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Items: 1 to 20 of 89

1.

Blimp1 Prevents Methylation of Foxp3 and Loss of Regulatory T Cell Identity at Sites of Inflammation.

Garg G, Muschaweckh A, Moreno H, Vasanthakumar A, Floess S, Lepennetier G, Oellinger R, Zhan Y, Regen T, Hiltensperger M, Peter C, Aly L, Knier B, Palam LR, Kapur R, Kaplan MH, Waisman A, Rad R, Schotta G, Huehn J, Kallies A, Korn T.

Cell Rep. 2019 Feb 12;26(7):1854-1868.e5. doi: 10.1016/j.celrep.2019.01.070.

2.

Control of the inheritance of regulatory T cell identity by a cis element in the Foxp3 locus.

Feng Y, Arvey A, Chinen T, van der Veeken J, Gasteiger G, Rudensky AY.

Cell. 2014 Aug 14;158(4):749-763. doi: 10.1016/j.cell.2014.07.031.

3.

Lkb1 maintains Treg cell lineage identity.

Wu D, Luo Y, Guo W, Niu Q, Xue T, Yang F, Sun X, Chen S, Liu Y, Liu J, Sun Z, Zhao C, Huang H, Liao F, Han Z, Zhou D, Yang Y, Xu G, Cheng T, Feng X.

Nat Commun. 2017 Jun 16;8:15876. doi: 10.1038/ncomms15876.

4.

Self-antigen-driven activation induces instability of regulatory T cells during an inflammatory autoimmune response.

Bailey-Bucktrout SL, Martinez-Llordella M, Zhou X, Anthony B, Rosenthal W, Luche H, Fehling HJ, Bluestone JA.

Immunity. 2013 Nov 14;39(5):949-62. doi: 10.1016/j.immuni.2013.10.016.

5.

TGF-β-mediated Foxp3 gene expression is cooperatively regulated by Stat5, Creb, and AP-1 through CNS2.

Ogawa C, Tone Y, Tsuda M, Peter C, Waldmann H, Tone M.

J Immunol. 2014 Jan 1;192(1):475-83. doi: 10.4049/jimmunol.1301892. Epub 2013 Dec 2.

6.

Critical Role of TGF-β and IL-2 Receptor Signaling in Foxp3 Induction by an Inhibitor of DNA Methylation.

Freudenberg K, Lindner N, Dohnke S, Garbe AI, Schallenberg S, Kretschmer K.

Front Immunol. 2018 Feb 2;9:125. doi: 10.3389/fimmu.2018.00125. eCollection 2018.

7.

Treg-specific IL-27Rα deletion uncovers a key role for IL-27 in Treg function to control autoimmunity.

Do J, Kim D, Kim S, Valentin-Torres A, Dvorina N, Jang E, Nagarajavel V, DeSilva TM, Li X, Ting AH, Vignali DAA, Stohlman SA, Baldwin WM 3rd, Min B.

Proc Natl Acad Sci U S A. 2017 Sep 19;114(38):10190-10195. doi: 10.1073/pnas.1703100114. Epub 2017 Sep 5.

8.

Foxp3⁺ Treg cells in the inflamed CNS are insensitive to IL-6-driven IL-17 production.

O'Connor RA, Floess S, Huehn J, Jones SA, Anderton SM.

Eur J Immunol. 2012 May;42(5):1174-9. doi: 10.1002/eji.201142216.

9.

Inhibition of the JAK/STAT Signaling Pathway in Regulatory T Cells Reveals a Very Dynamic Regulation of Foxp3 Expression.

Goldstein JD, Burlion A, Zaragoza B, Sendeyo K, Polansky JK, Huehn J, Piaggio E, Salomon BL, Marodon G.

PLoS One. 2016 Apr 14;11(4):e0153682. doi: 10.1371/journal.pone.0153682. eCollection 2016. Erratum in: PLoS One. 2016;11(6):e0157629.

10.

Loss of TET proteins in regulatory T cells promotes abnormal proliferation, Foxp3 destabilization and IL-17 expression.

