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Items: 1 to 20 of 107

1.

Telomere elongation via alternative lengthening of telomeres (ALT) and telomerase activation in primary metastatic medulloblastoma of childhood.

Minasi S, Baldi C, Pietsch T, Donofrio V, Pollo B, Antonelli M, Massimino M, Giangaspero F, Buttarelli FR.

J Neurooncol. 2019 May;142(3):435-444. doi: 10.1007/s11060-019-03127-w. Epub 2019 Mar 4.

PMID:
30830680
2.

Alternative lengthening of telomeres phenotype in malignant vascular tumors is highly associated with loss of ATRX expression and is frequently observed in hepatic angiosarcomas.

Liau JY, Tsai JH, Yang CY, Lee JC, Liang CW, Hsu HH, Jeng YM.

Hum Pathol. 2015 Sep;46(9):1360-6. doi: 10.1016/j.humpath.2015.05.019. Epub 2015 Jun 5.

PMID:
26190196
3.

TERT Promoter Mutations but not the Alternative Lengthening of Telomeres Phenotype Are Present in a Subset of Ependymomas and Are Associated With Adult Onset and Progression to Ependymosarcoma.

Brügger F, Dettmer MS, Neuenschwander M, Perren A, Marinoni I, Hewer E.

J Neuropathol Exp Neurol. 2017 Jan 1;76(1):61-66. doi: 10.1093/jnen/nlw106.

PMID:
28040793
4.

Leiomyosarcoma with alternative lengthening of telomeres is associated with aggressive histologic features, loss of ATRX expression, and poor clinical outcome.

Liau JY, Tsai JH, Jeng YM, Lee JC, Hsu HH, Yang CY.

Am J Surg Pathol. 2015 Feb;39(2):236-44. doi: 10.1097/PAS.0000000000000324.

PMID:
25229770
5.

Loss of wild-type ATRX expression in somatic cell hybrids segregates with activation of Alternative Lengthening of Telomeres.

Bower K, Napier CE, Cole SL, Dagg RA, Lau LM, Duncan EL, Moy EL, Reddel RR.

PLoS One. 2012;7(11):e50062. doi: 10.1371/journal.pone.0050062. Epub 2012 Nov 20.

6.

ATRX represses alternative lengthening of telomeres.

Napier CE, Huschtscha LI, Harvey A, Bower K, Noble JR, Hendrickson EA, Reddel RR.

Oncotarget. 2015 Jun 30;6(18):16543-58.

7.

Telomerase Activation and ATRX Mutations Are Independent Risk Factors for Metastatic Pheochromocytoma and Paraganglioma.

Job S, Draskovic I, Burnichon N, Buffet A, Cros J, Lépine C, Venisse A, Robidel E, Verkarre V, Meatchi T, Sibony M, Amar L, Bertherat J, de Reyniès A, Londoño-Vallejo A, Favier J, Castro-Vega LJ, Gimenez-Roqueplo AP.

Clin Cancer Res. 2019 Jan 15;25(2):760-770. doi: 10.1158/1078-0432.CCR-18-0139. Epub 2018 Oct 9.

PMID:
30301828
8.

ATRX loss induces multiple hallmarks of the alternative lengthening of telomeres (ALT) phenotype in human glioma cell lines in a cell line-specific manner.

Brosnan-Cashman JA, Yuan M, Graham MK, Rizzo AJ, Myers KM, Davis C, Zhang R, Esopi DM, Raabe EH, Eberhart CG, Heaphy CM, Meeker AK.

PLoS One. 2018 Sep 18;13(9):e0204159. doi: 10.1371/journal.pone.0204159. eCollection 2018.

9.

Alternative lengthening of telomeres and loss of ATRX are frequent events in pleomorphic and dedifferentiated liposarcomas.

Lee JC, Jeng YM, Liau JY, Tsai JH, Hsu HH, Yang CY.

Mod Pathol. 2015 Aug;28(8):1064-73. doi: 10.1038/modpathol.2015.67. Epub 2015 May 29.

10.

DNA methylation mediated up-regulation of TERRA non-coding RNA is coincident with elongated telomeres in the human placenta.

Novakovic B, Napier CE, Vryer R, Dimitriadis E, Manuelpillai U, Sharkey A, Craig JM, Reddel RR, Saffery R.

Mol Hum Reprod. 2016 Nov;22(11):791-799. Epub 2016 Sep 7.

PMID:
27604461
11.

Alternative Lengthening of Telomeres and Loss of DAXX/ATRX Expression Predicts Metastatic Disease and Poor Survival in Patients with Pancreatic Neuroendocrine Tumors.

