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Items: 1 to 20 of 105

1.

In vitro modulation of multidrug resistance by pregnane steroids and in vivo inhibition of tumour development by 7α-OBz-11α(R)-OTHP-5β-pregnanedione in K562/R7 and H295R cell xenografts.

Alameh G, Emptoz-Bonneton A, Rolland de Ravel M, Matera EL, Mappus E, Balaguer P, Rocheblave L, Lomberget T, Dumontet C, Le Borgne M, Pugeat M, Grenot C, Cuilleron CY.

J Enzyme Inhib Med Chem. 2019 Dec;34(1):684-691. doi: 10.1080/14756366.2019.1575825.

2.

Synthesis of new steroidal inhibitors of P-glycoprotein-mediated multidrug resistance and biological evaluation on K562/R7 erythroleukemia cells.

de Ravel MR, Alameh G, Melikian M, Mahiout Z, Emptoz-Bonneton A, Matera EL, Lomberget T, Barret R, Rocheblave L, Walchshofer N, Beltran S, El Jawad L, Mappus E, Grenot C, Pugeat M, Dumontet C, Le Borgne M, Cuilleron CY.

J Med Chem. 2015 Feb 26;58(4):1832-45. doi: 10.1021/jm501676v. Epub 2015 Feb 11.

PMID:
25634041
3.

Sensitization of multidrug-resistant malignant cells by liposomes co-encapsulating doxorubicin and chloroquine through autophagic inhibition.

Gao M, Xu Y, Qiu L.

J Liposome Res. 2017 Jun;27(2):151-160. doi: 10.1080/08982104.2016.1185731. Epub 2016 Jun 2.

PMID:
27250110
4.

Design and synthesis of new potent N,N-bis(arylalkyl)piperazine derivatives as multidrug resistance (MDR) reversing agents.

Dei S, Coronnello M, Bartolucci G, Manetti D, Romanelli MN, Udomtanakunchai C, Salerno M, Teodori E.

Eur J Med Chem. 2018 Mar 10;147:7-20. doi: 10.1016/j.ejmech.2018.01.092. Epub 2018 Feb 5.

PMID:
29421572
5.

A novel curcumin derivative which inhibits P-glycoprotein, arrests cell cycle and induces apoptosis in multidrug resistance cells.

Lopes-Rodrigues V, Oliveira A, Correia-da-Silva M, Pinto M, Lima RT, Sousa E, Vasconcelos MH.

Bioorg Med Chem. 2017 Jan 15;25(2):581-596. doi: 10.1016/j.bmc.2016.11.023. Epub 2016 Nov 19.

PMID:
27908756
6.

In vitro and in vivo reversal of P-glycoprotein-mediated multidrug resistance by a novel potent modulator, XR9576.

Mistry P, Stewart AJ, Dangerfield W, Okiji S, Liddle C, Bootle D, Plumb JA, Templeton D, Charlton P.

Cancer Res. 2001 Jan 15;61(2):749-58.

7.

Modulation of P-glycoprotein-mediated multidrug resistance in K562 leukemic cells by indole-3-carbinol.

Arora A, Seth K, Kalra N, Shukla Y.

Toxicol Appl Pharmacol. 2005 Feb 1;202(3):237-43.

PMID:
15667829
8.

Substituted tetrahydroisoquinoline compound B3 inhibited P-glycoprotein-mediated multidrug resistance in-vitro and in-vivo.

Fang W, Li Y, Cai Y, Kang K, Yan F, Liu G, Huang W.

J Pharm Pharmacol. 2007 Dec;59(12):1649-55.

PMID:
18053326
9.

Chemosensitizing effects of synthetic curcumin analogs on human multi-drug resistance leukemic cells.

Mapoung S, Pitchakarn P, Yodkeeree S, Ovatlarnporn C, Sakorn N, Limtrakul P.

Chem Biol Interact. 2016 Jan 25;244:140-8. doi: 10.1016/j.cbi.2015.12.001. Epub 2015 Dec 13.

PMID:
26689174
10.

Quercetin-glutamic acid conjugate with a non-hydrolysable linker; a novel scaffold for multidrug resistance reversal agents through inhibition of P-glycoprotein.

