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mTORC1 underlies age-related muscle fiber damage and loss by inducing oxidative stress and catabolism.

Tang H, Inoki K, Brooks SV, Okazawa H, Lee M, Wang J, Kim M, Kennedy CL, Macpherson PCD, Ji X, Van Roekel S, Fraga DA, Wang K, Zhu J, Wang Y, Sharp ZD, Miller RA, Rando TA, Goldman D, Guan KL, Shrager JB.

Aging Cell. 2019 Jun;18(3):e12943. doi: 10.1111/acel.12943. Epub 2019 Mar 29.


Differential response of skeletal muscles to mTORC1 signaling during atrophy and hypertrophy.

Bentzinger CF, Lin S, Romanino K, Castets P, Guridi M, Summermatter S, Handschin C, Tintignac LA, Hall MN, Rüegg MA.

Skelet Muscle. 2013 Mar 6;3(1):6. doi: 10.1186/2044-5040-3-6.


Mouse skeletal muscle fiber-type-specific macroautophagy and muscle wasting are regulated by a Fyn/STAT3/Vps34 signaling pathway.

Yamada E, Bastie CC, Koga H, Wang Y, Cuervo AM, Pessin JE.

Cell Rep. 2012 May 31;1(5):557-69. doi: 10.1016/j.celrep.2012.03.014. Epub 2012 May 3.


Skeletal muscle-specific knockout of DEP domain containing 5 protein increases mTORC1 signaling, muscle cell hypertrophy, and mitochondrial respiration.

Graber TG, Fry CS, Brightwell CR, Moro T, Maroto R, Bhattarai N, Porter C, Wakamiya M, Rasmussen BB.

J Biol Chem. 2019 Mar 15;294(11):4091-4102. doi: 10.1074/jbc.RA118.005970. Epub 2019 Jan 11.


Induction of Growth Differentiation Factor 15 in Skeletal Muscle of Old Taurine Transporter Knockout Mouse.

Ito T, Nakanishi Y, Yamaji N, Murakami S, Schaffer SW.

Biol Pharm Bull. 2018;41(3):435-439. doi: 10.1248/bpb.b17-00969.


Apoptosis and necrosis mediate skeletal muscle fiber loss in age-induced mitochondrial enzymatic abnormalities.

Cheema N, Herbst A, McKenzie D, Aiken JM.

Aging Cell. 2015 Dec;14(6):1085-93. doi: 10.1111/acel.12399. Epub 2015 Sep 14.


Long-term administration of the mitochondria-targeted antioxidant mitoquinone mesylate fails to attenuate age-related oxidative damage or rescue the loss of muscle mass and function associated with aging of skeletal muscle.

Sakellariou GK, Pearson T, Lightfoot AP, Nye GA, Wells N, Giakoumaki II, Griffiths RD, McArdle A, Jackson MJ.

FASEB J. 2016 Nov;30(11):3771-3785. Epub 2016 Aug 22.


Dietary restriction attenuates age-associated muscle atrophy by lowering oxidative stress in mice even in complete absence of CuZnSOD.

Jang YC, Liu Y, Hayworth CR, Bhattacharya A, Lustgarten MS, Muller FL, Chaudhuri A, Qi W, Li Y, Huang JY, Verdin E, Richardson A, Van Remmen H.

Aging Cell. 2012 Oct;11(5):770-82. doi: 10.1111/j.1474-9726.2012.00843.x. Epub 2012 Aug 2.


Loss of a Negative Regulator of mTORC1 Induces Aerobic Glycolysis and Altered Fiber Composition in Skeletal Muscle.

Dutchak PA, Estill-Terpack SJ, Plec AA, Zhao X, Yang C, Chen J, Ko B, Deberardinis RJ, Yu Y, Tu BP.

Cell Rep. 2018 May 15;23(7):1907-1914. doi: 10.1016/j.celrep.2018.04.058.


Denervated muscle fibers induce mitochondrial peroxide generation in neighboring innervated fibers: Role in muscle aging.

