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Statins affect human glioblastoma and other cancers through TGF-β inhibition.

Xiao A, Brenneman B, Floyd D, Comeau L, Spurio K, Olmez I, Lee J, Nakano I, Godlewski J, Bronisz A, Kagaya N, Shin-Ya K, Purow B.

Oncotarget. 2019 Mar 1;10(18):1716-1728. doi: 10.18632/oncotarget.26733. eCollection 2019 Mar 1.


Statins inhibit blastocyst formation by preventing geranylgeranylation.

Alarcon VB, Marikawa Y.

Mol Hum Reprod. 2016 May;22(5):350-63. doi: 10.1093/molehr/gaw011. Epub 2016 Feb 7.


Lipophilic but not hydrophilic statins selectively induce cell death in gynaecological cancers expressing high levels of HMGCoA reductase.

Kato S, Smalley S, Sadarangani A, Chen-Lin K, Oliva B, Brañes J, Carvajal J, Gejman R, Owen GI, Cuello M.

J Cell Mol Med. 2010 May;14(5):1180-93. doi: 10.1111/j.1582-4934.2009.00771.x. Epub 2009 May 11.


Statin suppresses apoptosis in osteoblastic cells: role of transforming growth factor-beta-Smad3 pathway.

Kaji H, Naito J, Inoue Y, Sowa H, Sugimoto T, Chihara K.

Horm Metab Res. 2008 Nov;40(11):746-51. doi: 10.1055/s-0028-1082051. Epub 2008 Jul 11.


Essential role of TGF-beta/Smad pathway on statin dependent vascular smooth muscle cell regulation.

Rodríguez-Vita J, Sánchez-Galán E, Santamaría B, Sánchez-López E, Rodrigues-Díez R, Blanco-Colio LM, Egido J, Ortiz A, Ruiz-Ortega M.

PLoS One. 2008;3(12):e3959. doi: 10.1371/journal.pone.0003959. Epub 2008 Dec 17.


Simvastatin inhibits transforming growth factor-β1-induced expression of type I collagen, CTGF, and α-SMA in keloid fibroblasts.

Mun JH, Kim YM, Kim BS, Kim JH, Kim MB, Ko HC.

Wound Repair Regen. 2014 Jan-Feb;22(1):125-33. doi: 10.1111/wrr.12136. Epub 2013 Dec 13.


TGF-β is an inducer of ZEB1-dependent mesenchymal transdifferentiation in glioblastoma that is associated with tumor invasion.

Joseph JV, Conroy S, Tomar T, Eggens-Meijer E, Bhat K, Copray S, Walenkamp AM, Boddeke E, Balasubramanyian V, Wagemakers M, den Dunnen WF, Kruyt FA.

Cell Death Dis. 2014 Oct 2;5:e1443. doi: 10.1038/cddis.2014.395.


Statin-induced apoptosis via the suppression of ERK1/2 and Akt activation by inhibition of the geranylgeranyl-pyrophosphate biosynthesis in glioblastoma.

Yanae M, Tsubaki M, Satou T, Itoh T, Imano M, Yamazoe Y, Nishida S.

J Exp Clin Cancer Res. 2011 Aug 10;30:74. doi: 10.1186/1756-9966-30-74.


HMG-CoA reductase inhibitors decrease angiotensin II-induced vascular fibrosis: role of RhoA/ROCK and MAPK pathways.

Rupérez M, Rodrigues-Díez R, Blanco-Colio LM, Sánchez-López E, Rodríguez-Vita J, Esteban V, Carvajal G, Plaza JJ, Egido J, Ruiz-Ortega M.

Hypertension. 2007 Aug;50(2):377-83. Epub 2007 Jun 25.


Inhibition of RhoA/Rho-kinase pathway suppresses the expression of type I collagen induced by TGF-beta2 in human retinal pigment epithelial cells.

Itoh Y, Kimoto K, Imaizumi M, Nakatsuka K.

Exp Eye Res. 2007 Mar;84(3):464-72. Epub 2007 Jan 10.


Recent development in pleiotropic effects of statins on cardiovascular disease through regulation of transforming growth factor-beta superfamily.

Ma S, Ma CC.

Cytokine Growth Factor Rev. 2011 Jun;22(3):167-75. doi: 10.1016/j.cytogfr.2011.05.004. Epub 2011 Jun 22. Review.


Rho-dependent inhibition of the induction of connective tissue growth factor (CTGF) by HMG CoA reductase inhibitors (statins).

Eberlein M, Heusinger-Ribeiro J, Goppelt-Struebe M.

Br J Pharmacol. 2001 Aug;133(7):1172-80.


Statins reduce TGF-beta2-modulation of the extracellular matrix in cultured astrocytes of the human optic nerve head.

Kim ML, Sung KR, Shin JA, Young Yoon J, Jang J.

Exp Eye Res. 2017 Nov;164:55-63. doi: 10.1016/j.exer.2017.08.004. Epub 2017 Aug 5.


Statins reduce amyloid-beta production through inhibition of protein isoprenylation.

Ostrowski SM, Wilkinson BL, Golde TE, Landreth G.

J Biol Chem. 2007 Sep 14;282(37):26832-44. Epub 2007 Jul 23.


Resistance of glioblastoma-initiating cells to radiation mediated by the tumor microenvironment can be abolished by inhibiting transforming growth factor-β.

Hardee ME, Marciscano AE, Medina-Ramirez CM, Zagzag D, Narayana A, Lonning SM, Barcellos-Hoff MH.

Cancer Res. 2012 Aug 15;72(16):4119-29. doi: 10.1158/0008-5472.CAN-12-0546. Epub 2012 Jun 12.


Inhibiting HDAC1 Enhances the Anti-Cancer Effects of Statins through Downregulation of GGTase-Iβ Expression.

Li R, Gan YH.

Int J Mol Sci. 2017 May 8;18(5). pii: E1010. doi: 10.3390/ijms18051010.


Statin-induced inhibition of the Rho-signaling pathway activates PPARalpha and induces HDL apoA-I.

Martin G, Duez H, Blanquart C, Berezowski V, Poulain P, Fruchart JC, Najib-Fruchart J, Glineur C, Staels B.

J Clin Invest. 2001 Jun;107(11):1423-32.


Novel anti-glioblastoma agents and therapeutic combinations identified from a collection of FDA approved drugs.

Jiang P, Mukthavaram R, Chao Y, Bharati IS, Fogal V, Pastorino S, Cong X, Nomura N, Gallagher M, Abbasi T, Vali S, Pingle SC, Makale M, Kesari S.

J Transl Med. 2014 Jan 17;12:13. doi: 10.1186/1479-5876-12-13. Erratum in: J Transl Med. 2014;12:126. Mukthavavam, Rajesh [corrected to Mukthavaram, Rajesh].


3-Hydroxy-3-methylglutaryl CoA reductase inhibitors prevent high glucose-induced proliferation of mesangial cells via modulation of Rho GTPase/ p21 signaling pathway: Implications for diabetic nephropathy.

Danesh FR, Sadeghi MM, Amro N, Philips C, Zeng L, Lin S, Sahai A, Kanwar YS.

Proc Natl Acad Sci U S A. 2002 Jun 11;99(12):8301-5. Epub 2002 Jun 4.

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