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Items: 1 to 20 of 104

1.

Structural Basis for Recognition of Ubiquitylated Nucleosome by Dot1L Methyltransferase.

Anderson CJ, Baird MR, Hsu A, Barbour EH, Koyama Y, Borgnia MJ, McGinty RK.

Cell Rep. 2019 Feb 12;26(7):1681-1690.e5. doi: 10.1016/j.celrep.2019.01.058.

2.

Structural Basis of Dot1L Stimulation by Histone H2B Lysine 120 Ubiquitination.

Valencia-Sánchez MI, De Ioannes P, Wang M, Vasilyev N, Chen R, Nudler E, Armache JP, Armache KJ.

Mol Cell. 2019 Jun 6;74(5):1010-1019.e6. doi: 10.1016/j.molcel.2019.03.029. Epub 2019 Apr 10.

PMID:
30981630
3.

Structural basis of recognition and destabilization of the histone H2B ubiquitinated nucleosome by the DOT1L histone H3 Lys79 methyltransferase.

Jang S, Kang C, Yang HS, Jung T, Hebert H, Chung KY, Kim SJ, Hohng S, Song JJ.

Genes Dev. 2019 Jun 1;33(11-12):620-625. doi: 10.1101/gad.323790.118. Epub 2019 Mar 28.

PMID:
30923167
4.

Mechanism of Cross-talk between H2B Ubiquitination and H3 Methylation by Dot1L.

Worden EJ, Hoffmann NA, Hicks CW, Wolberger C.

Cell. 2019 Mar 7;176(6):1490-1501.e12. doi: 10.1016/j.cell.2019.02.002. Epub 2019 Feb 11.

PMID:
30765112
5.

The upstreams and downstreams of H3K79 methylation by DOT1L.

Vlaming H, van Leeuwen F.

Chromosoma. 2016 Sep;125(4):593-605. doi: 10.1007/s00412-015-0570-5. Epub 2016 Jan 4. Review.

PMID:
26728620
6.

Structure-activity analysis of semisynthetic nucleosomes: mechanistic insights into the stimulation of Dot1L by ubiquitylated histone H2B.

McGinty RK, Köhn M, Chatterjee C, Chiang KP, Pratt MR, Muir TW.

ACS Chem Biol. 2009 Nov 20;4(11):958-68. doi: 10.1021/cb9002255.

7.

Methylation of Histone H3K79 by Dot1L Requires Multiple Contacts with the Ubiquitinated Nucleosome.

Zhang Y, Kutateladze TG.

Mol Cell. 2019 Jun 6;74(5):862-863. doi: 10.1016/j.molcel.2019.05.013.

PMID:
31173720
8.

Activation and regulation of H2B-Ubiquitin-dependent histone methyltransferases.

Worden EJ, Wolberger C.

Curr Opin Struct Biol. 2019 Jun 20;59:98-106. doi: 10.1016/j.sbi.2019.05.009. [Epub ahead of print] Review.

PMID:
31229920
9.

Chemical Synthesis of K34-Ubiquitylated H2B for Nucleosome Reconstitution and Single-Particle Cryo-Electron Microscopy Structural Analysis.

Li J, He Q, Liu Y, Liu S, Tang S, Li C, Sun D, Li X, Zhou M, Zhu P, Bi G, Zhou Z, Zheng JS, Tian C.

Chembiochem. 2017 Jan 17;18(2):176-180. doi: 10.1002/cbic.201600551. Epub 2016 Dec 15.

PMID:
27976477
10.

DOT1L/KMT4 recruitment and H3K79 methylation are ubiquitously coupled with gene transcription in mammalian cells.

Steger DJ, Lefterova MI, Ying L, Stonestrom AJ, Schupp M, Zhuo D, Vakoc AL, Kim JE, Chen J, Lazar MA, Blobel GA, Vakoc CR.

Mol Cell Biol. 2008 Apr;28(8):2825-39. doi: 10.1128/MCB.02076-07. Epub 2008 Feb 19.

11.

The histone methyltransferase DOT1L: regulatory functions and a cancer therapy target.

Wong M, Polly P, Liu T.

Am J Cancer Res. 2015 Aug 15;5(9):2823-37. eCollection 2015.

12.

Histone H2B ubiquitin ligase RNF20 is required for MLL-rearranged leukemia.

Wang E, Kawaoka S, Yu M, Shi J, Ni T, Yang W, Zhu J, Roeder RG, Vakoc CR.

Proc Natl Acad Sci U S A. 2013 Mar 5;110(10):3901-6. doi: 10.1073/pnas.1301045110. Epub 2013 Feb 14.

13.

The histone methyltransferase Dot1/DOT1L as a critical regulator of the cell cycle.

Kim W, Choi M, Kim JE.

Cell Cycle. 2014;13(5):726-38. doi: 10.4161/cc.28104. Epub 2014 Feb 6. Review.

14.

Deficiency of H3K79 histone methyltransferase Dot1-like protein (DOT1L) inhibits cell proliferation.

Kim W, Kim R, Park G, Park JW, Kim JE.

J Biol Chem. 2012 Feb 17;287(8):5588-99. doi: 10.1074/jbc.M111.328138. Epub 2011 Dec 21.

15.

Dot1L mediated histone H3 lysine79 methylation is essential to meiosis progression in mouse oocytes.

Wang X, Gao W, Ma X, Wang X, Song C, Huang X, Liu H.

Neuro Endocrinol Lett. 2014;35(6):523-30.

PMID:
25433842
16.

Regulation of Wnt signaling target gene expression by the histone methyltransferase DOT1L.

Gibbons GS, Owens SR, Fearon ER, Nikolovska-Coleska Z.

ACS Chem Biol. 2015 Jan 16;10(1):109-14. doi: 10.1021/cb500668u. Epub 2014 Nov 10.

PMID:
25361163
17.

The histone H3K79 methyltransferase Dot1L is essential for mammalian development and heterochromatin structure.

Jones B, Su H, Bhat A, Lei H, Bajko J, Hevi S, Baltus GA, Kadam S, Zhai H, Valdez R, Gonzalo S, Zhang Y, Li E, Chen T.

PLoS Genet. 2008 Sep 12;4(9):e1000190. doi: 10.1371/journal.pgen.1000190.

18.

Conserved crosstalk between histone deacetylation and H3K79 methylation generates DOT1L-dose dependency in HDAC1-deficient thymic lymphoma.

Vlaming H, McLean CM, Korthout T, Alemdehy MF, Hendriks S, Lancini C, Palit S, Klarenbeek S, Kwesi-Maliepaard EM, Molenaar TM, Hoekman L, Schmidlin TT, Altelaar AM, van Welsem T, Dannenberg JH, Jacobs H, van Leeuwen F.

EMBO J. 2019 Jun 17. pii: e101564. doi: 10.15252/embj.2019101564. [Epub ahead of print]

19.

A medicinal chemistry perspective for targeting histone H3 lysine-79 methyltransferase DOT1L.

Anglin JL, Song Y.

J Med Chem. 2013 Nov 27;56(22):8972-83. doi: 10.1021/jm4007752. Epub 2013 Aug 14. Review.

20.

Histone H2BK120 Ubiquitination Stabilizes DOT1L on Nucleosomes.

[No authors listed]

Cancer Discov. 2019 Jun;9(6):OF9. doi: 10.1158/2159-8290.CD-RW2019-060. Epub 2019 Apr 19.

PMID:
31003976

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