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Items: 1 to 20 of 65

1.

GPER Mediates a Feedforward FGF2/FGFR1 Paracrine Activation Coupling CAFs to Cancer Cells toward Breast Tumor Progression.

Santolla MF, Vivacqua A, Lappano R, Rigiracciolo DC, Cirillo F, Galli GR, Talia M, Brunetti G, Miglietta AM, Belfiore A, Maggiolini M.

Cells. 2019 Mar 7;8(3). pii: E223. doi: 10.3390/cells8030223.

2.

Dynamic monitoring of GPER-mediated estrogenic effects in breast cancer associated fibroblasts: An alternative role of estrogen in mammary carcinoma development.

Luo H, Liu M, Luo S, Yu T, Wu C, Yang G, Tu G.

Steroids. 2016 Aug;112:1-11. doi: 10.1016/j.steroids.2016.03.013. Epub 2016 Mar 23.

PMID:
27016131
3.

GPER in CAFs regulates hypoxia-driven breast cancer invasion in a CTGF-dependent manner.

Ren J, Guo H, Wu H, Tian T, Dong D, Zhang Y, Sui Y, Zhang Y, Zhao D, Wang S, Li Z, Zhang X, Liu R, Qian J, Wei H, Jiang W, Liu Y, Li Y.

Oncol Rep. 2015 Apr;33(4):1929-37. doi: 10.3892/or.2015.3779. Epub 2015 Feb 3.

PMID:
25647524
4.

miR-338-3p Is Regulated by Estrogens through GPER in Breast Cancer Cells and Cancer-Associated Fibroblasts (CAFs).

Vivacqua A, Sebastiani A, Miglietta AM, Rigiracciolo DC, Cirillo F, Galli GR, Talia M, Santolla MF, Lappano R, Giordano F, Panno ML, Maggiolini M.

Cells. 2018 Nov 9;7(11). pii: E203. doi: 10.3390/cells7110203.

5.

AHR and GPER mediate the stimulatory effects induced by 3-methylcholanthrene in breast cancer cells and cancer-associated fibroblasts (CAFs).

Cirillo F, Lappano R, Bruno L, Rizzuti B, Grande F, Guzzi R, Briguori S, Miglietta AM, Nakajima M, Di Martino MT, Maggiolini M.

J Exp Clin Cancer Res. 2019 Aug 1;38(1):335. doi: 10.1186/s13046-019-1337-2.

6.

GPER mediates enhanced cell viability and motility via non-genomic signaling induced by 17β-estradiol in triple-negative breast cancer cells.

Yu T, Liu M, Luo H, Wu C, Tang X, Tang S, Hu P, Yan Y, Wang Z, Tu G.

J Steroid Biochem Mol Biol. 2014 Sep;143:392-403. doi: 10.1016/j.jsbmb.2014.05.003. Epub 2014 May 27.

PMID:
24874276
7.

The nuclear localization signal is required for nuclear GPER translocation and function in breast Cancer-Associated Fibroblasts (CAFs).

Pupo M, Vivacqua A, Perrotta I, Pisano A, Aquila S, Abonante S, Gasperi-Campani A, Pezzi V, Maggiolini M.

Mol Cell Endocrinol. 2013 Aug 25;376(1-2):23-32. doi: 10.1016/j.mce.2013.05.023. Epub 2013 Jun 5.

PMID:
23748028
8.
9.

GPER, IGF-IR, and EGFR transduction signaling are involved in stimulatory effects of zinc in breast cancer cells and cancer-associated fibroblasts.

Pisano A, Santolla MF, De Francesco EM, De Marco P, Rigiracciolo DC, Perri MG, Vivacqua A, Abonante S, Cappello AR, Dolce V, Belfiore A, Maggiolini M, Lappano R.

Mol Carcinog. 2017 Feb;56(2):580-593. doi: 10.1002/mc.22518. Epub 2016 Jul 4.

PMID:
27341075
10.

GPER is involved in the regulation of the estrogen-metabolizing CYP1B1 enzyme in breast cancer.

Cirillo F, Pellegrino M, Malivindi R, Rago V, Avino S, Muto L, Dolce V, Vivacqua A, Rigiracciolo DC, De Marco P, Sebastiani A, Abonante S, Nakajima M, Lappano R, Maggiolini M.