Singhi AD, Liu TC, Roncaioli JL, Cao D, Zeh HJ, Zureikat AH, Tsung A, Marsh JW, Lee KK, Hogg ME, Bahary N, Brand RE, McGrath KM, Slivka A, Cressman KL, Fuhrer K, O'Sullivan RJ.

Clin Cancer Res. 2017 Jan 15;23(2):600-609. doi: 10.1158/1078-0432.CCR-16-1113. Epub 2016 Jul 12.

12.

Alternative lengthening of telomeres, ATRX loss and H3-K27M mutations in histologically defined pilocytic astrocytoma with anaplasia.

Rodriguez FJ, Brosnan-Cashman JA, Allen SJ, Vizcaino MA, Giannini C, Camelo-Piragua S, Webb M, Matsushita M, Wadhwani N, Tabbarah A, Hamideh D, Jiang L, Chen L, Arvanitis LD, Alnajar HH, Barber JR, Rodríguez-Velasco A, Orr B, Heaphy CM.

Brain Pathol. 2019 Jan;29(1):126-140. doi: 10.1111/bpa.12646. Epub 2018 Oct 17.

PMID:
30192422
13.

The role of histone modifications and telomere alterations in the pathogenesis of diffuse gliomas in adults and children.

Lee J, Solomon DA, Tihan T.

J Neurooncol. 2017 Mar;132(1):1-11. doi: 10.1007/s11060-016-2349-9. Epub 2017 Jan 7. Review. Erratum in: J Neurooncol. 2017 Mar;132(1):13.

14.

Alternative Lengthening of Telomeres is characterized by reduced compaction of telomeric chromatin.

Episkopou H, Draskovic I, Van Beneden A, Tilman G, Mattiussi M, Gobin M, Arnoult N, Londoño-Vallejo A, Decottignies A.

Nucleic Acids Res. 2014 Apr;42(7):4391-405. doi: 10.1093/nar/gku114. Epub 2014 Feb 5.

15.

Targeting Telomerase and ATRX/DAXX Inducing Tumor Senescence and Apoptosis in the Malignant Glioma.

Fan HC, Chen CM, Chi CS, Tsai JD, Chiang KL, Chang YK, Lin SZ, Harn HJ.

Int J Mol Sci. 2019 Jan 8;20(1). pii: E200. doi: 10.3390/ijms20010200. Review.

16.

Alternative lengthening of telomeres (ALT) and chromatin: is there a connection?

Nittis T, Guittat L, Stewart SA.

Biochimie. 2008 Jan;90(1):5-12. Epub 2007 Sep 2. Review.

PMID:
17935854
17.

Alternative lengthening of telomeres and ATRX/DAXX loss can be reliably detected in FNAs of pancreatic neuroendocrine tumors.

VandenBussche CJ, Allison DB, Graham MK, Charu V, Lennon AM, Wolfgang CL, Hruban RH, Heaphy CM.

Cancer Cytopathol. 2017 Jul;125(7):544-551. doi: 10.1002/cncy.21857. Epub 2017 Apr 3.

18.

Telomere biology including TERT rearrangements in neuroblastoma: a useful indicator for surgical treatments.

Kawashima M, Kojima M, Ueda Y, Kurihara S, Hiyama E.

J Pediatr Surg. 2016 Dec;51(12):2080-2085. doi: 10.1016/j.jpedsurg.2016.09.042. Epub 2016 Sep 17.

PMID:
27793328
19.

TERT promoter mutations occur frequently in gliomas and a subset of tumors derived from cells with low rates of self-renewal.

Killela PJ, Reitman ZJ, Jiao Y, Bettegowda C, Agrawal N, Diaz LA Jr, Friedman AH, Friedman H, Gallia GL, Giovanella BC, Grollman AP, He TC, He Y, Hruban RH, Jallo GI, Mandahl N, Meeker AK, Mertens F, Netto GJ, Rasheed BA, Riggins GJ, Rosenquist TA, Schiffman M, Shih IeM, Theodorescu D, Torbenson MS, Velculescu VE, Wang TL, Wentzensen N, Wood LD, Zhang M, McLendon RE, Bigner DD, Kinzler KW, Vogelstein B, Papadopoulos N, Yan H.

Proc Natl Acad Sci U S A. 2013 Apr 9;110(15):6021-6. doi: 10.1073/pnas.1303607110. Epub 2013 Mar 25.

20.

Switch telomerase to ALT mechanism by inducing telomeric DNA damages and dysfunction of ATRX and DAXX.

Hu Y, Shi G, Zhang L, Li F, Jiang Y, Jiang S, Ma W, Zhao Y, Songyang Z, Huang J.

Sci Rep. 2016 Aug 31;6:32280. doi: 10.1038/srep32280.

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