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Items: 1 to 20 of 102


Morin enhances auranofin anticancer activity by up-regulation of DR4 and DR5 and modulation of Bcl-2 through reactive oxygen species generation in Hep3B human hepatocellular carcinoma cells.

Hwang-Bo H, Lee WS, Nagappan A, Kim HJ, Panchanathan R, Park C, Chang SH, Kim ND, Leem SH, Chang YC, Kwon TK, Cheong JH, Kim GS, Jung JM, Shin SC, Hong SC, Choi YH.

Phytother Res. 2019 May;33(5):1384-1393. doi: 10.1002/ptr.6329. Epub 2019 Mar 19.


Auranofin, an inhibitor of thioredoxin reductase, induces apoptosis in hepatocellular carcinoma Hep3B cells by generation of reactive oxygen species.

Hwang-Bo H, Jeong JW, Han MH, Park C, Hong SH, Kim GY, Moon SK, Cheong J, Kim WJ, Yoo YH, Choi YH.

Gen Physiol Biophys. 2017 Apr;36(2):117-128. doi: 10.4149/gpb_2016043. Epub 2017 Feb 20.


5, 7-Dimethoxyflavone sensitizes TRAIL-induced apoptosis through DR5 upregulation in hepatocellular carcinoma cells.

Yang JF, Cao JG, Tian L, Liu F.

Cancer Chemother Pharmacol. 2012 Jan;69(1):195-206. doi: 10.1007/s00280-011-1686-9. Epub 2011 Jun 10.


The flavonoid morin from Moraceae induces apoptosis by modulation of Bcl-2 family members and Fas receptor in HCT 116 cells.

Hyun HB, Lee WS, Go SI, Nagappan A, Park C, Han MH, Hong SH, Kim G, Kim GY, Cheong J, Ryu CH, Shin SC, Choi YH.

Int J Oncol. 2015;46(6):2670-8. doi: 10.3892/ijo.2015.2967. Epub 2015 Apr 16.


Supercritical carbon dioxide extraction of aromatic turmerone from Curcuma longa Linn. induces apoptosis through reactive oxygen species-triggered intrinsic and extrinsic pathways in human hepatocellular carcinoma HepG2 cells.

Cheng SB, Wu LC, Hsieh YC, Wu CH, Chan YJ, Chang LH, Chang CM, Hsu SL, Teng CL, Wu CC.

J Agric Food Chem. 2012 Sep 26;60(38):9620-30. Epub 2012 Sep 12.


Upregulation of Death Receptor 5 and Production of Reactive Oxygen Species Mediate Sensitization of PC-3 Prostate Cancer Cells to TRAIL Induced Apoptosis by Vitisin A.

Shin D, Kwon HY, Sohn EJ, Nam MS, Kim JH, Lee JC, Ryu SY, Park B, Kim SH.

Cell Physiol Biochem. 2015;36(3):1151-62. doi: 10.1159/000430286. Epub 2015 Jun 25.


Morin, a flavonoid from moraceae, induces apoptosis by induction of BAD protein in human leukemic cells.

Park C, Lee WS, Go SI, Nagappan A, Han MH, Hong SH, Kim GS, Kim GY, Kwon TK, Ryu CH, Shin SC, Choi YH.

Int J Mol Sci. 2014 Dec 30;16(1):645-59. doi: 10.3390/ijms16010645.


Enhancement of auranofin-induced lung cancer cell apoptosis by selenocystine, a natural inhibitor of TrxR1 in vitro and in vivo.

Fan C, Zheng W, Fu X, Li X, Wong YS, Chen T.

Cell Death Dis. 2014 Apr 24;5:e1191. doi: 10.1038/cddis.2014.132.


Hwang-Heuk-San induces apoptosis in HCT116 human colorectal cancer cells through the ROS-mediated activation of caspases and the inactivation of the PI3K/Akt signaling pathway.

Lee MH, Hong SH, Park C, Kim GY, Leem SH, Choi SH, Keum YS, Hyun JW, Kwon TK, Hong SH, Choi YH.

Oncol Rep. 2016 Jul;36(1):205-14. doi: 10.3892/or.2016.4812. Epub 2016 May 17.


Enhancement of auranofin-induced apoptosis in MCF-7 human breast cells by selenocystine, a synergistic inhibitor of thioredoxin reductase.

Liu C, Liu Z, Li M, Li X, Wong YS, Ngai SM, Zheng W, Zhang Y, Chen T.

PLoS One. 2013;8(1):e53945. doi: 10.1371/journal.pone.0053945. Epub 2013 Jan 14.


Morin Inhibits Proliferation of SW480 Colorectal Cancer Cells by Inducing Apoptosis Mediated by Reactive Oxygen Species Formation and Uncoupling of Warburg Effect.

Sithara T, Arun KB, Syama HP, Reshmitha TR, Nisha P.

Front Pharmacol. 2017 Sep 12;8:640. doi: 10.3389/fphar.2017.00640. eCollection 2017.


Casticin induces caspase-mediated apoptosis via activation of mitochondrial pathway and upregulation of DR5 in human lung cancer cells.

Zhou Y, Peng Y, Mao QQ, Li X, Chen MW, Su J, Tian L, Mao NQ, Long LZ, Quan MF, Liu F, Zhou SF, Zhao YX.

Asian Pac J Trop Med. 2013 May 13;6(5):372-8. doi: 10.1016/S1995-7645(13)60041-3.


TRAIL enhances apoptosis of human hepatocellular carcinoma cells sensitized by hepatitis C virus infection: therapeutic implications.

Jang JY, Kim SJ, Cho EK, Jeong SW, Park EJ, Lee WC, Lee SH, Kim SG, Kim YS, Kim HS, Kim BS, Lin W, Chung RT.

PLoS One. 2014 Jun 13;9(6):e98171. doi: 10.1371/journal.pone.0098171. eCollection 2014.


Hexane extracts of garlic cloves induce apoptosis through the generation of reactive oxygen species in Hep3B human hepatocarcinoma cells.

Kim HJ, Han MH, Kim GY, Choi YW, Choi YH.

Oncol Rep. 2012 Nov;28(5):1757-63. doi: 10.3892/or.2012.1985. Epub 2012 Aug 23.


Pachymic Acid Induces Apoptosis of EJ Bladder Cancer Cells by DR5 Up-Regulation, ROS Generation, Modulation of Bcl-2 and IAP Family Members.

Jeong JW, Lee WS, Go SI, Nagappan A, Baek JY, Lee JD, Lee SJ, Park C, Kim GY, Kim HJ, Kim GS, Kwon TK, Ryu CH, Shin SC, Choi YH.

Phytother Res. 2015 Oct;29(10):1516-24. doi: 10.1002/ptr.5402. Epub 2015 Jul 7.


Bufalin Induces Apoptotic Cell Death in Human Nasopharyngeal Carcinoma Cells through Mitochondrial ROS and TRAIL Pathways.

Su EY, Chu YL, Chueh FS, Ma YS, Peng SF, Huang WW, Liao CL, Huang AC, Chung JG.

Am J Chin Med. 2019;47(1):237-257. doi: 10.1142/S0192415X19500125. Epub 2019 Jan 7.


Camptothecin sensitizes human hepatoma Hep3B cells to TRAIL-mediated apoptosis via ROS-dependent death receptor 5 upregulation with the involvement of MAPKs.

Jayasooriya RG, Choi YH, Hyun JW, Kim GY.

Environ Toxicol Pharmacol. 2014 Nov;38(3):959-67. doi: 10.1016/j.etap.2014.10.012. Epub 2014 Oct 24.


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