Kim MK, Kim Y, Choo H, Chong Y.

Bioorg Med Chem. 2017 Feb 1;25(3):1219-1226. doi: 10.1016/j.bmc.2016.12.034. Epub 2016 Dec 23.

PMID:
28043777
11.

Antitumor activity of troxacitabine (Troxatyl) against anthracycline-resistant human xenografts.

Gourdeau H, Genne P, Kadhim S, Bibeau L, Duchamp O, Ouellet F, deMuys JM, Bouffard DY, Attardo G.

Cancer Chemother Pharmacol. 2002 Dec;50(6):490-6. Epub 2002 Oct 16.

PMID:
12451476
12.

Schiff base derived from thiosemicarbazone and anthracene showed high potential in overcoming multidrug resistance in vitro with low drug resistance index.

Bai J, Wang RH, Qiao Y, Wang A, Fang CJ.

Drug Des Devel Ther. 2017 Jul 31;11:2227-2237. doi: 10.2147/DDDT.S138371. eCollection 2017.

13.

Reversal of P-gp mediated multidrug resistance in-vitro and in-vivo by FG020318.

Chen LM, Liang YJ, Ruan JW, Ding Y, Wang XW, Shi Z, Gu LQ, Yang XP, Fu LW.

J Pharm Pharmacol. 2004 Aug;56(8):1061-6.

PMID:
15285852
14.
15.

Synthesis and biological evaluation of a novel artesunate-podophyllotoxin conjugate as anticancer agent.

Zhang L, Chen F, Zhang Z, Chen Y, Wang J.

Bioorg Med Chem Lett. 2016 Jan 1;26(1):38-42. doi: 10.1016/j.bmcl.2015.11.042. Epub 2015 Nov 14.

PMID:
26615886
16.

Arminin 1a-C, a novel antimicrobial peptide from ancient metazoan Hydra, shows potent antileukemia activity against drug-sensitive and drug-resistant leukemia cells.

Liang X, Wang R, Dou W, Zhao L, Zhou L, Zhu J, Wang K, Yan J.

Drug Des Devel Ther. 2018 Oct 31;12:3691-3703. doi: 10.2147/DDDT.S181188. eCollection 2018.

17.

Design, synthesis, and discovery of ocotillol-type amide derivatives as orally available modulators of P-glycoprotein-mediated multidrug resistance.

Ren Q, Yang G, Guo M, Guo J, Li Y, Lu J, Yang Q, Tang H, Li Y, Fang X, Sun Y, Qi JG, Tian J, Wang H.

Eur J Med Chem. 2019 Jan 1;161:118-130. doi: 10.1016/j.ejmech.2018.10.038. Epub 2018 Oct 16.

PMID:
30347326
18.

pH sensitive liposomes delivering tariquidar and doxorubicin to overcome multidrug resistance of resistant ovarian cancer cells.

Xia Y, Fang M, Dong J, Xu C, Liao Z, Ning P, Zeng Q.

Colloids Surf B Biointerfaces. 2018 Oct 1;170:514-520. doi: 10.1016/j.colsurfb.2018.06.055. Epub 2018 Jun 27.

PMID:
29960952
19.

Design, Synthesis, and Preclinical Evaluation of 4-Substituted-5-methyl-furo[2,3-d]pyrimidines as Microtubule Targeting Agents That Are Effective against Multidrug Resistant Cancer Cells.

Devambatla RK, Namjoshi OA, Choudhary S, Hamel E, Shaffer CV, Rohena CC, Mooberry SL, Gangjee A.

J Med Chem. 2016 Jun 23;59(12):5752-65. doi: 10.1021/acs.jmedchem.6b00237. Epub 2016 Jun 7.

20.

Nitrogen-containing ecdysteroid derivatives vs. multi-drug resistance in cancer: Preparation and antitumor activity of oximes, oxime ethers and a lactam.

Vágvölgyi M, Martins A, Kulmány Á, Zupkó I, Gáti T, Simon A, Tóth G, Hunyadi A.

Eur J Med Chem. 2018 Jan 20;144:730-739. doi: 10.1016/j.ejmech.2017.12.032. Epub 2017 Dec 12.

PMID:
29291440

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