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Items: 1 to 20 of 96

1.

Brain metabolism modulates neuronal excitability in a mouse model of pyruvate dehydrogenase deficiency.

Jakkamsetti V, Marin-Valencia I, Ma Q, Good LB, Terrill T, Rajasekaran K, Pichumani K, Khemtong C, Hooshyar MA, Sundarrajan C, Patel MS, Bachoo RM, Malloy CR, Pascual JM.

Sci Transl Med. 2019 Feb 20;11(480). pii: eaan0457. doi: 10.1126/scitranslmed.aan0457.

PMID:
30787166
2.
3.
4.

Cardiolipin-induced activation of pyruvate dehydrogenase links mitochondrial lipid biosynthesis to TCA cycle function.

Li Y, Lou W, Raja V, Denis S, Yu W, Schmidtke MW, Reynolds CA, Schlame M, Houtkooper RH, Greenberg ML.

J Biol Chem. 2019 Jul 26;294(30):11568-11578. doi: 10.1074/jbc.RA119.009037. Epub 2019 Jun 11.

PMID:
31186346
5.

In vivo metabolic flux profiling with stable isotopes discriminates sites and quantifies effects of mitochondrial dysfunction in C. elegans.

Vergano SS, Rao M, McCormack S, Ostrovsky J, Clarke C, Preston J, Bennett MJ, Yudkoff M, Xiao R, Falk MJ.

Mol Genet Metab. 2014 Mar;111(3):331-341. doi: 10.1016/j.ymgme.2013.12.011. Epub 2013 Dec 27.

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7.

Dysfunctional TCA-Cycle Metabolism in Glutamate Dehydrogenase Deficient Astrocytes.

Nissen JD, Pajęcka K, Stridh MH, Skytt DM, Waagepetersen HS.

Glia. 2015 Dec;63(12):2313-26. doi: 10.1002/glia.22895. Epub 2015 Jul 29.

PMID:
26221781
8.

Glut1 deficiency (G1D): epilepsy and metabolic dysfunction in a mouse model of the most common human phenotype.

Marin-Valencia I, Good LB, Ma Q, Duarte J, Bottiglieri T, Sinton CM, Heilig CW, Pascual JM.

Neurobiol Dis. 2012 Oct;48(1):92-101. doi: 10.1016/j.nbd.2012.04.011. Epub 2012 Apr 23.

9.

Astrocytic energy metabolism and glutamate formation--relevance for 13C-NMR spectroscopy and importance of cytosolic/mitochondrial trafficking.

Hertz L.

Magn Reson Imaging. 2011 Dec;29(10):1319-29. doi: 10.1016/j.mri.2011.04.013. Epub 2011 Aug 5.

PMID:
21820830
11.

Probing the cardiac malate-aspartate shuttle non-invasively using hyperpolarized [1,2-13 C2 ]pyruvate.

Chen AP, Lau AZ, Gu YP, Schroeder MA, Barry J, Cunningham CH.

NMR Biomed. 2018 Jan;31(1). doi: 10.1002/nbm.3845. Epub 2017 Nov 6.

PMID:
29106770
12.

Cortical metabolism in pyruvate dehydrogenase deficiency revealed by ex vivo multiplet (13)C NMR of the adult mouse brain.

Marin-Valencia I, Good LB, Ma Q, Malloy CR, Patel MS, Pascual JM.

Neurochem Int. 2012 Dec;61(7):1036-43. doi: 10.1016/j.neuint.2012.07.020. Epub 2012 Aug 3.

13.

Repeated tetanic stimulation in piriform cortex in vitro: epileptogenesis and pharmacology.

Pelletier MR, Carlen PL.

J Neurophysiol. 1996 Dec;76(6):4069-79.

PMID:
8985901
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16.

Erk regulation of pyruvate dehydrogenase flux through PDK4 modulates cell proliferation.

Grassian AR, Metallo CM, Coloff JL, Stephanopoulos G, Brugge JS.

Genes Dev. 2011 Aug 15;25(16):1716-33. doi: 10.1101/gad.16771811.

17.

Pyruvate dehydrogenase complex deficiency and its relationship with epilepsy frequency--An overview.

Bhandary S, Aguan K.

Epilepsy Res. 2015 Oct;116:40-52. doi: 10.1016/j.eplepsyres.2015.07.002. Epub 2015 Jul 8. Review.

PMID:
26354166
18.

Integration between Glycolysis and Glutamate-Glutamine Cycle Flux May Explain Preferential Glycolytic Increase during Brain Activation, Requiring Glutamate.

Hertz L, Chen Y.

Front Integr Neurosci. 2017 Aug 25;11:18. doi: 10.3389/fnint.2017.00018. eCollection 2017. Review.

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