Oncotarget. 2017 Nov 20;8(63):106608-106624. doi: 10.18632/oncotarget.22541. eCollection 2017 Dec 5.

11.

GPER is involved in the functional liaison between breast tumor cells and cancer-associated fibroblasts (CAFs).

Lappano R, Maggiolini M.

J Steroid Biochem Mol Biol. 2018 Feb;176:49-56. doi: 10.1016/j.jsbmb.2017.02.019. Epub 2017 Feb 27. Review.

PMID:
28249728
12.

Low prognostic implication of fibroblast growth factor family activation in triple-negative breast cancer subsets.

Lee HJ, Seo AN, Park SY, Kim JY, Park JY, Yu JH, Ahn JH, Gong G.

Ann Surg Oncol. 2014 May;21(5):1561-8. doi: 10.1245/s10434-013-3456-x. Epub 2014 Jan 3.

PMID:
24385208
13.

miR-221 stimulates breast cancer cells and cancer-associated fibroblasts (CAFs) through selective interference with the A20/c-Rel/CTGF signaling.

Santolla MF, Lappano R, Cirillo F, Rigiracciolo DC, Sebastiani A, Abonante S, Tassone P, Tagliaferri P, Di Martino MT, Maggiolini M, Vivacqua A.

J Exp Clin Cancer Res. 2018 May 2;37(1):94. doi: 10.1186/s13046-018-0767-6.

14.

G protein-coupled estrogen receptor mediates the up-regulation of fatty acid synthase induced by 17β-estradiol in cancer cells and cancer-associated fibroblasts.

Santolla MF, Lappano R, De Marco P, Pupo M, Vivacqua A, Sisci D, Abonante S, Iacopetta D, Cappello AR, Dolce V, Maggiolini M.

J Biol Chem. 2012 Dec 21;287(52):43234-45. doi: 10.1074/jbc.M112.417303. Epub 2012 Nov 7.

15.

GPER signalling in both cancer-associated fibroblasts and breast cancer cells mediates a feedforward IL1β/IL1R1 response.

De Marco P, Lappano R, De Francesco EM, Cirillo F, Pupo M, Avino S, Vivacqua A, Abonante S, Picard D, Maggiolini M.

Sci Rep. 2016 Apr 13;6:24354. doi: 10.1038/srep24354.

16.

Effects of atrazine on estrogen receptor α- and G protein-coupled receptor 30-mediated signaling and proliferation in cancer cells and cancer-associated fibroblasts.

Albanito L, Lappano R, Madeo A, Chimento A, Prossnitz ER, Cappello AR, Dolce V, Abonante S, Pezzi V, Maggiolini M.

Environ Health Perspect. 2015 May;123(5):493-9. doi: 10.1289/ehp.1408586. Epub 2015 Jan 16.

17.

Inhibition of growth hormone receptor by Somavert reduces expression of GPER and prevents growth stimulation of triple-negative breast cancer by 17β-estradiol.

Girgert R, Emons G, Gründker C.

Oncol Lett. 2018 Jun;15(6):9559-9566. doi: 10.3892/ol.2018.8521. Epub 2018 Apr 18.

18.

Targeting the heparin-binding domain of fibroblast growth factor receptor 1 as a potential cancer therapy.

Ling L, Tan SK, Goh TH, Cheung E, Nurcombe V, van Wijnen AJ, Cool SM.

Mol Cancer. 2015 Jul 23;14:136. doi: 10.1186/s12943-015-0391-4.

19.

TNFAIP3 is required for FGFR1 activation-promoted proliferation and tumorigenesis of premalignant DCIS.COM human mammary epithelial cells.

Yang M, Yu X, Li X, Luo B, Yang W, Lin Y, Li D, Gan Z, Xu J, He T.

Breast Cancer Res. 2018 Aug 15;20(1):97. doi: 10.1186/s13058-018-1024-9.

20.

FGFR inhibitors: Effects on cancer cells, tumor microenvironment and whole-body homeostasis (Review).

Katoh M.

Int J Mol Med. 2016 Jul;38(1):3-15. doi: 10.3892/ijmm.2016.2620. Epub 2016 May 31. Review.

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