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Identification of a Molecular Latch that Regulates Staphylococcal Virulence.

Xie Q, Zhao A, Jeffrey PD, Kim MK, Bassler BL, Stone HA, Novick RP, Muir TW.

Cell Chem Biol. 2019 Apr 18;26(4):548-558.e4. doi: 10.1016/j.chembiol.2019.01.006. Epub 2019 Feb 14.


Functional Plasticity of the AgrC Receptor Histidine Kinase Required for Staphylococcal Virulence.

Wang B, Zhao A, Xie Q, Olinares PD, Chait BT, Novick RP, Muir TW.

Cell Chem Biol. 2017 Jan 19;24(1):76-86. doi: 10.1016/j.chembiol.2016.12.008. Epub 2017 Jan 5.


Simplified Autoinducing Peptide Mimetics with Single-Nanomolar Activity Against the Staphylococcus aureus AgrC Quorum Sensing Receptor.

Vasquez JK, Blackwell HE.

ACS Infect Dis. 2019 Apr 12;5(4):484-492. doi: 10.1021/acsinfecdis.9b00002. Epub 2019 Mar 13.


Cross-Talk between Staphylococcus aureus and Other Staphylococcal Species via the agr Quorum Sensing System.

Canovas J, Baldry M, Bojer MS, Andersen PS, Grzeskowiak PK, Stegger M, Damborg P, Olsen CA, Ingmer H.

Front Microbiol. 2016 Nov 8;7:1733. eCollection 2016. Erratum in: Front Microbiol. 2017 Jun 08;8:1075. Front Microbiol. 2017 Oct 05;8:1949.


Identification of ligand specificity determinants in AgrC, the Staphylococcus aureus quorum-sensing receptor.

Geisinger E, George EA, Chen J, Muir TW, Novick RP.

J Biol Chem. 2008 Apr 4;283(14):8930-8. doi: 10.1074/jbc.M710227200. Epub 2008 Jan 25. Erratum in: J Biol Chem. 2012 May 25;287(22):18588. Chen, John [added].


Differential recognition of Staphylococcus aureus quorum-sensing signals depends on both extracellular loops 1 and 2 of the transmembrane sensor AgrC.

Jensen RO, Winzer K, Clarke SR, Chan WC, Williams P.

J Mol Biol. 2008 Aug 29;381(2):300-9. doi: 10.1016/j.jmb.2008.06.018. Epub 2008 Jun 13.


Influence of the AgrC-AgrA complex on the response time of Staphylococcus aureus quorum sensing.

Srivastava SK, Rajasree K, Fasim A, Arakere G, Gopal B.

J Bacteriol. 2014 Aug;196(15):2876-88. doi: 10.1128/JB.01530-14. Epub 2014 May 23.


Symmetric signalling within asymmetric dimers of the Staphylococcus aureus receptor histidine kinase AgrC.

George Cisar EA, Geisinger E, Muir TW, Novick RP.

Mol Microbiol. 2009 Oct;74(1):44-57. doi: 10.1111/j.1365-2958.2009.06849.x. Epub 2009 Aug 24.


Structure-Function Analyses of a Staphylococcus epidermidis Autoinducing Peptide Reveals Motifs Critical for AgrC-type Receptor Modulation.

Yang T, Tal-Gan Y, Paharik AE, Horswill AR, Blackwell HE.

ACS Chem Biol. 2016 Jul 15;11(7):1982-91. doi: 10.1021/acschembio.6b00120. Epub 2016 May 18.


Control of Staphylococcus aureus Quorum Sensing by a Membrane-Embedded Peptidase.

Cosgriff CJ, White CR, Teoh WP, Grayczyk JP, Alonzo F 3rd.

Infect Immun. 2019 Apr 23;87(5). pii: e00019-19. doi: 10.1128/IAI.00019-19. Print 2019 Mar.


Structural characterization of native autoinducing peptides and abiotic analogues reveals key features essential for activation and inhibition of an AgrC quorum sensing receptor in Staphylococcus aureus.

Tal-Gan Y, Ivancic M, Cornilescu G, Cornilescu CC, Blackwell HE.

J Am Chem Soc. 2013 Dec 11;135(49):18436-44. doi: 10.1021/ja407533e. Epub 2013 Nov 25.


Increasing AIP Macrocycle Size Reveals Key Features of agr Activation in Staphylococcus aureus.

Johnson JG, Wang B, Debelouchina GT, Novick RP, Muir TW.

Chembiochem. 2015 May 4;16(7):1093-100. doi: 10.1002/cbic.201500006. Epub 2015 Mar 20.


agr receptor mutants reveal distinct modes of inhibition by staphylococcal autoinducing peptides.

Geisinger E, Muir TW, Novick RP.

Proc Natl Acad Sci U S A. 2009 Jan 27;106(4):1216-21. doi: 10.1073/pnas.0807760106. Epub 2009 Jan 15.


Activation and inhibition of the receptor histidine kinase AgrC occurs through opposite helical transduction motions.

Wang B, Zhao A, Novick RP, Muir TW.

Mol Cell. 2014 Mar 20;53(6):929-40. doi: 10.1016/j.molcel.2014.02.029.


Cyclic peptide inhibitors of staphylococcal virulence prepared by Fmoc-based thiolactone peptide synthesis.

George EA, Novick RP, Muir TW.

J Am Chem Soc. 2008 Apr 9;130(14):4914-24. doi: 10.1021/ja711126e. Epub 2008 Mar 12.


Simplified AIP-II Peptidomimetics Are Potent Inhibitors of Staphylococcus aureus AgrC Quorum Sensing Receptors.

Vasquez JK, Tal-Gan Y, Cornilescu G, Tyler KA, Blackwell HE.

Chembiochem. 2017 Feb 16;18(4):413-423. doi: 10.1002/cbic.201600516. Epub 2017 Jan 20.


Highly potent inhibitors of quorum sensing in Staphylococcus aureus revealed through a systematic synthetic study of the group-III autoinducing peptide.

Tal-Gan Y, Stacy DM, Foegen MK, Koenig DW, Blackwell HE.

J Am Chem Soc. 2013 May 29;135(21):7869-82. doi: 10.1021/ja3112115. Epub 2013 May 17.


Ligand-receptor recognition for activation of quorum sensing in Staphylococcus aureus.

Chen LC, Tsou LT, Chen FJ.

J Microbiol. 2009 Oct;47(5):572-81. doi: 10.1007/s12275-009-0004-2. Epub 2009 Oct 24.


Structure, activity and evolution of the group I thiolactone peptide quorum-sensing system of Staphylococcus aureus.

MDowell P, Affas Z, Reynolds C, Holden MT, Wood SJ, Saint S, Cockayne A, Hill PJ, Dodd CE, Bycroft BW, Chan WC, Williams P.

Mol Microbiol. 2001 Jul;41(2):503-12.

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