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Induction of GNMT by 1,2,3,4,6-penta-O-galloyl-beta-D-glucopyranoside through proteasome-independent MYC downregulation in hepatocellular carcinoma.

Kant R, Yen CH, Hung JH, Lu CK, Tung CY, Chang PC, Chen YH, Tyan YC, Chen YA.

Sci Rep. 2019 Feb 13;9(1):1968. doi: 10.1038/s41598-018-37292-1.


1,2,3,4,6-Penta-O-Galloyl-Beta-D-Glucopyranoside Inhibits Proliferation of Multiple Myeloma Cells Accompanied with Suppression of MYC Expression.

Tseeleesuren D, Kant R, Yen CH, Hsiao HH, Chen YA.

Front Pharmacol. 2018 Feb 2;9:65. doi: 10.3389/fphar.2018.00065. eCollection 2018.


MicroRNA-224 down-regulates Glycine N-methyltransferase gene expression in Hepatocellular Carcinoma.

Hung JH, Li CH, Yeh CH, Huang PC, Fang CC, Chen YF, Lee KJ, Chou CH, Cheng HY, Huang HD, Chen M, Tsai TF, Lin AM, Yen CH, Tsou AP, Tyan YC, Chen YA.

Sci Rep. 2018 Aug 16;8(1):12284. doi: 10.1038/s41598-018-30682-5.


Characterization of a glycine N-methyltransferase gene knockout mouse model for hepatocellular carcinoma: Implications of the gender disparity in liver cancer susceptibility.

Liao YJ, Liu SP, Lee CM, Yen CH, Chuang PC, Chen CY, Tsai TF, Huang SF, Lee YH, Chen YM.

Int J Cancer. 2009 Feb 15;124(4):816-26. doi: 10.1002/ijc.23979.


Functional characterization of glycine N-methyltransferase and its interactive protein DEPDC6/DEPTOR in hepatocellular carcinoma.

Yen CH, Lu YC, Li CH, Lee CM, Chen CY, Cheng MY, Huang SF, Chen KF, Cheng AL, Liao LY, Lee YH, Chen YM.

Mol Med. 2012 Mar 30;18:286-96. doi: 10.2119/molmed.2011.00331. Erratum in: Mol Med. 2012;18(1):546.


Characterization of the GNMT-HectH9-PREX2 tripartite relationship in the pathogenesis of hepatocellular carcinoma.

Li CH, Yen CH, Chen YF, Lee KJ, Fang CC, Zhang X, Lai CC, Huang SF, Lin HK, Arthur Chen YM.

Int J Cancer. 2017 May 15;140(10):2284-2297. doi: 10.1002/ijc.30652.


Penta-O-galloyl-beta-D-glucose suppresses tumor growth via inhibition of angiogenesis and stimulation of apoptosis: roles of cyclooxygenase-2 and mitogen-activated protein kinase pathways.

Huh JE, Lee EO, Kim MS, Kang KS, Kim CH, Cha BC, Surh YJ, Kim SH.

Carcinogenesis. 2005 Aug;26(8):1436-45. Epub 2005 Apr 21.


Penta-1,2,3,4,6-O-galloyl-beta-D-glucose induces p53 and inhibits STAT3 in prostate cancer cells in vitro and suppresses prostate xenograft tumor growth in vivo.

Hu H, Lee HJ, Jiang C, Zhang J, Wang L, Zhao Y, Xiang Q, Lee EO, Kim SH, Lü J.

Mol Cancer Ther. 2008 Sep;7(9):2681-91. doi: 10.1158/1535-7163.MCT-08-0456. Erratum in: Mol Cancer Ther. 2008 Nov;7(11):3654.


Involvement of autophagy induction in penta-1,2,3,4,6-O-galloyl-β-D-glucose-induced senescence-like growth arrest in human cancer cells.

Dong Y, Yin S, Jiang C, Luo X, Guo X, Zhao C, Fan L, Meng Y, Lu J, Song X, Zhang X, Chen N, Hu H.

Autophagy. 2014 Feb;10(2):296-310. doi: 10.4161/auto.27210. Epub 2013 Dec 18.


IGF2 Is Up-regulated by Epigenetic Mechanisms in Hepatocellular Carcinomas and Is an Actionable Oncogene Product in Experimental Models.

