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Targeting intermittent hypoxia downstream pathways for biomarker discovery and new treatment perspectives in cutaneous melanoma.

Minovès M, Pépin JL, Godin-Ribuot D.

Eur Respir J. 2019 Jan 31;53(2). pii: 1802444. doi: 10.1183/13993003.02444-2018. Print 2019 Feb. No abstract available.


Antiangiogenic agents targeting different angiogenic pathways have opposite effects on tumor hypoxia in R-18 human melanoma xenografts.

Gaustad JV, Simonsen TG, Andersen LMK, Rofstad EK.

BMC Cancer. 2017 Jun 12;17(1):411. doi: 10.1186/s12885-017-3404-4.


Intermittent Hypoxia Is Associated With High Hypoxia Inducible Factor-1α but Not High Vascular Endothelial Growth Factor Cell Expression in Tumors of Cutaneous Melanoma Patients.

Almendros I, Martínez-García MÁ, Campos-Rodríguez F, Riveiro-Falkenbach E, Rodríguez-Peralto JL, Nagore E, Martorell-Calatayud A, Hernández Blasco L, Bañuls Roca J, Chiner Vives E, Sánchez-de-la-Torre A, Abad-Capa J, Montserrat JM, Pérez-Gil A, Cabriada-Nuño V, Cano-Pumarega I, Corral-Peñafiel J, Diaz-Cambriles T, Mediano O, Dalmau-Arias J, Farré R, Gozal D; Spanish Sleep Network.

Front Neurol. 2018 Apr 26;9:272. doi: 10.3389/fneur.2018.00272. eCollection 2018.


Intermittent hypoxia increases melanoma metastasis to the lung in a mouse model of sleep apnea.

Almendros I, Montserrat JM, Torres M, Dalmases M, Cabañas ML, Campos-Rodríguez F, Navajas D, Farré R.

Respir Physiol Neurobiol. 2013 May 1;186(3):303-7. doi: 10.1016/j.resp.2013.03.001. Epub 2013 Mar 14.


Endothelin-1 and endothelin-3 promote invasive behavior via hypoxia-inducible factor-1alpha in human melanoma cells.

Spinella F, Rosanò L, Di Castro V, Decandia S, Nicotra MR, Natali PG, Bagnato A.

Cancer Res. 2007 Feb 15;67(4):1725-34.


Network analysis of temporal effects of intermittent and sustained hypoxia on rat lungs.

Wu W, Dave NB, Yu G, Strollo PJ, Kovkarova-Naumovski E, Ryter SW, Reeves SR, Dayyat E, Wang Y, Choi AM, Gozal D, Kaminski N.

Physiol Genomics. 2008 Dec 12;36(1):24-34. doi: 10.1152/physiolgenomics.00258.2007. Epub 2008 Sep 30.


Metastatic pathways in patients with cutaneous melanoma.

Adler NR, Haydon A, McLean CA, Kelly JW, Mar VJ.

Pigment Cell Melanoma Res. 2017 Jan;30(1):13-27. doi: 10.1111/pcmr.12544. Epub 2016 Nov 30. Review.


Hippocampal mitogen-activated protein kinase activation is associated with intermittent hypoxia in a rat model of obstructive sleep apnea syndrome.

Zhao YN, Wang HY, Li JM, Chen BY, Xia G, Zhang PP, Ge YL.

Mol Med Rep. 2016 Jan;13(1):137-45. doi: 10.3892/mmr.2015.4505. Epub 2015 Nov 5.


Obstructive sleep apnea and dyslipidemia: implications for atherosclerosis.

Drager LF, Jun J, Polotsky VY.

Curr Opin Endocrinol Diabetes Obes. 2010 Apr;17(2):161-5. doi: 10.1097/MED.0b013e3283373624. Review. Erratum in: Curr Opin Endocrinol Diabetes Obes. 2010 Aug;17(4):394.


Metabonomic profiling of chronic intermittent hypoxia in a mouse model.

Conotte S, Tassin A, Conotte R, Colet JM, Zouaoui Boudjeltia K, Legrand A.

Respir Physiol Neurobiol. 2018 Oct;256:157-173. doi: 10.1016/j.resp.2018.02.015. Epub 2018 Mar 6.


[Effect of intermittent hypoxia on lipid metabolism in liver cells and the underlying mechanism].

Sun Z, Shen W.

Zhonghua Gan Zang Bing Za Zhi. 2014 May;22(5):369-73. doi: 10.3760/cma.j.issn.1007-3418.2014.05.010. Chinese.


The potential for BRAF V600 inhibitors in advanced cutaneous melanoma: rationale and latest evidence.

Lemech C, Infante J, Arkenau HT.

Ther Adv Med Oncol. 2012 Mar;4(2):61-73. doi: 10.1177/1758834011432949.


The discovery of vemurafenib for the treatment of BRAF-mutated metastatic melanoma.

Kim A, Cohen MS.

Expert Opin Drug Discov. 2016 Sep;11(9):907-16. doi: 10.1080/17460441.2016.1201057. Epub 2016 Jun 23. Review.


Targeting mutant NRAS signaling pathways in melanoma.

Vu HL, Aplin AE.

Pharmacol Res. 2016 May;107:111-116. doi: 10.1016/j.phrs.2016.03.007. Epub 2016 Mar 15. Review.


Intermittent hypoxia promotes melanoma lung metastasis via oxidative stress and inflammation responses in a mouse model of obstructive sleep apnea.

Li L, Ren F, Qi C, Xu L, Fang Y, Liang M, Feng J, Chen B, Ning W, Cao J.

Respir Res. 2018 Feb 12;19(1):28. doi: 10.1186/s12931-018-0727-x.


Proteases in cutaneous malignant melanoma: relevance as biomarker and therapeutic target.

Fröhlich E.

Cell Mol Life Sci. 2010 Dec;67(23):3947-60. doi: 10.1007/s00018-010-0469-5. Epub 2010 Aug 5. Review.


Inhibition of Siah2 ubiquitin ligase by vitamin K3 (menadione) attenuates hypoxia and MAPK signaling and blocks melanoma tumorigenesis.

Shah M, Stebbins JL, Dewing A, Qi J, Pellecchia M, Ronai ZA.

Pigment Cell Melanoma Res. 2009 Dec;22(6):799-808. doi: 10.1111/j.1755-148X.2009.00628.x. Epub 2009 Aug 27.


Models of intermittent hypoxia and obstructive sleep apnea: molecular pathways and their contribution to cancer.

Hunyor I, Cook KM.

Am J Physiol Regul Integr Comp Physiol. 2018 Oct 1;315(4):R669-R687. doi: 10.1152/ajpregu.00036.2018. Epub 2018 Jul 11.


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