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Analysis of ubiquitin recognition by the HECT ligase E6AP provides insight into its linkage specificity.

Ries LK, Sander B, Deol KK, Letzelter MA, Strieter ER, Lorenz S.

J Biol Chem. 2019 Apr 12;294(15):6113-6129. doi: 10.1074/jbc.RA118.007014. Epub 2019 Feb 8.


Oligomerization of the HECT ubiquitin ligase NEDD4-2/NEDD4L is essential for polyubiquitin chain assembly.

Todaro DR, Augustus-Wallace AC, Klein JM, Haas AL.

J Biol Chem. 2018 Nov 23;293(47):18192-18206. doi: 10.1074/jbc.RA118.003716. Epub 2018 Oct 4.


Ubiquitin chain specificities of E6AP E3 ligase and its HECT domain.

Kobayashi F, Nishiuchi T, Takaki K, Konno H.

Biochem Biophys Res Commun. 2018 Feb 5;496(2):686-692. doi: 10.1016/j.bbrc.2017.12.076. Epub 2017 Dec 27.


In silico modeling of the cryptic E2∼ubiquitin-binding site of E6-associated protein (E6AP)/UBE3A reveals the mechanism of polyubiquitin chain assembly.

Ronchi VP, Kim ED, Summa CM, Klein JM, Haas AL.

J Biol Chem. 2017 Nov 3;292(44):18006-18023. doi: 10.1074/jbc.M117.813477. Epub 2017 Sep 18.


The active form of E6-associated protein (E6AP)/UBE3A ubiquitin ligase is an oligomer.

Ronchi VP, Klein JM, Edwards DJ, Haas AL.

J Biol Chem. 2014 Jan 10;289(2):1033-48. doi: 10.1074/jbc.M113.517805. Epub 2013 Nov 22.


Structure of the HHARI catalytic domain shows glimpses of a HECT E3 ligase.

Spratt DE, Mercier P, Shaw GS.

PLoS One. 2013 Aug 15;8(8):e74047. doi: 10.1371/journal.pone.0074047. eCollection 2013.


β-Sheet Augmentation Is a Conserved Mechanism of Priming HECT E3 Ligases for Ubiquitin Ligation.

Jäckl M, Stollmaier C, Strohäker T, Hyz K, Maspero E, Polo S, Wiesner S.

J Mol Biol. 2018 Sep 14;430(18 Pt B):3218-3233. doi: 10.1016/j.jmb.2018.06.044. Epub 2018 Jun 28.


Mechanism of ubiquitin chain synthesis employed by a HECT domain ubiquitin ligase.

French ME, Klosowiak JL, Aslanian A, Reed SI, Yates JR 3rd, Hunter T.

J Biol Chem. 2017 Jun 23;292(25):10398-10413. doi: 10.1074/jbc.M117.789479. Epub 2017 May 1.


The mechanism of neural precursor cell expressed developmentally down-regulated 4-2 (Nedd4-2)/NEDD4L-catalyzed polyubiquitin chain assembly.

Todaro DR, Augustus-Wallace AC, Klein JM, Haas AL.

J Biol Chem. 2017 Nov 24;292(47):19521-19536. doi: 10.1074/jbc.M117.817882. Epub 2017 Sep 28.


Structure of an E6AP-UbcH7 complex: insights into ubiquitination by the E2-E3 enzyme cascade.

Huang L, Kinnucan E, Wang G, Beaudenon S, Howley PM, Huibregtse JM, Pavletich NP.

Science. 1999 Nov 12;286(5443):1321-6.


Role of ubiquitin and the HPV E6 oncoprotein in E6AP-mediated ubiquitination.

Mortensen F, Schneider D, Barbic T, Sladewska-Marquardt A, Kühnle S, Marx A, Scheffner M.

Proc Natl Acad Sci U S A. 2015 Aug 11;112(32):9872-7. doi: 10.1073/pnas.1505923112. Epub 2015 Jul 27.


E6AP/UBE3A ubiquitin ligase harbors two E2~ubiquitin binding sites.

Ronchi VP, Klein JM, Haas AL.

J Biol Chem. 2013 Apr 12;288(15):10349-60. doi: 10.1074/jbc.M113.458059. Epub 2013 Feb 25.


The -4 phenylalanine is required for substrate ubiquitination catalyzed by HECT ubiquitin ligases.

Salvat C, Wang G, Dastur A, Lyon N, Huibregtse JM.

J Biol Chem. 2004 Apr 30;279(18):18935-43. Epub 2004 Feb 13.


Regulating the human HECT E3 ligases.

Sluimer J, Distel B.

Cell Mol Life Sci. 2018 Sep;75(17):3121-3141. doi: 10.1007/s00018-018-2848-2. Epub 2018 Jun 1. Review.


Activity-based E3 ligase profiling uncovers an E3 ligase with esterification activity.

Pao KC, Wood NT, Knebel A, Rafie K, Stanley M, Mabbitt PD, Sundaramoorthy R, Hofmann K, van Aalten DMF, Virdee S.

Nature. 2018 Apr;556(7701):381-385. doi: 10.1038/s41586-018-0026-1. Epub 2018 Apr 11.


Human ubiquitin-protein ligase Nedd4: expression, subcellular localization and selective interaction with ubiquitin-conjugating enzymes.

Anan T, Nagata Y, Koga H, Honda Y, Yabuki N, Miyamoto C, Kuwano A, Matsuda I, Endo F, Saya H, Nakao M.

Genes Cells. 1998 Nov;3(11):751-63.


Regulation of the RSP5 ubiquitin ligase by an intrinsic ubiquitin-binding site.

French ME, Kretzmann BR, Hicke L.

J Biol Chem. 2009 May 1;284(18):12071-9. doi: 10.1074/jbc.M901106200. Epub 2009 Feb 27.


1H, 13C, and 15N resonance assignments of the C-terminal lobe of the human HECT E3 ubiquitin ligase ITCH.

Beasley SA, Bardhi R, Spratt DE.

Biomol NMR Assign. 2019 Apr;13(1):15-20. doi: 10.1007/s12104-018-9843-2. Epub 2018 Sep 18.


Certain pairs of ubiquitin-conjugating enzymes (E2s) and ubiquitin-protein ligases (E3s) synthesize nondegradable forked ubiquitin chains containing all possible isopeptide linkages.

Kim HT, Kim KP, Lledias F, Kisselev AF, Scaglione KM, Skowyra D, Gygi SP, Goldberg AL.

J Biol Chem. 2007 Jun 15;282(24):17375-86. Epub 2007 Apr 10.

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