Martinez-Quetglas I, Pinyol R, Dauch D, Torrecilla S, Tovar V, Moeini A, Alsinet C, Portela A, Rodriguez-Carunchio L, Solé M, Lujambio A, Villanueva A, Thung S, Esteller M, Zender L, Llovet JM.

Gastroenterology. 2016 Dec;151(6):1192-1205. doi: 10.1053/j.gastro.2016.09.001. Epub 2016 Sep 7.


Penta-O-galloyl-beta-D-glucose induces S- and G(1)-cell cycle arrests in prostate cancer cells targeting DNA replication and cyclin D1.

Hu H, Zhang J, Lee HJ, Kim SH, Lü J.

Carcinogenesis. 2009 May;30(5):818-23. doi: 10.1093/carcin/bgp059. Epub 2009 Mar 6.


Hepatoma cells from mice deficient in glycine N-methyltransferase have increased RAS signaling and activation of liver kinase B1.

Martínez-López N, García-Rodríguez JL, Varela-Rey M, Gutiérrez V, Fernández-Ramos D, Beraza N, Aransay AM, Schlangen K, Lozano JJ, Aspichueta P, Luka Z, Wagner C, Evert M, Calvisi DF, Lu SC, Mato JM, Martínez-Chantar ML.

Gastroenterology. 2012 Sep;143(3):787-798.e13. doi: 10.1053/j.gastro.2012.05.050. Epub 2012 Jun 8.


Loss of the glycine N-methyltransferase gene leads to steatosis and hepatocellular carcinoma in mice.

Martínez-Chantar ML, Vázquez-Chantada M, Ariz U, Martínez N, Varela M, Luka Z, Capdevila A, Rodríguez J, Aransay AM, Matthiesen R, Yang H, Calvisi DF, Esteller M, Fraga M, Lu SC, Wagner C, Mato JM.

Hepatology. 2008 Apr;47(4):1191-9. doi: 10.1002/hep.22159.


Reactive oxygen species-mediated activation of JNK and down-regulation of DAXX are critically involved in penta-O-galloyl-beta-d-glucose-induced apoptosis in chronic myeloid leukemia K562 cells.

Kwon TR, Jeong SJ, Lee HJ, Lee HJ, Sohn EJ, Jung JH, Kim JH, Jung DB, Lu J, Kim SH.

Biochem Biophys Res Commun. 2012 Aug 3;424(3):530-7. doi: 10.1016/j.bbrc.2012.06.150. Epub 2012 Jul 6.


Oral administration of penta-O-galloyl-β-D-glucose suppresses triple-negative breast cancer xenograft growth and metastasis in strong association with JAK1-STAT3 inhibition.

Lee HJ, Seo NJ, Jeong SJ, Park Y, Jung DB, Koh W, Lee HJ, Lee EO, Ahn KS, Ahn KS, Lü J, Kim SH.

Carcinogenesis. 2011 Jun;32(6):804-11. doi: 10.1093/carcin/bgr015. Epub 2011 Feb 2.


Glycine N-methyltransferase deficiency affects Niemann-Pick type C2 protein stability and regulates hepatic cholesterol homeostasis.

Liao YJ, Chen TL, Lee TS, Wang HA, Wang CK, Liao LY, Liu RS, Huang SF, Chen YM.

Mol Med. 2012 May 9;18:412-22. doi: 10.2119/molmed.2011.00258.


Genotypic and phenotypic characterization of a putative tumor susceptibility gene, GNMT, in liver cancer.

Tseng TL, Shih YP, Huang YC, Wang CK, Chen PH, Chang JG, Yeh KT, Chen YM, Buetow KH.

Cancer Res. 2003 Feb 1;63(3):647-54.


A DNA methylation signature associated with the epigenetic repression of glycine N-methyltransferase in human hepatocellular carcinoma.

Huidobro C, Toraño EG, Fernández AF, Urdinguio RG, Rodríguez RM, Ferrero C, Martínez-Camblor P, Boix L, Bruix J, García-Rodríguez JL, Varela-Rey M, Mato JM, Martínez-Chantar ML, Fraga MF.

J Mol Med (Berl). 2013 Aug;91(8):939-50. doi: 10.1007/s00109-013-1010-8. Epub 2013 Mar 12.


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