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Items: 1 to 20 of 115


Macrophage achieves self-protection against oxidative stress-induced ageing through the Mst-Nrf2 axis.

Wang P, Geng J, Gao J, Zhao H, Li J, Shi Y, Yang B, Xiao C, Linghu Y, Sun X, Chen X, Hong L, Qin F, Li X, Yu JS, You H, Yuan Z, Zhou D, Johnson RL, Chen L.

Nat Commun. 2019 Feb 14;10(1):755. doi: 10.1038/s41467-019-08680-6.


Nrf2 deficiency induces oxidative stress and promotes RANKL-induced osteoclast differentiation.

Hyeon S, Lee H, Yang Y, Jeong W.

Free Radic Biol Med. 2013 Dec;65:789-799. doi: 10.1016/j.freeradbiomed.2013.08.005. Epub 2013 Aug 14.


NFE2-Related Transcription Factor 2 Coordinates Antioxidant Defense with Thyroglobulin Production and Iodination in the Thyroid Gland.

Ziros PG, Habeos IG, Chartoumpekis DV, Ntalampyra E, Somm E, Renaud CO, Bongiovanni M, Trougakos IP, Yamamoto M, Kensler TW, Santisteban P, Carrasco N, Ris-Stalpers C, Amendola E, Liao XH, Rossich L, Thomasz L, Juvenal GJ, Refetoff S, Sykiotis GP.

Thyroid. 2018 Jun;28(6):780-798. doi: 10.1089/thy.2018.0018.


TAK1 Regulates the Nrf2 Antioxidant System Through Modulating p62/SQSTM1.

Hashimoto K, Simmons AN, Kajino-Sakamoto R, Tsuji Y, Ninomiya-Tsuji J.

Antioxid Redox Signal. 2016 Dec 10;25(17):953-964. Epub 2016 Jun 30.


The Keap1/Nrf2 protein axis plays a role in osteoclast differentiation by regulating intracellular reactive oxygen species signaling.

Kanzaki H, Shinohara F, Kajiya M, Kodama T.

J Biol Chem. 2013 Aug 9;288(32):23009-20. doi: 10.1074/jbc.M113.478545. Epub 2013 Jun 25. Erratum in: J Biol Chem. 2014 Feb 28;289(9):5536.


MicroRNA-140-5p attenuated oxidative stress in Cisplatin induced acute kidney injury by activating Nrf2/ARE pathway through a Keap1-independent mechanism.

Liao W, Fu Z, Zou Y, Wen D, Ma H, Zhou F, Chen Y, Zhang M, Zhang W.

Exp Cell Res. 2017 Nov 15;360(2):292-302. doi: 10.1016/j.yexcr.2017.09.019. Epub 2017 Sep 18. Erratum in: Exp Cell Res. 2017 Dec 1;361(1):199.


Daphnetin-mediated Nrf2 antioxidant signaling pathways ameliorate tert-butyl hydroperoxide (t-BHP)-induced mitochondrial dysfunction and cell death.

Lv H, Liu Q, Zhou J, Tan G, Deng X, Ci X.

Free Radic Biol Med. 2017 May;106:38-52. doi: 10.1016/j.freeradbiomed.2017.02.016. Epub 2017 Feb 7.


Activation of Nrf2 in defense against cadmium-induced oxidative stress.

He X, Chen MG, Ma Q.

Chem Res Toxicol. 2008 Jul;21(7):1375-83. doi: 10.1021/tx800019a. Epub 2008 May 31.


Protective roles of NRF2 signaling pathway in cobalt chloride-induced hypoxic cytotoxicity in human HaCaT keratinocytes.

Yang B, Cheng H, Wang L, Fu J, Zhang G, Guan D, Qi R, Gao X, Zhao R.

Toxicol Appl Pharmacol. 2018 Sep 15;355:189-197. doi: 10.1016/j.taap.2018.06.030. Epub 2018 Jun 30.


SERPINA3K protects against oxidative stress via modulating ROS generation/degradation and KEAP1-NRF2 pathway in the corneal epithelium.

Zhou T, Zong R, Zhang Z, Zhu C, Pan F, Xiao X, Liu Z, He H, Ma JX, Liu Z, Zhou Y.

Invest Ophthalmol Vis Sci. 2012 Jul 27;53(8):5033-43. doi: 10.1167/iovs.12-9729.