Pollock N, Staunton CA, Vasilaki A, McArdle A, Jackson MJ.

Free Radic Biol Med. 2017 Nov;112:84-92. doi: 10.1016/j.freeradbiomed.2017.07.017. Epub 2017 Jul 21.


Living in a box or call of the wild? Revisiting lifetime inactivity and sarcopenia.

Lawler JM, Hindle A.

Antioxid Redox Signal. 2011 Nov 1;15(9):2529-41. doi: 10.1089/ars.2011.3974. Epub 2011 Aug 8. Review.


REDD1 deletion prevents dexamethasone-induced skeletal muscle atrophy.

Britto FA, Begue G, Rossano B, Docquier A, Vernus B, Sar C, Ferry A, Bonnieu A, Ollendorff V, Favier FB.

Am J Physiol Endocrinol Metab. 2014 Dec 1;307(11):E983-93. doi: 10.1152/ajpendo.00234.2014. Epub 2014 Oct 14.


Increased superoxide in vivo accelerates age-associated muscle atrophy through mitochondrial dysfunction and neuromuscular junction degeneration.

Jang YC, Lustgarten MS, Liu Y, Muller FL, Bhattacharya A, Liang H, Salmon AB, Brooks SV, Larkin L, Hayworth CR, Richardson A, Van Remmen H.

FASEB J. 2010 May;24(5):1376-90. doi: 10.1096/fj.09-146308. Epub 2009 Dec 29.


Mitochondrial ROS regulate oxidative damage and mitophagy but not age-related muscle fiber atrophy.

Sakellariou GK, Pearson T, Lightfoot AP, Nye GA, Wells N, Giakoumaki II, Vasilaki A, Griffiths RD, Jackson MJ, McArdle A.

Sci Rep. 2016 Sep 29;6:33944. doi: 10.1038/srep33944.


Constitutive activation of CaMKKα signaling is sufficient but not necessary for mTORC1 activation and growth in mouse skeletal muscle.

Ferey JL, Brault JJ, Smith CA, Witczak CA.

Am J Physiol Endocrinol Metab. 2014 Oct 15;307(8):E686-94. doi: 10.1152/ajpendo.00322.2014. Epub 2014 Aug 26.


Metabolic adaptation of skeletal muscle to hyperammonemia drives the beneficial effects of l-leucine in cirrhosis.

Davuluri G, Krokowski D, Guan BJ, Kumar A, Thapaliya S, Singh D, Hatzoglou M, Dasarathy S.

J Hepatol. 2016 Nov;65(5):929-937. doi: 10.1016/j.jhep.2016.06.004. Epub 2016 Jun 16.


Impaired regeneration in calpain-3 null muscle is associated with perturbations in mTORC1 signaling and defective mitochondrial biogenesis.

Yalvac ME, Amornvit J, Braganza C, Chen L, Hussain SA, Shontz KM, Montgomery CL, Flanigan KM, Lewis S, Sahenk Z.

Skelet Muscle. 2017 Dec 14;7(1):27. doi: 10.1186/s13395-017-0146-6.


Alterations to mTORC1 signaling in the skeletal muscle differentially affect whole-body metabolism.

Guridi M, Kupr B, Romanino K, Lin S, Falcetta D, Tintignac L, Rüegg MA.

Skelet Muscle. 2016 Mar 21;6:13. doi: 10.1186/s13395-016-0084-8. eCollection 2016.


Comparison of Whole Body SOD1 Knockout with Muscle-Specific SOD1 Knockout Mice Reveals a Role for Nerve Redox Signaling in Regulation of Degenerative Pathways in Skeletal Muscle.

Sakellariou GK, McDonagh B, Porter H, Giakoumaki II, Earl KE, Nye GA, Vasilaki A, Brooks SV, Richardson A, Van Remmen H, McArdle A, Jackson MJ.

Antioxid Redox Signal. 2018 Feb 1;28(4):275-295. doi: 10.1089/ars.2017.7249. Epub 2017 Dec 12.

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