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Items: 1 to 20 of 98

1.

Identification of Novel Coumestan Derivatives as Polyketide Synthase 13 Inhibitors against Mycobacterium tuberculosis. Part II.

Zhang W, Lun S, Liu LL, Xiao S, Duan G, Gunosewoyo H, Yang F, Tang J, Bishai WR, Yu LF.

J Med Chem. 2019 Apr 11;62(7):3575-3589. doi: 10.1021/acs.jmedchem.9b00010. Epub 2019 Mar 27.

PMID:
30875203
2.

Identification of Novel Coumestan Derivatives as Polyketide Synthase 13 Inhibitors against Mycobacterium tuberculosis.

Zhang W, Lun S, Wang SH, Jiang XW, Yang F, Tang J, Manson AL, Earl AM, Gunosewoyo H, Bishai WR, Yu LF.

J Med Chem. 2018 Feb 8;61(3):791-803. doi: 10.1021/acs.jmedchem.7b01319. Epub 2018 Jan 29.

PMID:
29328655
3.

Development of a Novel Lead that Targets M. tuberculosis Polyketide Synthase 13.

Aggarwal A, Parai MK, Shetty N, Wallis D, Woolhiser L, Hastings C, Dutta NK, Galaviz S, Dhakal RC, Shrestha R, Wakabayashi S, Walpole C, Matthews D, Floyd D, Scullion P, Riley J, Epemolu O, Norval S, Snavely T, Robertson GT, Rubin EJ, Ioerger TR, Sirgel FA, van der Merwe R, van Helden PD, Keller P, Böttger EC, Karakousis PC, Lenaerts AJ, Sacchettini JC.

Cell. 2017 Jul 13;170(2):249-259.e25. doi: 10.1016/j.cell.2017.06.025. Epub 2017 Jun 29.

4.

Insights into an alternative benzofuran binding mode and novel scaffolds of polyketide synthase 13 inhibitors.

Çınaroğlu SS, Timuçin E.

J Mol Model. 2019 Apr 25;25(5):130. doi: 10.1007/s00894-019-4010-y.

PMID:
31025202
5.

Molecular dynamics simulation and binding free energy studies of novel leads belonging to the benzofuran class inhibitors of Mycobacterium tuberculosis Polyketide Synthase 13.

Cruz JN, Costa JFS, Khayat AS, Kuca K, Barros CAL, Neto AMJC.

J Biomol Struct Dyn. 2019 Apr;37(6):1616-1627. doi: 10.1080/07391102.2018.1462734. Epub 2018 May 4.

PMID:
29633908
6.

Benzofuran-isatin hybrids and their in vitro anti-mycobacterial activities against multi-drug resistant Mycobacterium tuberculosis.

Gao F, Ye L, Wang Y, Kong F, Zhao S, Xiao J, Huang G.

Eur J Med Chem. 2019 Sep 5;183:111678. doi: 10.1016/j.ejmech.2019.111678. [Epub ahead of print]

PMID:
31525660
7.

Development of ssDNA aptamers as potent inhibitors of Mycobacterium tuberculosis acetohydroxyacid synthase.

Baig IA, Moon JY, Lee SC, Ryoo SW, Yoon MY.

Biochim Biophys Acta. 2015 Oct;1854(10 Pt A):1338-50. doi: 10.1016/j.bbapap.2015.05.003. Epub 2015 May 16.

PMID:
25988243
8.

Naphthoquinones isolated from Diospyros anisandra exhibit potent activity against pan-resistant first-line drugs Mycobacterium tuberculosis strains.

Uc-Cachón AH, Borges-Argáez R, Said-Fernández S, Vargas-Villarreal J, González-Salazar F, Méndez-González M, Cáceres-Farfán M, Molina-Salinas GM.

Pulm Pharmacol Ther. 2014 Feb;27(1):114-20. doi: 10.1016/j.pupt.2013.08.001. Epub 2013 Aug 20.

PMID:
23968826
9.

Novel amide and sulphonamide derivatives of 6-(piperazin-1-yl)phenanthridine as potent Mycobacterium tuberculosis H37Rv inhibitors.

Naidu KM, Nagesh HN, Singh M, Sriram D, Yogeeswari P, Gowri Chandra Sekhar KV.

Eur J Med Chem. 2015 Mar 6;92:415-26. doi: 10.1016/j.ejmech.2015.01.013. Epub 2015 Jan 9.

PMID:
25590862
10.

Benzofuran-isatin hybrids tethered via different length alkyl linkers and their in vitro anti-mycobacterial activities.

