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Items: 1 to 20 of 97

1.

TRAF6 directs FOXP3 localization and facilitates regulatory T-cell function through K63-linked ubiquitination.

Ni X, Kou W, Gu J, Wei P, Wu X, Peng H, Tao J, Yan W, Yang X, Lebid A, Park BV, Chen Z, Tian Y, Fu J, Newman S, Wang X, Shen H, Li B, Blazar BR, Wang X, Barbi J, Pan F, Lu L.

EMBO J. 2019 May 2;38(9). pii: e99766. doi: 10.15252/embj.201899766. Epub 2019 Mar 18.

2.

Induction of CD4+CD25+FOXP3+ regulatory T cells by mesenchymal stem cells is associated with modulation of ubiquitination factors and TSDR demethylation.

Khosravi M, Bidmeshkipour A, Cohen JL, Moravej A, Hojjat-Assari S, Naserian S, Karimi MH.

Stem Cell Res Ther. 2018 Oct 25;9(1):273. doi: 10.1186/s13287-018-0991-1.

3.

TRAF6 is essential for maintenance of regulatory T cells that suppress Th2 type autoimmunity.

Muto G, Kotani H, Kondo T, Morita R, Tsuruta S, Kobayashi T, Luche H, Fehling HJ, Walsh M, Choi Y, Yoshimura A.

PLoS One. 2013 Sep 13;8(9):e74639. doi: 10.1371/journal.pone.0074639. eCollection 2013.

4.

TRAF6 and the three C-terminal lysine sites on IRF7 are required for its ubiquitination-mediated activation by the tumor necrosis factor receptor family member latent membrane protein 1.

Ning S, Campos AD, Darnay BG, Bentz GL, Pagano JS.

Mol Cell Biol. 2008 Oct;28(20):6536-46. doi: 10.1128/MCB.00785-08. Epub 2008 Aug 18.

5.

Ring finger protein 31-mediated atypical ubiquitination stabilizes forkhead box P3 and thereby stimulates regulatory T-cell function.

Zhu F, Yi G, Liu X, Zhu F, Zhao A, Wang A, Zhu R, Chen Z, Zhao B, Fang S, Yu X, Lin R, Liang R, Li D, Zhao W, Zhang Z, Guo W, Zhang S, Ge S, Fan X, Zhao G, Li B.

J Biol Chem. 2018 Dec 28;293(52):20099-20111. doi: 10.1074/jbc.RA118.005802. Epub 2018 Nov 2.

PMID:
30389786
6.

Ubiquitin-dependent regulation of Foxp3 and Treg function.

Barbi J, Pardoll DM, Pan F.

Immunol Rev. 2015 Jul;266(1):27-45. doi: 10.1111/imr.12312. Review.

7.

TRAF6 directs commitment to regulatory T cells in thymocytes.

Shimo Y, Yanai H, Ohshima D, Qin J, Motegi H, Maruyama Y, Hori S, Inoue J, Akiyama T.

Genes Cells. 2011 Apr;16(4):437-47. doi: 10.1111/j.1365-2443.2011.01500.x. Epub 2011 Mar 15.

8.

TRAF6 Restricts p53 Mitochondrial Translocation, Apoptosis, and Tumor Suppression.

Zhang X, Li CF, Zhang L, Wu CY, Han L, Jin G, Rezaeian AH, Han F, Liu C, Xu C, Xu X, Huang CY, Tsai FJ, Tsai CH, Watabe K, Lin HK.

Mol Cell. 2016 Nov 17;64(4):803-814. doi: 10.1016/j.molcel.2016.10.002. Epub 2016 Nov 3.

9.

Presenilins are novel substrates for TRAF6-mediated ubiquitination.

Yan R, Farrelly S, McCarthy JV.

Cell Signal. 2013 Sep;25(9):1769-79. doi: 10.1016/j.cellsig.2013.05.015. Epub 2013 May 21.

PMID:
23707529
10.

Nemo-like Kinase Drives Foxp3 Stability and Is Critical for Maintenance of Immune Tolerance by Regulatory T Cells.

Fleskens V, Minutti CM, Wu X, Wei P, Pals CEGM, McCrae J, Hemmers S, Groenewold V, Vos HJ, Rudensky A, Pan F, Li H, Zaiss DM, Coffer PJ.