Kinases Mst1 and Mst2 positively regulate phagocytic induction of reactive oxygen species and bactericidal activity.

Geng J, Sun X, Wang P, Zhang S, Wang X, Wu H, Hong L, Xie C, Li X, Zhao H, Liu Q, Jiang M, Chen Q, Zhang J, Li Y, Song S, Wang HR, Zhou R, Johnson RL, Chien KY, Lin SC, Han J, Avruch J, Chen L, Zhou D.

Nat Immunol. 2015 Nov;16(11):1142-52. doi: 10.1038/ni.3268. Epub 2015 Sep 28.


Signaling pathways activated by the phytochemical nordihydroguaiaretic acid contribute to a Keap1-independent regulation of Nrf2 stability: Role of glycogen synthase kinase-3.

Rojo AI, Medina-Campos ON, Rada P, Zúñiga-Toalá A, López-Gazcón A, Espada S, Pedraza-Chaverri J, Cuadrado A.

Free Radic Biol Med. 2012 Jan 15;52(2):473-87. doi: 10.1016/j.freeradbiomed.2011.11.003. Epub 2011 Nov 12.


Expression of xCT and activity of system xc(-) are regulated by NRF2 in human breast cancer cells in response to oxidative stress.

Habib E, Linher-Melville K, Lin HX, Singh G.

Redox Biol. 2015 Aug;5:33-42. doi: 10.1016/j.redox.2015.03.003. Epub 2015 Mar 18.


Targeting the KEAP1-NRF2 System to Prevent Kidney Disease Progression.

Nezu M, Suzuki N, Yamamoto M.

Am J Nephrol. 2017;45(6):473-483. doi: 10.1159/000475890. Epub 2017 May 13. Review.


miRNA-141 attenuates UV-induced oxidative stress via activating Keap1-Nrf2 signaling in human retinal pigment epithelium cells and retinal ganglion cells.

Cheng LB, Li KR, Yi N, Li XM, Wang F, Xue B, Pan YS, Yao J, Jiang Q, Wu ZF.

Oncotarget. 2017 Feb 21;8(8):13186-13194. doi: 10.18632/oncotarget.14489.


MDA-7/IL-24 inhibits Nrf2-mediated antioxidant response through activation of p38 pathway and inhibition of ERK pathway involved in cancer cell apoptosis.

Tian H, Zhang D, Gao Z, Li H, Zhang B, Zhang Q, Li L, Cheng Q, Pei D, Zheng J.

Cancer Gene Ther. 2014 Oct;21(10):416-26. doi: 10.1038/cgt.2014.45. Epub 2014 Sep 19.


Asiatic acid enhances Nrf2 signaling to protect HepG2 cells from oxidative damage through Akt and ERK activation.

Qi Z, Ci X, Huang J, Liu Q, Yu Q, Zhou J, Deng X.

Biomed Pharmacother. 2017 Apr;88:252-259. doi: 10.1016/j.biopha.2017.01.067. Epub 2017 Jan 19.


Acetyl-l-carnitine prevents homocysteine-induced suppression of Nrf2/Keap1 mediated antioxidation in human lens epithelial cells.

Yang SP, Yang XZ, Cao GP.

Mol Med Rep. 2015 Jul;12(1):1145-50. doi: 10.3892/mmr.2015.3490. Epub 2015 Mar 13.


Nuclear factor erythroid-derived factor 2-related factor 2 regulates transcription of CCAAT/enhancer-binding protein β during adipogenesis.

Hou Y, Xue P, Bai Y, Liu D, Woods CG, Yarborough K, Fu J, Zhang Q, Sun G, Collins S, Chan JY, Yamamoto M, Andersen ME, Pi J.

Free Radic Biol Med. 2012 Jan 15;52(2):462-72. doi: 10.1016/j.freeradbiomed.2011.10.453. Epub 2011 Oct 28.


Epigallocatechin gallate upregulates NRF2 to prevent diabetic nephropathy via disabling KEAP1.

Sun W, Liu X, Zhang H, Song Y, Li T, Liu X, Liu Y, Guo L, Wang F, Yang T, Guo W, Wu J, Jin H, Wu H.

Free Radic Biol Med. 2017 Jul;108:840-857. doi: 10.1016/j.freeradbiomed.2017.04.365. Epub 2017 Apr 27.


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