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Determination of Optimal Diagnostic Cut-Offs for the Naval Medical Research Center Scrub Typhus IgM ELISA in Chiang Rai, Thailand.

Phanichkrivalkosil M, Tanganuchitcharnchai A, Jintaworn S, Kantipong P, Laongnualpanich A, Chierakul W, Paris DH, Richards AL, Wangrangsimakul T, Day NPJ, Blacksell SD.

Am J Trop Med Hyg. 2019 May;100(5):1134-1140. doi: 10.4269/ajtmh.18-0675.


Optimal Cutoff and Accuracy of an IgM Enzyme-Linked Immunosorbent Assay for Diagnosis of Acute Scrub Typhus in Northern Thailand: an Alternative Reference Method to the IgM Immunofluorescence Assay.

Blacksell SD, Lim C, Tanganuchitcharnchai A, Jintaworn S, Kantipong P, Richards AL, Paris DH, Limmathurotsakul D, Day NPJ.

J Clin Microbiol. 2016 Jun;54(6):1472-1478. doi: 10.1128/JCM.02744-15. Epub 2016 Mar 23.


Diagnostic Accuracy of the InBios Scrub Typhus Detect Enzyme-Linked Immunoassay for the Detection of IgM Antibodies in Northern Thailand.

Blacksell SD, Tanganuchitcharnchai A, Nawtaisong P, Kantipong P, Laongnualpanich A, Day NP, Paris DH.

Clin Vaccine Immunol. 2015 Dec 9;23(2):148-54. doi: 10.1128/CVI.00553-15. Print 2016 Feb.


Diagnostic Accuracy of the InBios Scrub Typhus Detectâ„¢ ELISA for the Detection of IgM Antibodies in Chittagong, Bangladesh.

Blacksell SD, Kingston HWF, Tanganuchitcharnchai A, Phanichkrivalkosil M, Hossain M, Hossain A, Ghose A, Leopold SJ, Dondorp AM, Day NPJ, Paris DH.

Trop Med Infect Dis. 2018 Sep 1;3(3). pii: E95. doi: 10.3390/tropicalmed3030095.


Determination of Cutoff of ELISA and Immunofluorescence Assay for Scrub Typhus.

Gupta N, Chaudhry R, Thakur CK.

J Glob Infect Dis. 2016 Jul-Sep;8(3):97-9. doi: 10.4103/0974-777X.188584.


Prospective evaluation of commercial antibody-based rapid tests in combination with a loop-mediated isothermal amplification PCR assay for detection of Orientia tsutsugamushi during the acute phase of scrub typhus infection.

Blacksell SD, Paris DH, Chierakul W, Wuthiekanun V, Teeratakul A, Kantipong P, Day NP.

Clin Vaccine Immunol. 2012 Mar;19(3):391-5. doi: 10.1128/CVI.05478-11. Epub 2012 Jan 4.


Diagnostic performance of serological tests to detect antibodies against acute scrub typhus infection in central India.

Pote K, Narang R, Deshmukh P.

Indian J Med Microbiol. 2018 Jan-Mar;36(1):108-112. doi: 10.4103/ijmm.IJMM_17_405.


An ELISA assay using a combination of recombinant proteins from multiple strains of Orientia tsutsugamushi offers an accurate diagnosis for scrub typhus.

Chao CC, Zhang Z, Belinskaya T, Thipmontree W, Tantibhedyangkul W, Silpasakorn S, Wongsawat E, Suputtamongkol Y, Ching WM.

BMC Infect Dis. 2017 Jun 10;17(1):413. doi: 10.1186/s12879-017-2512-8.


Diagnostic accuracy of a loop-mediated isothermal PCR assay for detection of Orientia tsutsugamushi during acute Scrub Typhus infection.

Paris DH, Blacksell SD, Nawtaisong P, Jenjaroen K, Teeraratkul A, Chierakul W, Wuthiekanun V, Kantipong P, Day NP.

PLoS Negl Trop Dis. 2011 Sep;5(9):e1307. doi: 10.1371/journal.pntd.0001307. Epub 2011 Sep 13.


How to Determine the Accuracy of an Alternative Diagnostic Test when It Is Actually Better than the Reference Tests: A Re-Evaluation of Diagnostic Tests for Scrub Typhus Using Bayesian LCMs.

Lim C, Paris DH, Blacksell SD, Laongnualpanich A, Kantipong P, Chierakul W, Wuthiekanun V, Day NP, Cooper BS, Limmathurotsakul D.

PLoS One. 2015 May 29;10(5):e0114930. doi: 10.1371/journal.pone.0114930. eCollection 2015.


Clinical Characteristics and Outcome of Children Hospitalized With Scrub Typhus in an Area of Endemicity.

Wangrangsimakul T, Greer RC, Chanta C, Nedsuwan S, Blacksell SD, Day NPJ, Paris DH.

J Pediatric Infect Dis Soc. 2019 Mar 13. pii: piz014. doi: 10.1093/jpids/piz014. [Epub ahead of print]


The validity of diagnostic cut-offs for commercial and in-house scrub typhus IgM and IgG ELISAs: A review of the evidence.

Saraswati K, Phanichkrivalkosil M, Day NPJ, Blacksell SD.

PLoS Negl Trop Dis. 2019 Feb 4;13(2):e0007158. doi: 10.1371/journal.pntd.0007158. eCollection 2019 Feb.


Diagnostic validation of selected serological tests for detecting scrub typhus.

Koraluru M, Bairy I, Varma M, Vidyasagar S.

Microbiol Immunol. 2015 Jul;59(7):371-4. doi: 10.1111/1348-0421.12268.


Improving the Diagnosis of Scrub Typhus by Combining groEL Based Polymerase Chain Reaction and IgM ELISA.

Patricia KA, Hoti SL, Kanungo R, Jambulingam P, Shashikala N, Naik AC.

J Clin Diagn Res. 2017 Aug;11(8):DC27-DC31. doi: 10.7860/JCDR/2017/26523.10519. Epub 2017 Aug 1.


Acute undifferentiated fever in India: a multicentre study of aetiology and diagnostic accuracy.

Mørch K, Manoharan A, Chandy S, Chacko N, Alvarez-Uria G, Patil S, Henry A, Nesaraj J, Kuriakose C, Singh A, Kurian S, Gill Haanshuus C, Langeland N, Blomberg B, Vasanthan Antony G, Mathai D.

BMC Infect Dis. 2017 Oct 4;17(1):665. doi: 10.1186/s12879-017-2764-3.


Serodiagnosis of Scrub Typhus at a Tertiary Care Hospital from Southern India.

Roopa KS, Karthika K, Sugumar M, Bammigatti C, Shamanna SB, Harish BN.

J Clin Diagn Res. 2015 Nov;9(11):DC05-7. doi: 10.7860/JCDR/2015/15871.6759. Epub 2015 Nov 1.


Rapid diagnosis of scrub typhus in rural Thailand using polymerase chain reaction.

Sonthayanon P, Chierakul W, Wuthiekanun V, Blacksell SD, Pimda K, Suputtamongkol Y, Pukrittayakamee S, White NJ, Day NP, Peacock SJ.

Am J Trop Med Hyg. 2006 Dec;75(6):1099-102.


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