May;74(10):1835-1858. doi: 10.1007/s00018-016-2442-4. Epub 2016 Dec 30. Review.

17.

Alteration of ceramide synthase 6/C16-ceramide induces activating transcription factor 6-mediated endoplasmic reticulum (ER) stress and apoptosis via perturbation of cellular Ca2+ and ER/Golgi membrane network.

Senkal CE, Ponnusamy S, Manevich Y, Meyers-Needham M, Saddoughi SA, Mukhopadyay A, Dent P, Bielawski J, Ogretmen B.

J Biol Chem. 2011 Dec 9;286(49):42446-58. doi: 10.1074/jbc.M111.287383. Epub 2011 Oct 19.

18.

Differential regulations of fibronectin and laminin in Smad2 activation in vascular endothelial cells in response to disturbed flow.

Yang TL, Lee PL, Lee DY, Wang WL, Wei SY, Lee CI, Chiu JJ.

J Biomed Sci. 2018 Jan 2;25(1):1. doi: 10.1186/s12929-017-0402-4.

19.

Role of endoplasmic reticulum stress in 12/15-lipoxygenase-induced retinal microvascular dysfunction in a mouse model of diabetic retinopathy.

Elmasry K, Ibrahim AS, Saleh H, Elsherbiny N, Elshafey S, Hussein KA, Al-Shabrawey M.

Diabetologia. 2018 May;61(5):1220-1232. doi: 10.1007/s00125-018-4560-z. Epub 2018 Feb 21.

20.

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