Nakatsukasa H, Oda M, Yin J, Chikuma S, Ito M, Koga-Iizuka M, Someya K, Kitagawa Y, Ohkura N, Sakaguchi S, Koya I, Sanosaka T, Kohyama J, Tsukada YI, Yamanaka S, Takamura-Enya T, Lu Q, Yoshimura A.

Int Immunol. 2019 Apr 26;31(5):335-347. doi: 10.1093/intimm/dxz008.

PMID:
30726915
11.

Single and combined effect of retinoic acid and rapamycin modulate the generation, activity and homing potential of induced human regulatory T cells.

Candia E, Reyes P, Covian C, Rodriguez F, Wainstein N, Morales J, Mosso C, Rosemblatt M, Fierro JA.

PLoS One. 2017 Jul 26;12(7):e0182009. doi: 10.1371/journal.pone.0182009. eCollection 2017.

12.

Strong TCR stimulation promotes the stabilization of Foxp3 expression in regulatory T cells induced in vitro through increasing the demethylation of Foxp3 CNS2.

Wakamatsu E, Omori H, Kawano A, Ogawa S, Abe R.

Biochem Biophys Res Commun. 2018 Sep 18;503(4):2597-2602. doi: 10.1016/j.bbrc.2018.07.021. Epub 2018 Jul 13.

PMID:
30007439
13.

MeCP2 enforces Foxp3 expression to promote regulatory T cells' resilience to inflammation.

Li C, Jiang S, Liu SQ, Lykken E, Zhao LT, Sevilla J, Zhu B, Li QJ.

Proc Natl Acad Sci U S A. 2014 Jul 8;111(27):E2807-16. doi: 10.1073/pnas.1401505111. Epub 2014 Jun 23.

14.

The transcriptional repressor Bcl6 controls the stability of regulatory T cells by intrinsic and extrinsic pathways.

Sawant DV, Wu H, Yao W, Sehra S, Kaplan MH, Dent AL.

Immunology. 2015 May;145(1):11-23. doi: 10.1111/imm.12393.

15.

DNA Demethylation of the Foxp3 Enhancer Is Maintained through Modulation of Ten-Eleven-Translocation and DNA Methyltransferases.

Nair VS, Song MH, Ko M, Oh KI.

Mol Cells. 2016 Dec;39(12):888-897. doi: 10.14348/molcells.2016.0276. Epub 2016 Dec 13.

16.

Foxp1 is critical for the maintenance of regulatory T-cell homeostasis and suppressive function.

Ren J, Han L, Tang J, Liu Y, Deng X, Liu Q, Hao P, Feng X, Li B, Hu H, Wang H.

PLoS Biol. 2019 May 24;17(5):e3000270. doi: 10.1371/journal.pbio.3000270. eCollection 2019 May.

17.

Role of conserved non-coding DNA elements in the Foxp3 gene in regulatory T-cell fate.

Zheng Y, Josefowicz S, Chaudhry A, Peng XP, Forbush K, Rudensky AY.

Nature. 2010 Feb 11;463(7282):808-12. doi: 10.1038/nature08750. Epub 2010 Jan 13.

18.

HIV infection of human regulatory T cells downregulates Foxp3 expression by increasing DNMT3b levels and DNA methylation in the FOXP3 gene.

Pion M, Jaramillo-Ruiz D, Martínez A, Muñoz-Fernández MA, Correa-Rocha R.

AIDS. 2013 Aug 24;27(13):2019-29. doi: 10.1097/QAD.0b013e32836253fd.

PMID:
24201117
19.

Hypomethylation at the regulatory T cell-specific demethylated region in CD25hi T cells is decoupled from FOXP3 expression at the inflamed site in childhood arthritis.

Bending D, Pesenacker AM, Ursu S, Wu Q, Lom H, Thirugnanabalan B, Wedderburn LR.

J Immunol. 2014 Sep 15;193(6):2699-708. doi: 10.4049/jimmunol.1400599. Epub 2014 Aug 4.

20.

Histone methylation mediates plasticity of human FOXP3(+) regulatory T cells by modulating signature gene expressions.

He H, Ni B, Tian Y, Tian Z, Chen Y, Liu Z, Yang X, Lv Y, Zhang Y.

Immunology. 2014 Mar;141(3):362-76. doi: 10.1111/imm.12198.

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