Gao F, Chen Z, Ma L, Qiu L, Lin J, Lu G.

Bioorg Med Chem. 2019 Jun 15;27(12):2652-2656. doi: 10.1016/j.bmc.2019.04.017. Epub 2019 Apr 10.

PMID:
30992202
11.

Design, synthesis and investigation on the structure-activity relationships of N-substituted 2-aminothiazole derivatives as antitubercular agents.

Pieroni M, Wan B, Cho S, Franzblau SG, Costantino G.

Eur J Med Chem. 2014 Jan 24;72:26-34. doi: 10.1016/j.ejmech.2013.11.007. Epub 2013 Nov 13.

PMID:
24333612
12.

Synthesis and evaluation of new 2-aminothiophenes against Mycobacterium tuberculosis.

Thanna S, Knudson SE, Grzegorzewicz A, Kapil S, Goins CM, Ronning DR, Jackson M, Slayden RA, Sucheck SJ.

Org Biomol Chem. 2016 Jul 7;14(25):6119-6133. doi: 10.1039/c6ob00821f. Epub 2016 Jun 2.

13.

Identification and characterization of coumestans as novel HCV NS5B polymerase inhibitors.

Kaushik-Basu N, Bopda-Waffo A, Talele TT, Basu A, Costa PR, da Silva AJ, Sarafianos SG, Noël F.

Nucleic Acids Res. 2008 Mar;36(5):1482-96. doi: 10.1093/nar/gkm1178. Epub 2008 Jan 18.

14.

Discovery of novel 5-(ethyl or hydroxymethyl) analogs of 2'-'up' fluoro (or hydroxyl) pyrimidine nucleosides as a new class of Mycobacterium tuberculosis, Mycobacterium bovis and Mycobacterium avium inhibitors.

Shakya N, Srivastav NC, Bhavanam S, Tse C, Desroches N, Agrawal B, Kunimoto DY, Kumar R.

Bioorg Med Chem. 2012 Jul 1;20(13):4088-97. doi: 10.1016/j.bmc.2012.05.004. Epub 2012 May 15.

PMID:
22664188
15.

Screening of antitubercular compound library identifies novel ATP synthase inhibitors of Mycobacterium tuberculosis.

Kumar S, Mehra R, Sharma S, Bokolia NP, Raina D, Nargotra A, Singh PP, Khan IA.

Tuberculosis (Edinb). 2018 Jan;108:56-63. doi: 10.1016/j.tube.2017.10.008. Epub 2017 Oct 25.

PMID:
29523328
16.

Virtual Screening of potential drug-like inhibitors against Lysine/DAP pathway of Mycobacterium tuberculosis.

Garg A, Tewari R, Raghava GP.

BMC Bioinformatics. 2010 Jan 18;11 Suppl 1:S53. doi: 10.1186/1471-2105-11-S1-S53.

17.

New lipophilic isoniazid derivatives and their 1,3,4-oxadiazole analogues: Synthesis, antimycobacterial activity and investigation of their mechanism of action.

Vosátka R, Krátký M, Švarcová M, Janoušek J, Stolaříková J, Madacki J, Huszár S, Mikušová K, Korduláková J, Trejtnar F, Vinšová J.

Eur J Med Chem. 2018 May 10;151:824-835. doi: 10.1016/j.ejmech.2018.04.017. Epub 2018 Apr 10.

PMID:
29679902
18.

[Development of antituberculous drugs: current status and future prospects].

Tomioka H, Namba K.

Kekkaku. 2006 Dec;81(12):753-74. Review. Japanese.

PMID:
17240921
19.

In vitro efficacies, ADME, and pharmacokinetic properties of phenoxazine derivatives active against Mycobacterium tuberculosis.

Tanner L, Evans JC, Seldon R, Jordaan A, Warner DF, Haynes RK, Parkinson CJ, Wiesner L.

Antimicrob Agents Chemother. 2019 Aug 19. pii: AAC.01010-19. doi: 10.1128/AAC.01010-19. [Epub ahead of print]

PMID:
31427302
20.

Triclosan derivatives: towards potent inhibitors of drug-sensitive and drug-resistant Mycobacterium tuberculosis.

Freundlich JS, Wang F, Vilchèze C, Gulten G, Langley R, Schiehser GA, Jacobus DP, Jacobs WR Jr, Sacchettini JC.

ChemMedChem. 2009 Feb;4(2):241-8. doi: 10.1002/cmdc.200800261.

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