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Items: 1 to 20 of 95

1.

Using In Vitro and In-cell SHAPE to Investigate Small Molecule Induced Pre-mRNA Structural Changes.

Wang J, Hammond J, Johnson KA.

J Vis Exp. 2019 Jan 30;(143). doi: 10.3791/59021.

PMID:
30774126
2.

5-(N-ethyl-N-isopropyl)-amiloride enhances SMN2 exon 7 inclusion and protein expression in spinal muscular atrophy cells.

Yuo CY, Lin HH, Chang YS, Yang WK, Chang JG.

Ann Neurol. 2008 Jan;63(1):26-34.

PMID:
17924536
3.

Mechanistic studies of a small-molecule modulator of SMN2 splicing.

Wang J, Schultz PG, Johnson KA.

Proc Natl Acad Sci U S A. 2018 May 15;115(20):E4604-E4612. doi: 10.1073/pnas.1800260115. Epub 2018 Apr 30.

4.

hnRNP M facilitates exon 7 inclusion of SMN2 pre-mRNA in spinal muscular atrophy by targeting an enhancer on exon 7.

Cho S, Moon H, Loh TJ, Oh HK, Cho S, Choy HE, Song WK, Chun JS, Zheng X, Shen H.

Biochim Biophys Acta. 2014;1839(4):306-15. doi: 10.1016/j.bbagrm.2014.02.006. Epub 2014 Feb 15.

PMID:
24533984
5.

Restoration of SMN function: delivery of a trans-splicing RNA re-directs SMN2 pre-mRNA splicing.

Coady TH, Shababi M, Tullis GE, Lorson CL.

Mol Ther. 2007 Aug;15(8):1471-8. Epub 2007 Jun 5.

6.

Correction of SMN2 Pre-mRNA splicing by antisense U7 small nuclear RNAs.

Madocsai C, Lim SR, Geib T, Lam BJ, Hertel KJ.

Mol Ther. 2005 Dec;12(6):1013-22. Epub 2005 Oct 14.

7.
8.

Optimization of SMN trans-splicing through the analysis of SMN introns.

Shababi M, Lorson CL.

J Mol Neurosci. 2012 Mar;46(3):459-69. doi: 10.1007/s12031-011-9614-3. Epub 2011 Aug 9.

PMID:
21826391
9.

Securinine enhances SMN2 exon 7 inclusion in spinal muscular atrophy cells.

Chen YC, Chang JG, Liu TY, Jong YJ, Cheng WL, Yuo CY.

Biomed Pharmacother. 2017 Apr;88:708-714. doi: 10.1016/j.biopha.2017.01.104. Epub 2017 Jan 30.

PMID:
28152480
10.

[The expression of SMN2 gene mRNA in neuron-like cells derived from patients with spinal muscular atrophy].

Luo XM, Yang XS, Xiao B.

Zhonghua Nei Ke Za Zhi. 2006 Oct;45(10):831-4. Chinese.

PMID:
17217749
11.

Mapping RNA Structure In Vitro with SHAPE Chemistry and Next-Generation Sequencing (SHAPE-Seq).

Watters KE, Lucks JB.

Methods Mol Biol. 2016;1490:135-62. doi: 10.1007/978-1-4939-6433-8_9.

PMID:
27665597
12.

A negatively acting bifunctional RNA increases survival motor neuron both in vitro and in vivo.

Dickson A, Osman E, Lorson CL.

Hum Gene Ther. 2008 Nov;19(11):1307-15. doi: 10.1089/hgt.2008.067.

13.

Htra2-beta 1 stimulates an exonic splicing enhancer and can restore full-length SMN expression to survival motor neuron 2 (SMN2).

Hofmann Y, Lorson CL, Stamm S, Androphy EJ, Wirth B.

Proc Natl Acad Sci U S A. 2000 Aug 15;97(17):9618-23.

14.

Delivery of bifunctional RNAs that target an intronic repressor and increase SMN levels in an animal model of spinal muscular atrophy.

Baughan TD, Dickson A, Osman EY, Lorson CL.

Hum Mol Genet. 2009 May 1;18(9):1600-11. doi: 10.1093/hmg/ddp076. Epub 2009 Feb 19.

15.

Improvement of SMN2 pre-mRNA processing mediated by exon-specific U1 small nuclear RNA.

Dal Mas A, Rogalska ME, Bussani E, Pagani F.

Am J Hum Genet. 2015 Jan 8;96(1):93-103. doi: 10.1016/j.ajhg.2014.12.009. Epub 2014 Dec 31.

16.

Characterizing RNA structures in vitro and in vivo with selective 2'-hydroxyl acylation analyzed by primer extension sequencing (SHAPE-Seq).

Watters KE, Yu AM, Strobel EJ, Settle AH, Lucks JB.

Methods. 2016 Jul 1;103:34-48. doi: 10.1016/j.ymeth.2016.04.002. Epub 2016 Apr 12.

17.

PSF contacts exon 7 of SMN2 pre-mRNA to promote exon 7 inclusion.

Cho S, Moon H, Loh TJ, Oh HK, Williams DR, Liao DJ, Zhou J, Green MR, Zheng X, Shen H.

Biochim Biophys Acta. 2014 Jun;1839(6):517-25. doi: 10.1016/j.bbagrm.2014.03.003. Epub 2014 Mar 14.

18.

Targeting SR proteins improves SMN expression in spinal muscular atrophy cells.

Wee CD, Havens MA, Jodelka FM, Hastings ML.

PLoS One. 2014 Dec 15;9(12):e115205. doi: 10.1371/journal.pone.0115205. eCollection 2014.

19.

Genetic conversion of an SMN2 gene to SMN1: a novel approach to the treatment of spinal muscular atrophy.

DiMatteo D, Callahan S, Kmiec EB.

Exp Cell Res. 2008 Feb 15;314(4):878-86. Epub 2007 Oct 24.

PMID:
18078930
20.

Spinal muscular atrophy phenotype is ameliorated in human motor neurons by SMN increase via different novel RNA therapeutic approaches.

Nizzardo M, Simone C, Dametti S, Salani S, Ulzi G, Pagliarani S, Rizzo F, Frattini E, Pagani F, Bresolin N, Comi G, Corti S.

Sci Rep. 2015 Jun 30;5:11746. doi: 10.1038/srep11746.

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