Cell Rep. 2019 Mar 26;26(13):3600-3612.e6. doi: 10.1016/j.celrep.2019.02.087.

11.

Site-specific Lys-63-linked tumor necrosis factor receptor-associated factor 6 auto-ubiquitination is a critical determinant of I kappa B kinase activation.

Lamothe B, Besse A, Campos AD, Webster WK, Wu H, Darnay BG.

J Biol Chem. 2007 Feb 9;282(6):4102-12. Epub 2006 Nov 29.

12.

Mammalian Sterile 20-like Kinase 1 (Mst1) Enhances the Stability of Forkhead Box P3 (Foxp3) and the Function of Regulatory T Cells by Modulating Foxp3 Acetylation.

Li J, Du X, Shi H, Deng K, Chi H, Tao W.

J Biol Chem. 2015 Dec 25;290(52):30762-70. doi: 10.1074/jbc.M115.668442. Epub 2015 Nov 3.

13.

Functional regulation of MyD88-activated interferon regulatory factor 5 by K63-linked polyubiquitination.

Balkhi MY, Fitzgerald KA, Pitha PM.

Mol Cell Biol. 2008 Dec;28(24):7296-308. doi: 10.1128/MCB.00662-08. Epub 2008 Sep 29.

14.

TARBP2 inhibits IRF7 activation by suppressing TRAF6-mediated K63-linked ubiquitination of IRF7.

Ling T, Weng GX, Li J, Li C, Wang W, Cao L, Rao H, Ju C, Xu LG.

Mol Immunol. 2019 May;109:116-125. doi: 10.1016/j.molimm.2019.02.019. Epub 2019 Mar 27.

PMID:
30927622
15.

Traf6 and A20 differentially regulate TLR4-induced autophagy by affecting the ubiquitination of Beclin 1.

Shi CS, Kehrl JH.

Autophagy. 2010 Oct;6(7):986-7. doi: 10.4161/auto.6.7.13288. Epub 2010 Oct 9.

16.

SKP2 loss destabilizes EZH2 by promoting TRAF6-mediated ubiquitination to suppress prostate cancer.

Lu W, Liu S, Li B, Xie Y, Izban MG, Ballard BR, Sathyanarayana SA, Adunyah SE, Matusik RJ, Chen Z.

Oncogene. 2017 Mar;36(10):1364-1373. doi: 10.1038/onc.2016.300. Epub 2016 Nov 21.

17.

Foxp3(+) T cells expressing RORγt represent a stable regulatory T-cell effector lineage with enhanced suppressive capacity during intestinal inflammation.

Yang BH, Hagemann S, Mamareli P, Lauer U, Hoffmann U, Beckstette M, Föhse L, Prinz I, Pezoldt J, Suerbaum S, Sparwasser T, Hamann A, Floess S, Huehn J, Lochner M.

Mucosal Immunol. 2016 Mar;9(2):444-57. doi: 10.1038/mi.2015.74. Epub 2015 Aug 26.

PMID:
26307665
18.

TRAF6 autoubiquitination-independent activation of the NFkappaB and MAPK pathways in response to IL-1 and RANKL.

Walsh MC, Kim GK, Maurizio PL, Molnar EE, Choi Y.

PLoS One. 2008;3(12):e4064. doi: 10.1371/journal.pone.0004064. Epub 2008 Dec 29.

19.

miR-146b antagomir-treated human Tregs acquire increased GVHD inhibitory potency.

Lu Y, Hippen KL, Lemire AL, Gu J, Wang W, Ni X, Ranganathan P, Levine BL, Riley JL, June CH, Turka LA, Munn DH, Garzon R, Lu L, Blazar BR.

Blood. 2016 Sep 8;128(10):1424-35. doi: 10.1182/blood-2016-05-714535. Epub 2016 Aug 2.

20.

FOXP3 promoter demethylation reveals the committed Treg population in humans.

Janson PC, Winerdal ME, Marits P, Thörn M, Ohlsson R, Winqvist O.

PLoS One. 2008 Feb 20;3(2):e1612. doi: 10.1371/journal.pone.0001612.

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